There are 9 ways to get from Santander to Mainz by plane, bus, train, car, or train (Renfe, TGV)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Santander Airport to Frankfurt
best- Fly from Santander Airport (SDR) to Frankfurt (FRA)plane SDR - FRA
4h 34m€113–300Bus to Bilbao Airport, fly to Frankfurt
cheapest- Take the bus from Estación de autobuses de Santander to Bilbao Intermodalbus
- Fly from Bilbao Airport (BIO) to Frankfurt (FRA)plane BIO - FRA
7h 9m€93–269Bus, train
- Take the bus from Estación de autobuses de Santander to Bordeauxbus
- Take the train from Bordeaux St Jean to Strasbourgtrain Tgv
- Take the train from Strasbourg to Karlsruhe Hbftrain Ice / ...
- Take the train from Karlsruhe Hauptbahnhof to Mainz, Hauptbahnhoftrain Re4
16h 43m€266–438Bus
- Take the bus from Estación de autobuses de Santander to Parisbus FlixBus 783
- Take the bus from Paris, Quai de Bercy (Bercy Seine) to Mainz central train stationbus N90 / ...
21h 25m€134–206Drive 1,483.4 km
- Drive from Santander to Mainzcar 1,483.4 km
14h 54m€276–398Fly Santander Airport to Hahn, bus
- Fly from Santander Airport (SDR) to Hahn (HHN)plane SDR - HHN
- Take the bus from Hahn to Mainz, Hauptbahnhofbus
9h 6m€122–445Bus, train via Irun
- Take the bus from Estación de autobuses de Santander to Estación de Autobuses Donostia-San Sebastiánbus
- Take the train from Hendaye to Bordeaux St Jeantrain Ter
- Take the train from Bordeaux St Jean to Strasbourgtrain Tgv
- Take the train from Strasbourg Bahnhof to Mannheim, Hauptbahnhoftrain 82 / ...
- Take the train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhoftrain S5 / ...
18h 6m€293–483Train
- Take the train from Santander to Madrid Chamartíntrain Alv / ...
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Avignon Tgvtrain
- Take the train from Avignon Tgv to Mannheim Hbftrain Tgv
- Take the train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhoftrain S5 / ...
22h 22m€363–554Bus, train #2
- Take the bus from Estación de autobuses de Santander to Bilbao Intermodalbus
- Take the bus from Bilbao Intermodal to Luxembourgbus
- Take the bus from Luxembourg to Saarbrücken Hbfbus L40
- Take the train from Saarbrücken Hbf to Mainz, Römisches Theatertrain Re3
26h 14m
Santander to Mainz by bus, foot, and train
Comparing Your Travel Options
The cheapest way to get from Santander to Mainz is to bus and fly which costs €90 - €270 and takes 7h 9m.
The fastest way to get from Santander to Mainz is to fly which takes 4h 34m and costs €110 - €300.
No, there is no direct bus from Santander to Mainz station. However, there are services departing from Estación de autobuses de Santander and arriving at Mainz central train station via Paris, Quai de Bercy (Bercy Seine). The journey, including transfers, takes approximately 21h 25m.
No, there is no direct train from Santander to Mainz. However, there are services departing from Santander and arriving at Mainz, Hauptbahnhof via Madrid Chamartín, Madrid-Puerta de Atocha-Almudena Grandes, Avignon Tgv and Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 22h 22m.
The distance between Santander and Mainz is 1222 km. The road distance is 1483.4 km.
The best way to get from Santander to Mainz without a car is to bus and train which takes 16h 43m and costs €260 - €440.
It takes approximately 4h 34m to get from Santander to Mainz, including transfers.
Santander to Mainz bus services, operated by FlixBus, depart from Estación de autobuses de Santander station.
Santander to Mainz train services, operated by Renfe Viajeros, depart from Santander station.
The best way to get from Santander to Mainz is to fly which takes 4h 34m and costs €110 - €300. Alternatively, you can bus, which costs €130 - €210 and takes 21h 25m, you could also train, which costs €360 - €600 and takes 22h 22m.
