There are 6 ways to get from Santander to Palermo by plane, car, car ferry, bus, train (Renfe, Trenitalia), or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Santander Airport (SDR) to Palermo Airport (PMO)SDR - PMO
6h 30m€60–246Drive, car ferry
- Drive from Santander to Port of Genoa
- Take the car ferry from Port of Genoa to Port of Palermo
32h 59m€260–429Bus
- Take the bus from Santander to Bordeaux
- Take the bus from Bordeaux to Florence Villa Constanza Bus Station
- Take the bus from Florence Villa Constanza Bus Station to Palermo
42h 35m€119–300Train
- Take the train from Santander to Madrid ChamartínAlv / ...
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charles
- Take the train from Marseille St Charles to Roma Termini
- Take the train from Roma Termini to Palermo CentraleIc
43h 22m€296–592Bus, ferry
- Take the bus from Santander E.A. to Barcelona, Estación de Autobuses de Sants
- Take the ferry from Port de Barcelona to Port of Civitavecchia
- Take the ferry from Port of Civitavecchia to Port of Palermo
43h 5m€155–295Bus via Milan
- Take the bus from Santander E.A. to Bilbao Intermodal
- Take the bus from Bilbao Intermodal to San Sebastián / Donostia
- Take the bus from San Sebastian Central Bus Station to Milano, Autostazione Lampugnano
- Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
44h 21m€117–183
Santander to Palermo by bus
Questions & Answers
The cheapest way to get from Santander to Palermo is to bus via Milan which costs €110 - €190 and takes 44h 21m.
The fastest way to get from Santander to Palermo is to fly which takes 6h 30m and costs €60 - €250.
No, there is no direct bus from Santander to Palermo. However, there are services departing from Santander and arriving at Palermo via Bordeaux and Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 42h 35m.
No, there is no direct train from Santander to Palermo. However, there are services departing from Santander and arriving at Palermo Centrale via Madrid Chamartín, Madrid-Puerta de Atocha-Almudena Grandes, Marseille St Charles and Roma Termini. The journey, including transfers, takes approximately 43h 22m.
The distance between Santander and Palermo is 1567 km.
The best way to get from Santander to Palermo without a car is to bus which takes 42h 35m and costs €110 - €300.
It takes approximately 6h 30m to get from Santander to Palermo, including transfers.
Santander to Palermo bus services, operated by FlixBus, depart from Santander station.
Santander to Palermo train services, operated by Renfe Viajeros, depart from Santander station.
The best way to get from Santander to Palermo is to fly which takes 6h 30m and costs €60 - €250. Alternatively, you can bus, which costs €110 - €300 and takes 42h 35m, you could also train, which costs €290 - €600 and takes 43h 22m.
What companies run services between Santander, Spain and Palermo, Italy?
Vueling Airlines, Iberia, and Ryanair fly from Santander Airport (SDR) to Palermo Airport (PMO) once daily. Alternatively, you can take a bus from Santander to Palermo via Bordeaux and Florence Villa Constanza Bus Station in around 42h 35m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- ryanair.com
Flights from Santander Airport to Palermo Airport via London Stansted
- Ave. Duration
- 10h 20m
- When
- Thursday
- Estimated price
- €95–300
Flights from Santander Airport to Palermo Airport via Charleroi
- Ave. Duration
- 12h
- When
- Monday
- Estimated price
- €90–290
Flights from Santander Airport to Palermo Airport via Madrid
- Ave. Duration
- 7h 27m
- When
- Wednesday, Friday, and Saturday
- Estimated price
- €80–270
- Website
- iberia.com
Flights from Santander Airport to Palermo Airport via Barcelona
- Ave. Duration
- 5h 30m
- When
- Monday and Saturday
- Estimated price
- €55–240
Flights from Santander Airport to Palermo Airport via Madrid
- Ave. Duration
- 10h 10m
- When
- Monday and Thursday
- Estimated price
- €85–320
- Website
- vueling.com
Flights from Santander Airport to Palermo Airport via Barcelona
- Ave. Duration
- 5h 30m
- When
- Monday and Saturday
- Estimated price
- €55–240
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Santander to Madrid Chamartín
- Ave. Duration
- 4h 14m
- Frequency
- Twice daily
- Estimated price
- €30–85
- Website
- https://www.renfe.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charles
- Ave. Duration
- 8h 15m
- Frequency
- Once daily
- Estimated price
- €90–130
- Website
- https://www.renfe.com/es/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Marseille St Charles to Roma Termini
- Ave. Duration
- 16h 2m
- Frequency
- Once a week
- Estimated price
- €130–270
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 36m
- Frequency
- Once daily
- Estimated price
- €40–110
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Santander to Bordeaux
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- €24–50
- Website
- https://www.flixbus.co.uk
Bus from Bordeaux to Florence Villa Constanza Bus Station
- Ave. Duration
- 17h 15m
- Frequency
- 5 times a week
- Estimated price
- €60–130
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Palermo
- Ave. Duration
- 17h 15m
- Frequency
- Twice daily
- Estimated price
- €40–120
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Florence Villa Constanza Bus Station to Palermo
- Ave. Duration
- 16h
- Frequency
- Twice a week
- Estimated price
- €35–55
- Schedules at
- autoservizisalemi.it
Bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from Santander E.A. to Barcelona, Estación de Autobuses de Sants
- Ave. Duration
- 8h 45m
- Frequency
- 3 times a day
- Estimated price
- €50–130
- Website
- https://www.alsa.com/en/
Bus from Santander E.A. to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–15
- Website
- https://www.alsa.com/en/
Bus from Bilbao Intermodal to San Sebastián / Donostia
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- €12–17
- Website
- https://gipuzkoa.avanzagrupo.com/en/home
- Phone
- 07001 8282
- booking@union-ivkoni.com
- Website
- union-ivkoni.com
Bus from San Sebastian Central Bus Station to Milano, Autostazione Lampugnano
- Ave. Duration
- 16h 30m
- Frequency
- 3 times a week
- Estimated price
- €45–70
- Website
- https://union-ivkoni.com/en
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–140
- Website
- https://www.gnv.it/en
Ferry from Port of Civitavecchia to Port of Palermo
- Ave. Duration
- 12h
- Frequency
- Once a week
- Estimated price
- €55–70
- Website
- https://www.gnv.it/en
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port de Barcelona to Port of Civitavecchia
- Ave. Duration
- 20h
- Frequency
- 5 times a week
- Estimated price
- €45–95
- Website
- https://www.grimaldi-lines.com/en/
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More Questions & Answers
Santander to Palermo bus services, operated by FlixBus, arrive at Bordeaux station.
Santander to Palermo train services, operated by Renfe Viajeros, arrive at Madrid Chamartín station.
Book your Santander to Palermo train tickets online with Omio.
Book your Santander to Palermo bus tickets online with Omio and FlixBus.
There are 5834+ hotels available in Palermo.





































