There are 8 ways to get from Santa Rosa Beach to Key Largo by taxi, plane, shuttle, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle
best- Take the taxi from Santa Rosa Beach to Destin–Fort Walton Beach Airport (VPS)taxi
- Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane VPS - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
4h 40m$223–537Drive 634 mi
cheapest- Drive from Santa Rosa Beach to Key Largocar 634 mi
12h 12m$116–168Taxi, bus, train
- Take the taxi from Santa Rosa Beach to Whataburger - Defuniak Springstaxi
- Take the bus from Whataburger - Defuniak Springs to Circle K - Gainesville, FLbus
- Take the bus from Gainesville to Orlando RedCoach Stationbus
- Take the train from Orlando to Miamitrain
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus
15h 28m$221–601Taxi to Northwest Florida Beaches International Airport, fly to Miami International Airport, shuttle
- Take the taxi from Santa Rosa Beach to Northwest Florida Beaches International Airport (ECP)taxi
- Fly from Northwest Florida Beaches International Airport (ECP) to Miami International Airport (MIA)plane ECP - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
7h 49m$264–621Taxi to Destin–Fort Walton Beach Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Take the taxi from Santa Rosa Beach to Destin–Fort Walton Beach Airport (VPS)taxi
- Fly from Destin–Fort Walton Beach Airport (VPS) to Fort Lauderdale–Hollywood International Airport (FLL)plane VPS - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
7h 38m$248–537Taxi, bus to Tallahassee, fly to Miami International Airport, shuttle
- Take the taxi from Santa Rosa Beach to Whataburger - Defuniak Springstaxi
- Take the bus from Whataburger - Defuniak Springs to Flying J Travel Cntr - Tallahassee, FLbus
- Fly from Tallahassee (TLH) to Miami International Airport (MIA)plane TLH - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
7h 15m$306–809Taxi, bus
- Take the taxi from Santa Rosa Beach to Whataburger - Defuniak Springstaxi
- Take the bus from Whataburger - Defuniak Springs to Dolphin Mall - Miamibus
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
18h 4m$187–330Taxi, bus via Crestview
- Take the taxi from Santa Rosa Beach to Crestviewtaxi
- Take the bus from Crestview to Miamibus
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
18h 54m$226–285
Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA) flights
Questions & Answers
The cheapest way to get from Santa Rosa Beach to Key Largo is to drive which costs $110 - $170 and takes 12h 12m.
The fastest way to get from Santa Rosa Beach to Key Largo is to taxi and fly and shuttle which takes 4h 40m and costs $220 - $550.
The distance between Santa Rosa Beach and Key Largo is 591 miles. The road distance is 637.7 miles.
The best way to get from Santa Rosa Beach to Key Largo without a car is to taxi and bus and train which takes 15h 28m and costs $220 - $600.
It takes approximately 4h 40m to get from Santa Rosa Beach to Key Largo, including transfers.
Key Largo is 1h ahead of Santa Rosa Beach. It is currently 12:31 AM in Santa Rosa Beach and 1:31 AM in Key Largo.
Yes, the driving distance between Santa Rosa Beach to Key Largo is 638 miles. It takes approximately 12h 12m to drive from Santa Rosa Beach to Key Largo.
There are 314+ hotels available in Key Largo.
What companies run services between Santa Rosa Beach, FL, USA and Key Largo, FL, USA?
There is no direct connection from Santa Rosa Beach to Key Largo. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Miami International Airport (MIA), walk to Miami, FL - International Airport, then take the shuttle to Key Largo, FL. Alternatively, you can take the taxi to Whataburger - Defuniak Springs, take the bus to Circle K - Gainesville, FL, take the taxi to Gainesville, take the bus to Orlando RedCoach Station, take the taxi to Orlando, take the train to Miami, walk to Historic Overtown/Lyric Theatre Stat.Rail Northbound, take the line 2600 train to Miami Airport Station, walk to Miami, Airport Intermodal Station, then take the bus to Key Largo Bus Stop.
- Website
- delta.com
Flights from Northwest Florida Beaches International Airport to Miami International Airport via Atlanta
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $70–380
Flights from Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $55–300
- Website
- aa.com
Flights from Destin–Fort Walton Beach Airport to Miami International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $50–320
Flights from Northwest Florida Beaches International Airport to Miami International Airport via Charlotte
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $85–420
Flights from Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 6h 35m
- When
- Every day
- Estimated price
- $65–330
Flights from Tallahassee to Miami International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $60–410
- Website
- southwest.com
Flights from Northwest Florida Beaches International Airport to Miami International Airport via Nashville
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $90–450
Flights from Northwest Florida Beaches International Airport to Miami International Airport via Houston Hobby Apt
- Ave. Duration
- 5h 50m
- When
- Saturday and Sunday
- Estimated price
- $110–500
Flights from Northwest Florida Beaches International Airport to Miami International Airport via St. Louis
- Ave. Duration
- 6h 15m
- When
- Tuesday and Wednesday
- Estimated price
- $120–550
Flights from Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport via Nashville
- Ave. Duration
- 7h 10m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $70–340
- Website
- united.com
Flights from Northwest Florida Beaches International Airport to Miami International Airport via Houston
- Ave. Duration
- 7h 22m
- When
- Every day
- Estimated price
- $110–500
- Website
- allegiantair.com
Flights from Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport via Knoxville
- Ave. Duration
- 6h 47m
- When
- Thursday
- Estimated price
- $65–330
Flights from Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport via Memphis
- Ave. Duration
- 9h 8m
- When
- Friday
- Estimated price
- $70–350
- Phone
- +1 831-539-2901
- guestservices@gobrightline.com
- Website
- gobrightline.com
Train from Orlando to Miami
- Ave. Duration
- 3h 34m
- Frequency
- Every 2 hours
- Estimated price
- $15–230
- Book at
- https://www.gobrightline.com
- Smart
- $15–200
- Premium
- $65–230
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- https://www.keysshuttle.com
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Whataburger - Defuniak Springs to Circle K - Gainesville, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $60–170
- Schedules at
- tornadobus.com
- Adults 11-59
- $60–170
Bus from Whataburger - Defuniak Springs to Flying J Travel Cntr - Tallahassee, FL
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $40–140
- Schedules at
- tornadobus.com
- Adults 11-59
- $40–140
Bus from Whataburger - Defuniak Springs to Dolphin Mall - Miami
- Ave. Duration
- 13h 15m
- Frequency
- Once daily
- Estimated price
- $110–240
- Schedules at
- tornadobus.com
- Adults 11-59
- $110–240
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Gainesville to Orlando RedCoach Station
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- $30–55
- Website
- https://www.redcoachusa.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Key Largo Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- 3 times a day
- Estimated price
- $9–18
- Website
- https://www.greyhound.com/
- Phone
- +1 786-469-5675
- Website
- miamidade.gov
Bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- $3
- Website
- https://www.miamidade.gov/global/transportation/home.page
- Adult
- $3
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Crestview to Miami
- Ave. Duration
- 13h 57m
- Frequency
- Once daily
- Estimated price
- $110–150
- Schedules at
- omnibusexpress.com
- Ave. Duration
- 44 min
- Estimated price
- $70–130
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide

















