There are 7 ways to get from Santa Ana to Henderson by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from John Wayne Airport Orange County, line 217 bus
best- Fly from John Wayne Airport Orange County (SNA) to Harry Reid International Airport (LAS)plane SNA - LAS
- Take the bus from South Strip Transit Terminal to EB Lake Mead after Boulderbus
2h 42m$74–234Drive 263.9 mi
cheapest- Drive from Santa Ana to Hendersoncar 263.9 mi
4h 22m$49–70Train, bus
- Take the train from Santa Ana to San Bernardino - Downtowntrain IE-OC Line
- Take the bus from San Bernardino to Las Vegas, NVbus Los Angeles
7h 38m$61–85Train to Los Angeles International Airport, fly, line 217 bus
- Take the train from Santa Ana to L.A. Union Stationtrain
- Fly from Los Angeles International Airport (LAX) to Harry Reid International Airport (LAS)plane LAX - LAS
- Take the bus from South Strip Transit Terminal to EB Lake Mead after Boulderbus
5h 3m$66–317Bus via Los Angeles
- Take the bus from Santa Ana to Los Angeles Union Stationbus Tijuana
- Take the bus from Los Angeles Union Station to Las Vegas Downtownbus FlixBus 2030
8h 35m$51–89Bus (Flixbus)
- Take the bus from Anaheim Regional Transportation Intermodal Center to Las Vegas Stripbus FlixBus 2037
10h 22m$49–74Bus via San Bernardino
- Take the bus from Katella + Harbor to San Bernardinobus 200
- Take the bus from San Bernardino to SB Las Vegas at Fashion Show Mallbus Riverside to Las Vegas
10h 27m$60–64
Santa Ana to Henderson by train, foot, and bus
Questions & Answers
The cheapest way to get from Santa Ana to Henderson is to drive which costs $45 - $70 and takes 4h 22m.
The fastest way to get from Santa Ana to Henderson is to fly and line 217 bus which takes 2h 42m and costs $70 - $240.
No, there is no direct bus from Santa Ana to Henderson. However, there are services departing from Santa Ana and arriving at SB Boulder before Lake Mead via Los Angeles Union Station and Bonneville Transit Center Bay 14. The journey, including transfers, takes approximately 8h 35m.
The distance between Santa Ana and Henderson is 249 miles. The road distance is 265.4 miles.
The best way to get from Santa Ana to Henderson without a car is to train and bus which takes 7h 38m and costs $60 - $85.
It takes approximately 2h 42m to get from Santa Ana to Henderson, including transfers.
Santa Ana to Henderson bus services, operated by Greyhound Mexico, depart from Santa Ana station.
Santa Ana to Henderson bus services, operated by Greyhound Mexico, arrive at Los Angeles Union Station.
Yes, the driving distance between Santa Ana to Henderson is 265 miles. It takes approximately 4h 22m to drive from Santa Ana to Henderson.
There are 1282+ hotels available in Henderson.
What companies run services between Santa Ana, CA, USA and Henderson, NV, USA?
You can take a bus from Santa Ana to SB Boulder before Lake Mead via Los Angeles Union Station, Las Vegas Downtown, and Bonneville Transit Center Bay 14 in around 8h 35m.
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $30–250
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $27–200
- Website
- delta.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $30–250
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $27–200
- Website
- united.com
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $27–200
- Website
- spirit.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 9m
- When
- Every day
- Estimated price
- $35–170
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $35–280
- Website
- flyfrontier.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 17m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $30–250
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $27–200
- Website
- aa.com
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $27–200
- Website
- flybreeze.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 15m
- When
- Monday and Friday
- Estimated price
- $95–360
- Phone
- (800) 371-LINK (5465)
- Website
- metrolinktrains.com
Train from Santa Ana to San Bernardino - Downtown
- Ave. Duration
- 1h 24m
- Frequency
- 3 times a day
- Estimated price
- $9–13
- Website
- https://metrolinktrains.com
Train from Santa Ana to L.A. Union Station
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $8–12
- Website
- https://metrolinktrains.com
- Phone
- +1 702-228-7433
- Website
- rtcsnv.com
Bus from South Strip Transit Terminal to EB Lake Mead after Boulder
- Ave. Duration
- 47 min
- Frequency
- Hourly
- Estimated price
- $6
- Website
- https://www.rtcsnv.com
- Schedules at
- https://www.rtcsnv.com/ways-to-travel/schedules-maps/
- Phone
- +1 866 691 9732
- eplasales@eplalimo.com
- Website
- eplalimo.com
Bus from San Bernardino to Las Vegas, NV
- Ave. Duration
- 3h 45m
- Frequency
- Once daily
- Estimated price
- $40–60
- Schedules at
- eplalimo.com
- One Way
- $40–60
- Phone
- +1-800-231-2222
- ifsr@greyhound.com
- Website
- greyhound.com.mx
Bus from Santa Ana to Los Angeles Union Station
- Ave. Duration
- 1h
- Frequency
- 3 times a day
- Estimated price
- $10–14
- Schedules at
- greyhound.com.mx
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Los Angeles Union Station to Las Vegas Downtown
- Ave. Duration
- 5h 25m
- Frequency
- Twice daily
- Estimated price
- $35–70
- Schedules at
- flixbus.com
Bus from Anaheim Regional Transportation Intermodal Center to Las Vegas Strip
- Ave. Duration
- 7h 15m
- Frequency
- 3 times a week
- Estimated price
- $35–60
- Schedules at
- flixbus.com
- Phone
- +1 (951) 565-5002
- Website
- riversidetransit.com
Bus from Katella + Harbor to San Bernardino
- Ave. Duration
- 1h 57m
- Frequency
- Every 2 hours
- Estimated price
- $1–5
- Website
- http://www.riversidetransit.com
- Children 46" tall and under
- $1–4
- Seniors 60+, Disabled, Medicare
- $1–4
- Adults and children over 46" tall
- $1–5
- Phone
- +1 602-698-7800
- support@luxcoachamerica.com
- Website
- luxcoachamerica.com
Bus from San Bernardino to SB Las Vegas at Fashion Show Mall
- Ave. Duration
- 4h 29m
- Frequency
- 5 times a week
- Estimated price
- $45
- Schedules at
- luxcoachamerica.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide











