There are 6 ways to get from Santander to Lyon by plane, train (Renfe, Ouigo), bus, car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Santander Airport (SDR) to Lyon–Saint Exupéry Airport (LYS)plane SDR - LYS
4h 51m€105–333Bus
cheapest- Take the bus from Estación de autobuses de Santander to Bilbao Intermodalbus ALSA - Stder-Irun / ...
- Take the bus from Bilbao Intermodal to Lyon - Gerland Bus Stationbus BlaBlaCar Bus
15h€69–123Train
- Take the train from Santander to Madrid Chamartíntrain Alv / ...
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Santstrain Ave
- Take the train from Barcelona-Sants to Lyon Part Dieutrain
13h 30m€181–351Drive 954.9 km
- Drive from Santander to Lyoncar 954.9 km
9h 29m€156–225Bus, train
- Take the bus from Estación de autobuses de Santander to Bilbao Intermodalbus
- Take the bus from Bilbao to Bayonnebus
- Take the train from Bayonne to Toulouse Matabiautrain
- Take the train from Toulouse Matabiau to Lyon Part Dieutrain Tgv
14h 6m€187–298Bus via Bilbao
- Take the bus from Estación de autobuses de Santander to Bilbao Intermodalbus ALSA - Stder-Irun / ...
- Take the bus from Bilbao to Lyonbus FlixBus N1149 / ...
15h 30m€79–123
Santander to Lyon by train
Comparing Your Travel Options
The cheapest way to get from Santander to Lyon is to bus which costs €65 - €130 and takes 15h.
The fastest way to get from Santander to Lyon is to fly which takes 4h 51m and costs €100 - €340.
No, there is no direct bus from Santander to Lyon station. However, there are services departing from Estación de autobuses de Santander and arriving at Lyon - Gerland Bus Station via Bilbao Intermodal. The journey, including transfers, takes approximately 15h.
No, there is no direct train from Santander to Lyon. However, there are services departing from Santander and arriving at Lyon Part Dieu via Madrid Chamartín, Madrid-Puerta de Atocha-Almudena Grandes and Barcelona-Sants. The journey, including transfers, takes approximately 13h 30m.
The distance between Santander and Lyon is 771 km. The road distance is 954.9 km.
The best way to get from Santander to Lyon without a car is to train which takes 13h 30m and costs €180 - €360.
It takes approximately 4h 51m to get from Santander to Lyon, including transfers.
Santander to Lyon bus services, operated by ALSA, depart from Estación de autobuses de Santander station.
Santander to Lyon train services, operated by Renfe Viajeros, depart from Santander station.
The best way to get from Santander to Lyon is to fly which takes 4h 51m and costs €100 - €340. Alternatively, you can train, which costs €180 - €360 and takes 13h 30m, you could also bus, which costs €65 - €130 and takes 15h.
What companies run services between Santander, Spain and Lyon, France?
Vueling Airlines, Iberia, and two other airlines fly from Santander Airport (SDR) to Lyon–Saint Exupéry Airport (LYS) 3 times a day. Alternatively, you can take a train from Santander to Lyon Part Dieu via Madrid Chamartín, Madrid-Atocha Cercanías, Madrid-Puerta de Atocha-Almudena Grandes, and Barcelona-Sants in around 13h 30m.
- Website
- vueling.com
Flights from Santander Airport to Lyon–Saint Exupéry Airport via Barcelona
- Ave. Duration
- 5h 26m
- When
- Friday, Saturday, Tuesday, Monday, and Sunday
- Estimated price
- €80–280
Flights from Santander Airport to Lyon–Saint Exupéry Airport via Madrid
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- €85–420
- Website
- iberia.com
Flights from Santander Airport to Lyon–Saint Exupéry Airport via Barcelona
- Ave. Duration
- 5h 26m
- When
- Friday, Saturday, Tuesday, Monday, and Sunday
- Estimated price
- €80–280
Flights from Santander Airport to Lyon–Saint Exupéry Airport via Madrid
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- €85–420
- Website
- transavia.com
Flights from Santander Airport to Lyon–Saint Exupéry Airport via Sevilla
- Ave. Duration
- 6h 40m
- When
- Monday
- Estimated price
- €120–600
Rome2Rio's guide to Renfe Viajeros
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Santander to Madrid Chamartín
- Ave. Duration
- 4h
- Frequency
- Every 4 hours
- Estimated price
- €55–80
- Website
- Renfe Viajeros
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 29m
- Frequency
- 4 times a day
- Estimated price
- €75–110
- Website
- Renfe Viajeros
Train from Barcelona-Sants to Lyon Part Dieu
- Ave. Duration
- 5h 6m
- Frequency
- Twice daily
- Estimated price
- €80–120
- Website
- Renfe Viajeros
Rome2Rio's guide to Renfe AVE
Contact DetailsContact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe AVE
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 2m
- Frequency
- Every 30 minutes
- Estimated price
- €85–150
- Website
- Renfe AVE
- Phone
- +34 900 926 851
- atencion.cliente@iryo.eu
- Website
- Iryo
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 24m
- Frequency
- Hourly
- Estimated price
- €55–95
- Website
- Iryo
- Phone
- +34 900 759 781
- Website
- Ouigo
Train from Madrid-Puerta de Atocha-Almudena Grandes to Barcelona-Sants
- Ave. Duration
- 3h 27m
- Frequency
- Hourly
- Estimated price
- €45–80
- Website
- Ouigo
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Bayonne to Toulouse Matabiau
- Ave. Duration
- 3h 28m
- Frequency
- Every 4 hours
- Estimated price
- €55–95
- Website
- Oui.SNCF
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Toulouse Matabiau to Lyon Part Dieu
- Ave. Duration
- 4h 10m
- Frequency
- Every 4 hours
- Estimated price
- €110–170
- Website
- TGV inOui
- Phone
- +34 910 207 007
- Website
- ALSA
Bus from Estación de autobuses de Santander to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–14
- Website
- ALSA
Bus from Estación de autobuses de Santander to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–14
- Website
- ALSA
Bus from Estación de autobuses de Santander to Bilbao Intermodal
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–14
- Website
- ALSA
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Bilbao Intermodal to Lyon - Gerland Bus Station
- Ave. Duration
- 12h 30m
- Frequency
- Twice a week
- Estimated price
- €60–110
- Website
- BlaBlaCar Bus
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Bilbao to Bayonne
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €13–20
- Website
- Flixbus
Bus from Bilbao to Lyon
- Ave. Duration
- 13h
- Frequency
- Twice daily
- Estimated price
- €70–110
- Website
- Flixbus
Want to know more about travelling around France
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Train travel in Spain: A guide to Renfe
Read the travel guide
What are the different types of Renfe trains in Spain?
Read the travel guide
Booking & Getting There
Santander to Lyon bus services, operated by ALSA, arrive at Bilbao Intermodal station.
Santander to Lyon train services, operated by Renfe Viajeros, arrive at Madrid Chamartín station.
Yes, the driving distance between Santander to Lyon is 955 km. It takes approximately 9h 29m to drive from Santander to Lyon.
Book your Santander to Lyon train tickets online with Omio.
Book your Santander to Lyon bus tickets online with Omio.
There are 1422+ hotels available in Lyon.



































