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How to get fromSantander to Sicilyby plane, car, car ferry, bus or train (Renfe, Trenitalia)

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There are 10 ways to get from Santander to Sicily by plane, car, car ferry, bus, or train (Renfe, Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Santander Airport to Palermo Airport

    best
    1. Fly from Santander Airport (SDR) to Palermo Airport (PMO)planeSDR - PMO
    8h 45m
    €66–289
  2. Drive, car ferry

    1. Drive from Santander to Port of Genoacar
    2. Take the car ferry from Port of Genoa to Port of Palermocarferry
    33h 6m
    €266–430
  3. Bus via Bordeaux

    1. Take the bus from Santander to Bordeauxbus
    2. Take the bus from Bordeaux to Florence Villa Constanza Bus Stationbus
    3. Take the bus from Florence Villa Constanza Bus Station to Palermobus
    43h 9m
    €122–304
  4. Train

    1. Take the train from Santander to Madrid ChamartíntrainAlv / ...
    2. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charlestrain
    3. Take the train from Marseille St Charles to Roma Terminitrain
    4. Take the train from Roma Termini to Palermo CentraletrainIc
    43h 58m
    €291–606
  5. Bus to Bilbao Airport, fly to Palermo Airport

    1. Take the bus from Santander E.A. to Bilbao Intermodalbus
    2. Fly from Bilbao Airport (BIO) to Palermo Airport (PMO)planeBIO - PMO
    7h 33m
    €82–250
  6. Bus to Bilbao Airport, fly to Catania–Fontanarossa Airport

    1. Take the bus from Santander E.A. to Bilbao Intermodalbus
    2. Fly from Bilbao Airport (BIO) to Catania–Fontanarossa Airport (CTA)planeBIO - CTA
    9h 10m
    €75–268
  7. Fly Santander Airport to Catania–Fontanarossa Airport

    1. Fly from Santander Airport (SDR) to Catania–Fontanarossa Airport (CTA)planeSDR - CTA
    7h 27m
    €134–557
  8. Bus, bus to Vitoria-Gasteiz Airport, fly to Palermo Airport

    1. Take the bus from Santander E.A. to Bilbao Intermodalbus
    2. Take the bus from Bilbao Bolueta to Aireportua/Aeropuerto Vitoria-Gasteizbus
    3. Fly from Vitoria-Gasteiz Airport (VIT) to Palermo Airport (PMO)planeVIT - PMO
    15h 13m
    €98–315
  9. Bus, car ferry

    1. Take the bus from Santander E.A. to Bilbao Intermodalbus
    2. Take the bus from Bilbao to Nice Airportbus
    3. Take the bus from Nice Airport to Genoabus798 / ...
    4. Take the car ferry from Port of Genoa to Port of Palermocarferry
    45h 49m
    €145–334
  10. Bus

    1. Take the bus from Santander E.A. to Vitoria-Gasteizbus
    2. Take the bus from Vitoria Gasteiz Central Bus Station to Milano, Autostazione Lampugnanobus
    3. Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus
    2d 2h
    €126–192

Santander to Sicily by bus

Calendar5Weekly Buses
Duration43h 9mAverage Duration
Ticket€122Cheapest Price
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Questions & Answers

What companies run services between Santander, Spain and Sicily, Italy?

Vueling Airlines, Iberia, and Ryanair fly from Santander Airport (SDR) to Palermo Airport (PMO) 6 times a week. Alternatively, you can take a bus from Santander to Piazza Boiardo via Bordeaux, Florence Villa Constanza Bus Station, Palermo, and Stazione Centrale Pensilina Esterna in around 43h 9m.

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