There are 6 ways to get from Santa Ana to Mexicali by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Tijuana
best- Take the bus from Santa Ana Bus Stop to San Ysidro Bus Terminalbus FlixBus 2017 / ...
- Take the bus from Tijuana to Mexicalibus
5h 31m$666–1,372Bus
cheapest- Take the bus from Santa Ana to Tijuana - Plaza El Mexicanobus Los Angeles
- Take the bus from Tijuana to Mexicalibus
7h 3m$573–1,984Train, bus
- Take the train from Santa Ana to San Diegotrain Pacific Surfliner
- Take the bus from Tijuana to Mexicalibus
6h 10m$818–1,401Drive 321.9 km
- Drive from Santa Ana to Mexicalicar 321.9 km
3h 45m$627–905Train to Los Angeles International Airport, fly to Imperial County Airport
- Take the train from Santa Ana to L.A. Union Stationtrain
- Fly from Los Angeles International Airport (LAX) to Imperial County Airport (IPL)plane LAX - IPL
4h 23m$1,892–3,218Fly John Wayne Airport Orange County to Yuma International Airport, bus
- Fly from John Wayne Airport Orange County (SNA) to Yuma International Airport (YUM)plane SNA - YUM
- Take the bus from San Luis Río Colorado to Mexicalibus
7h 23m$1,480–7,520
Santa Ana to Mexicali by bus and foot
Questions & Answers
The cheapest way to get from Santa Ana to Mexicali is to drive which costs $600 - $950 and takes 3h 45m.
The fastest way to get from Santa Ana to Mexicali is to drive which takes 3h 45m and costs $600 - $950.
No, there is no direct bus from Santa Ana to Mexicali. However, there are services departing from Santa Ana Bus Stop and arriving at Mexicali via Tijuana. The journey, including transfers, takes approximately 5h 31m.
The distance between Santa Ana and Mexicali is 347 km. The road distance is 321.9 km.
The best way to get from Santa Ana to Mexicali without a car is to bus via Tijuana which takes 5h 31m and costs $650 - $1400.
It takes approximately 5h 31m to get from Santa Ana to Mexicali, including transfers.
Santa Ana to Mexicali bus services, operated by Flixbus USA, depart from Santa Ana Bus Stop station.
Santa Ana to Mexicali bus services, operated by Flixbus USA, arrive at San Ysidro Bus Terminal station.
Yes, the driving distance between Santa Ana to Mexicali is 322 km. It takes approximately 3h 45m to drive from Santa Ana to Mexicali.
There are 89+ hotels available in Mexicali.
What companies run services between Santa Ana, CA, USA and Mexicali, Mexico?
You can take a bus from Santa Ana Bus Stop to Mexicali via San Ysidro Bus Terminal and Tijuana in around 5h 31m.
- Website
- aa.com
Flights from John Wayne Airport Orange County to Yuma International Airport via Phoenix
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $900–5,500
- Website
- iflysouthern.com
Flights from Los Angeles International Airport to Imperial County Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $1,500–2,700
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Santa Ana to San Diego
- Ave. Duration
- 2h 3m
- Frequency
- Every 2 hours
- Estimated price
- $460–550
- Website
- https://www.amtrak.com/home.html
- Phone
- (800) 371-LINK (5465)
- Website
- metrolinktrains.com
Train from Santa Ana to L.A. Union Station
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $140–200
- Website
- https://metrolinktrains.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Santa Ana Bus Stop to San Ysidro Bus Terminal
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- $350–600
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Santa Ana Bus Stop to San Ysidro Bus Terminal
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $500–800
- Website
- https://www.greyhound.com/
- Phone
- +52 664 104 7400
- servicioalcliente@geb.mx
- Website
- abc.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 5m
- Frequency
- Every 3 hours
- Estimated price
- $310–600
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 30m
- Frequency
- 5 times a day
- Estimated price
- $120–320
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
- Phone
- +1-800-231-2222
- ifsr@greyhound.com
- Website
- greyhound.com.mx
Bus from Santa Ana to Tijuana - Plaza El Mexicano
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- $370–600
- Schedules at
- greyhound.com.mx
- Phone
- +52 55 5141 4300
- contacto@odm.com.mx
- Website
- odm.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 40m
- Frequency
- Every 20 minutes
- Estimated price
- $550–750
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $360–490
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
- Phone
- +52 55 4440 3187
- servicioalcliente@geb.mx
- Website
- autobuseselite.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 17m
- Frequency
- 5 times a day
- Estimated price
- $420–650
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 6m
- Frequency
- 4 times a day
- Estimated price
- $290–440
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
- Phone
- +52 644 410 2444
- atencionaclientes@tufesa.com.mx
- Website
- tufesa.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 30m
- Frequency
- Every 4 hours
- Estimated price
- $200–430
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $200–420
- Titanium
- $230–430
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $80–310
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $80–310
- Titanium
- $95–310
- Phone
- +52 55 4440 3187
- servicioalcliente@geb.mx
- Website
- chihuahuenses.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $440–650
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $230–350
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
- Phone
- +52 664 299 0487
- servicios@acnautobuses.com
- Website
- acnautobuses.com
Bus from Tijuana to Mexicali
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $900–1,400
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
Bus from San Luis Río Colorado to Mexicali
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $900–1,400
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
- Phone
- +52 55 4440 3187
- contacto@geb.mx
- Website
- autobusesaguacaliente.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 3h 15m
- Frequency
- Once daily
- Estimated price
- $210–290
- Schedules at
- autobusesaguacaliente.mx
- Book at
- autobusesaguacaliente.mx
Want to know more about travelling around Mexico
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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