What companies run services between Santander, Spain and Mainz, Germany?
Iberia, Ulendo Airlink, and seven other airlines fly from Santander Airport (SDR) to Frankfurt (FRA) 3 times a day. Alternatively, you can take a bus from Estación de autobuses de Santander to Mainz central train station via Paris and Paris, Quai de Bercy (Bercy Seine) in around 21h 25m.
- Website
- lufthansa.com
Flights from Santander Airport to Frankfurt via Manchester
- Ave. Duration
- 5h 32m
- When
- Tuesday and Sunday
- Estimated price
- €70–290
Flights from Santander Airport to Frankfurt via Palma Mallorca
- Ave. Duration
- 5h 5m
- When
- Friday
- Estimated price
- €95–290
Flights from Santander Airport to Frankfurt via Barcelona
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- €120–420
Flights from Bilbao Airport to Frankfurt
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- €45–270
- Website
- ryanair.com
Flights from Santander Airport to Hahn via Marrakech
- Ave. Duration
- 9h 20m
- When
- Saturday
- Estimated price
- €180–550
Flights from Santander Airport to Hahn via London Stansted
- Ave. Duration
- 11h 5m
- When
- Saturday and Monday
- Estimated price
- €100–430
Flights from Santander Airport to Hahn via Barcelona
- Ave. Duration
- 6h 55m
- When
- Monday, Thursday, Saturday, and Sunday
- Estimated price
- €110–440
- Website
- lufthansa-city.com
Flights from Santander Airport to Frankfurt via Manchester
- Ave. Duration
- 5h 32m
- When
- Tuesday and Sunday
- Estimated price
- €70–290
Flights from Bilbao Airport to Frankfurt
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- €45–260
- Website
- airfrance.com
Flights from Bilbao Airport to Frankfurt via Paris Charles de Gaulle
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- €50–270
- Website
- iberia.com
Flights from Santander Airport to Frankfurt via Madrid
- Ave. Duration
- 4h 55m
- When
- Every day
- Estimated price
- €70–370
- Website
- condor.com
Flights from Santander Airport to Frankfurt via Milan Malpensa
- Ave. Duration
- 4h
- When
- Monday and Friday
- Estimated price
- €45–260
- Website
- airbus.com
Flights from Santander Airport to Frankfurt via Palma Mallorca
- Ave. Duration
- 5h 5m
- When
- Friday
- Estimated price
- €95–290
- Website
- brusselsairlines.com
Flights from Bilbao Airport to Frankfurt via Brussels
- Ave. Duration
- 4h 40m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €55–220
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Bordeaux St Jean to Strasbourg
- Ave. Duration
- 5h 47m
- Frequency
- Once daily
- Estimated price
- €200–310
- Website
- TGV inOui
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 44 min
- Frequency
- 5 times a day
- Estimated price
- €16–24
- Website
- TGV inOui
Train from Hendaye to Bordeaux St Jean
- Ave. Duration
- 2h 34m
- Frequency
- 4 times a day
- Estimated price
- €45–70
- Website
- TGV inOui
Train from Bordeaux St Jean to Strasbourg
- Ave. Duration
- 5h 47m
- Frequency
- Once daily
- Estimated price
- €200–310
- Website
- TGV inOui
Train from Strasbourg Bahnhof to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 22m
- Frequency
- Twice daily
- Estimated price
- €28–45
- Website
- TGV inOui
Train from Avignon Tgv to Mannheim Hbf
- Ave. Duration
- 6h 27m
- Frequency
- Once daily
- Estimated price
- €170–260
- Website
- TGV inOui
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 39 min
- Frequency
- Every 4 hours
- Estimated price
- €12–26
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 2h 23m
- Frequency
- 3 times a day
- Estimated price
- €22–45
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg Bahnhof to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 4m
- Frequency
- 4 times a day
- Estimated price
- €22–50
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 51m
- Frequency
- Every 3 hours
- Estimated price
- €11–23
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 51m
- Frequency
