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How to get fromSanta Ana to Buffaloby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

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There are 10 ways to get from Santa Ana to Buffalo by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly John Wayne Airport Orange County to Buffalo Niagara International Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF)plane plane SNA - BUF
    9h 3m
    $227–980

  2. Train to Los Angeles International Airport, fly to Buffalo Niagara International Airport

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Buffalo Niagara International Airport (BUF)plane plane LAX - BUF
    8h 54m
    $201–820

  3. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train Southwest Chief
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    2d 8h
    $1,499–2,499

  4. Bus

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Columbusbus bus
    4. Take the bus from Columbus to Buffalobus bus
    2d 13h
    $471–720

  5. Drive  2,528.1 mi

    1. Drive from Santa Ana to Buffalocar car 2,528.1 mi
    40h 12m
    $418–603

  6. Train to Burbank Bob Hope Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Buffalo Niagara International Airport (BUF)plane plane BUR - BUF
    10h 59m
    $230–917

  7. Fly Long Beach Airport to Buffalo Niagara International Airport

    1. Fly from Long Beach Airport (LGB) to Buffalo Niagara International Airport (BUF)plane plane LGB - BUF
    11h 32m
    $355–1,542

  8. Train, train to Ontario International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Ontario Amtraktrain train
    3. Fly from Ontario International Airport (ONT) to Buffalo Niagara International Airport (BUF)plane plane ONT - BUF
    11h 53m
    $276–1,094

  9. Train to Los Angeles International Airport, fly to Toronto Pearson International Airport, bus

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Toronto Pearson International Airport (YYZ)plane plane LAX - YYZ
    3. Take the bus from Toronto Pearson Airport to Buffalobus bus
    12h 36m
    $302–867

  10. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland to Buffalobus bus
    2d 8h
    $1,252–2,044

Santa Ana to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration2d 8hAverage Duration
Ticket$1,499Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Ana to Buffalo.ExpandLaunch map view
  • Distance: 2,209 mi
  • Duration: 9h 3m

What companies run services between Santa Ana, CA, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a train from Santa Ana to Buffalo via Fullerton Amtrak Station, Chicago Union Station, and Buffalo Depew Station in around 2d 8h.

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Train operators
Bus operators

Want to know more about travelling around United States

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