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How to get fromSantander to Sicilyby plane, car, car ferry, bus or train (Renfe, Trenitalia)

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There are 6 ways to get from Santander to Sicily by plane, car, car ferry, bus, or train (Renfe, Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Santander Airport (SDR) to Palermo Airport (PMO)planeSDR - PMO
    6h 30m
    €60–246

  2. Drive, car ferry

    1. Drive from Santander to Port of Genoacar
    2. Take the car ferry from Port of Genoa to Port of Palermocarferry
    33h 6m
    €261–430

  3. Bus

    1. Take the bus from Santander to Bordeauxbus
    2. Take the bus from Bordeaux to Florence Villa Constanza Bus Stationbus
    3. Take the bus from Florence Villa Constanza Bus Station to Palermobus
    43h 8m
    €121–302

  4. Train

    1. Take the train from Santander to Madrid ChamartíntrainAlv / ...
    2. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charlestrain
    3. Take the train from Marseille St Charles to Roma Terminitrain
    4. Take the train from Roma Termini to Palermo CentraletrainIc
    43h 57m
    €298–596

  5. Bus via Milan

    1. Take the bus from Santander E.A. to Estación de Autobuses Donostia-San Sebastiánbus
    2. Take the bus from San Sebastian Central Bus Station to Milano, Autostazione Lampugnanobus
    3. Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus
    44h 16m
    €114–190

  6. Bus, car ferry

    1. Take the bus from Santander E.A. to Bilbao Intermodalbus
    2. Take the bus from Bilbao to Nice Airportbus
    3. Take the bus from Nice Airport to Genoabus798 / ...
    4. Take the car ferry from Port of Genoa to Port of Palermocarferry
    45h 49m
    €130–316

Santander to Sicily by bus

Calendar5Weekly Buses
Duration43h 8mAverage Duration
Ticket€121Cheapest Price
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Questions & Answers

What companies run services between Santander, Spain and Sicily, Italy?

Vueling Airlines, Iberia, and Ryanair fly from Santander Airport (SDR) to Palermo Airport (PMO) once daily. Alternatively, you can take a bus from Santander to Piazza Boiardo via Bordeaux, Florence Villa Constanza Bus Station, Palermo, and Stazione Centrale Pensilina Esterna in around 43h 8m.

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