- Every 3 hours
- Estimated price
- €11–23
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 49 min
- Frequency
- Twice a week
- Estimated price
- €15–24
- Website
- Oui.SNCF
Train from Hendaye to Bordeaux St Jean
- Ave. Duration
- 2h 39m
- Frequency
- 5 times a day
- Estimated price
- €45–70
- Website
- Oui.SNCF
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Karlsruhe Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Every 4 hours
- Estimated price
- €23–35
- Schedules at
- Süwex
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 52 min
- Frequency
- Every 4 hours
- Estimated price
- €14–20
- Schedules at
- Süwex
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 52 min
- Frequency
- Every 4 hours
- Estimated price
- €14–20
- Schedules at
- Süwex
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Karlsruhe Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 2h 25m
- Frequency
- Every 4 hours
- Estimated price
- €15–22
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 23m
- Frequency
- Hourly
- Estimated price
- €7–11
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 23m
- Frequency
- Hourly
- Estimated price
- €7–11
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Santander to Madrid Chamartín
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- €55–80
- Website
- Renfe Viajeros
Train from Madrid-Puerta de Atocha-Almudena Grandes to Avignon Tgv
- Ave. Duration
- 8h 2m
- Frequency
- Once daily
- Estimated price
- €130–190
- Website
- Renfe Viajeros
- Phone
- +49 6731 999 27-27
- info@vlexx.de
- Website
- vlexx
Train from Saarbrücken Hbf to Mainz, Römisches Theater
- Ave. Duration
- 2h 22m
- Frequency
- Hourly
- Estimated price
- €29–45
- Schedules at
- vlexx
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Estación de autobuses de Santander to Bordeaux
- Ave. Duration
- 6h
- Frequency
- 5 times a week
- Estimated price
- €35–60
- Website
- Flixbus
Bus from Estación de autobuses de Santander to Paris
- Ave. Duration
- 13h 5m
- Frequency
- 5 times a week
- Estimated price
- €85–140
- Website
- Flixbus
Bus from Paris, Quai de Bercy (Bercy Seine) to Mainz central train station
- Ave. Duration
- 7h 20m
- Frequency
- 3 times a day
- Estimated price
- €45–75
- Website
- Flixbus
- Phone
- +49 (0) 6543 5019-400
- reisebuero@bohr.de
- Website
- Bohr
Bus from Hahn to Mainz, Hauptbahnhof
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €14–16
- Schedules at
- Bohr
- Phone
- +34 910 207 007
- Website
- ALSA
Bus from Estación de autobuses de Santander to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–14
- Website
- ALSA
Bus from Estación de autobuses de Santander to Estación de Autobuses Donostia-San Sebastián
- Ave. Duration
- 2h 50m
- Frequency
- Every 4 hours
- Estimated price
- €17–27
- Website
- ALSA
Bus from Estación de autobuses de Santander to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–14
- Website
- ALSA
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Bilbao Intermodal to Luxembourg
- Ave. Duration
- 18h 30m
- Frequency
- Once daily
- Estimated price
- €100–170
- Website
- BlaBlaCar Bus
- Phone
- +352 24 89 24 89
- Website
- Luxembourg Railways (CFL)
Bus from Luxembourg to Saarbrücken Hbf
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Website
- Luxembourg Railways (CFL)
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Booking & Getting There
Santander to Mainz bus services, operated by FlixBus, arrive at Paris station.
Santander to Mainz train services, operated by Renfe Viajeros, arrive at Madrid Chamartín station.
Yes, the driving distance between Santander to Mainz is 1483 km. It takes approximately 14h 54m to drive from Santander to Mainz.
Book your Santander to Mainz train tickets online with Omio.
Book your Santander to Mainz bus tickets online with Omio, FlixBus and 12go.asia.
There are 1228+ hotels available in Mainz.











































