There are 3 ways to get from Santa Ana to Antigua Guatemala by bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  5 h 38 min

  1. Take the bus from Santa Ana to Guatemala City Holiday Inn
  2. Take the bus from Guatemala City to Antigua Guatemala

$37 - $88

Cheapest option

Bus via Guatemala El Trebol Zona 7  •  5 h 45 min

  1. Take the bus from Santa Ana to Guatemala City Holiday Inn

$32

1 alternative option

Drive  •  2 h 59 min

  1. Drive from Santa Ana to Antigua Guatemala 115.5 miles

$13 - $20

Questions & Answers

No, there is no direct bus from Santa Ana to Antigua Guatemala. However, there are services departing from Santa Ana and arriving at Antigua Guatemala via Guatemala City. The journey, including transfers, takes approximately 5 h 38 min.

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The distance between Santa Ana and Antigua Guatemala is 141 km. The road distance is 184.9 km.

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The best way to get from Santa Ana to Antigua Guatemala without a car is to bus which takes 5 h 38 min and costs .

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It takes approximately 5 h 38 min to get from Santa Ana to Antigua Guatemala, including transfers.

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Santa Ana to Antigua Guatemala bus services, operated by Pullmantur, depart from Santa Ana station.

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Santa Ana to Antigua Guatemala bus services, operated by Hedman Alas, arrive at Antigua Guatemala station.

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Yes, the driving distance between Santa Ana to Antigua Guatemala is 185 km. It takes approximately 2 h 59 min to drive from Santa Ana to Antigua Guatemala.

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There are 460+ hotels available in Antigua Guatemala. Prices start at $19 USD per night.

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Map of how to get from Santa Ana to Antigua Guatemala.
Launch map view
  • Distance: 88.4 miles
  • Duration: 5 h 38 min

What companies run services between Santa Ana, El Salvador and Antigua Guatemala?

You can take a bus from Santa Ana to Antigua Guatemala via Guatemala City Holiday Inn and Guatemala City in around 5 h 38 min.

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