There are 4 ways to get from Santa Ana to Des Moines by plane, bus (Greyhound), train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from John Wayne Airport Orange County (SNA) to Des Moines (DSM)plane SNA - DSM
3h 35m$145–544Bus (Greyhound)
- Take the bus from Santa Ana Bus Stop to Las Vegas Bus Terminalbus
- Take the bus from Las Vegas Bus Terminal to Denver Union Stationbus
- Take the bus from Denver Union Station to Des Moinesbus
36h 40m$274–520Train, bus
- Take the train from Fullerton Amtrak Station to Kansas Citytrain Southwest Chief
- Take the bus from Kansas City to Des Moinesbus Jefferson 802 / ...
40h 35m$415–999Drive 1,679.8 mi
- Drive from Santa Ana to Des Moinescar 1,679.8 mi
26h 1m$307–443
Santa Ana to Des Moines by bus (Greyhound)
Questions & Answers
The cheapest way to get from Santa Ana to Des Moines is to fly which costs $140 - $550 and takes 3h 35m.
The fastest way to get from Santa Ana to Des Moines is to fly which takes 3h 35m and costs $140 - $550.
No, there is no direct bus from Santa Ana to Des Moines. However, there are services departing from Santa Ana Bus Stop and arriving at Des Moines via Las Vegas Bus Terminal and Denver Union Station. The journey, including transfers, takes approximately 36h 40m.
The distance between Santa Ana and Des Moines is 1446 miles. The road distance is 1689.6 miles.
The best way to get from Santa Ana to Des Moines without a car is to bus which takes 36h 40m and costs $270 - $550.
It takes approximately 3h 35m to get from Santa Ana to Des Moines, including transfers.
Santa Ana to Des Moines bus services, operated by Greyhound USA, depart from Santa Ana Bus Stop station.
The best way to get from Santa Ana to Des Moines is to fly which takes 3h 35m and costs $140 - $550. Alternatively, you can bus, which costs $270 - $550 and takes 36h 40m.
Santa Ana to Des Moines bus services, operated by Greyhound USA, arrive at Las Vegas Bus Terminal station.
Des Moines is 2h ahead of Santa Ana. It is currently 12:25 AM in Santa Ana and 2:25 AM in Des Moines.
What companies run services between Santa Ana, CA, USA and Des Moines, IA, USA?
Allegiant Air, Southwest Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Santa Ana Bus Stop to Des Moines via Las Vegas Bus Terminal and Denver Union Station in around 36h 40m.
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Des Moines via Phoenix
- Ave. Duration
- 4h 55m
- When
- Sunday
- Estimated price
- $100–500
Flights from John Wayne Airport Orange County to Des Moines via Denver
- Ave. Duration
- 5h
- When
- Tuesday and Wednesday
- Estimated price
- $100–490
Flights from John Wayne Airport Orange County to Des Moines via Las Vegas
- Ave. Duration
- 5h 40m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $100–490
- Website
- aa.com
Flights from John Wayne Airport Orange County to Des Moines via Phoenix
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $100–500
- Website
- united.com
Flights from John Wayne Airport Orange County to Des Moines via Denver
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $100–490
- Website
- allegiantair.com
Flights from John Wayne Airport Orange County to Des Moines
- Ave. Duration
- 3h 16m
- When
- Monday and Friday
- Estimated price
- $100–490
- Website
- flyfrontier.com
Flights from John Wayne Airport Orange County to Des Moines via Denver
- Ave. Duration
- 5h 10m
- When
- Monday, Friday, and Saturday
- Estimated price
- $100–490
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Fullerton Amtrak Station to Kansas City
- Ave. Duration
- 34h 31m
- Frequency
- Once daily
- Estimated price
- $390–900
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Santa Ana Bus Stop to Las Vegas Bus Terminal
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
Bus from Las Vegas Bus Terminal to Denver Union Station
- Ave. Duration
- 16h 5m
- Frequency
- Once daily
- Estimated price
- $120–230
- Website
- https://www.greyhound.com/
Bus from Denver Union Station to Des Moines
- Ave. Duration
- 13h
- Frequency
- Once daily
- Estimated price
- $110–210
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Kansas City to Des Moines
- Ave. Duration
- 3h
- Frequency
- Twice daily
- Estimated price
- $18–90
- Book at
- https://www.jeffersonlines.com
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Santa Ana to Des Moines is 1690 miles. It takes approximately 26h 1m to drive from Santa Ana to Des Moines.
Book your Santa Ana to Des Moines bus tickets online with FlixBus.
There are 252+ hotels available in Des Moines.











