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How to get fromSanta Ana to Indianapolisby plane, bus (Greyhound), train (Amtrak), car or train

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There are 7 ways to get from Santa Ana to Indianapolis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Indianapolis (IND)plane plane SNA - IND
    6h 38m
    $169–734

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Santa Ana Bus Stop to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2d
    $159–391

  3. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train Southwest Chief
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2d 1h
    $227–444

  4. Drive 2,046.9 mi

    1. Drive from Santa Ana to Indianapoliscar car 2,046.9 mi
    32h 46m
    $374–540

  5. Train to Los Angeles International Airport, fly

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Indianapolis (IND)plane plane LAX - IND
    7h 30m
    $191–577

  6. Train to San Diego International Airport, fly

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Indianapolis (IND)plane plane SAN - IND
    8h 11m
    $229–983

  7. Train to Burbank Bob Hope Airport, fly

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Indianapolis (IND)plane plane BUR - IND
    8h 33m
    $206–673

Santa Ana to Indianapolis by bus (Greyhound)

Calendar13Weekly Buses
Duration2dAverage Duration
Ticket$159Cheapest Price
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Questions & Answers

What companies run services between Santa Ana, CA, USA and Indianapolis, IN, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Santa Ana Bus Stop to Indianapolis Union Station via Los Angeles Union Station and St Louis Bus Station in around 2d.

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