There are 3 ways to get from Santa Ana to Antigua Guatemala by bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  5 h 38 min

  1. Take the bus from Santa Ana to Guatemala City Holiday Inn
  2. Take the bus from Guatemala City to Antigua Guatemala

$38 - $89

Cheapest option

Bus via Guatemala El Trebol Zona 7  •  5 h 45 min

  1. Take the bus from Santa Ana to Guatemala City Holiday Inn

$33

1 alternative option

Drive  •  2 h 59 min

  1. Drive from Santa Ana to Antigua Guatemala 115.5 miles

$13 - $20

Questions & Answers

The cheapest way to get from Santa Ana to Antigua Guatemala is to drive which costs $13 - $20 and takes 2 h 59 min.

More details

The quickest way to get from Santa Ana to Antigua Guatemala is to drive which costs $13 - $20 and takes 2 h 59 min.

More details

The distance between Santa Ana and Antigua Guatemala is 141 km. The road distance is 184.9 km.

Get driving directions

It takes approximately 5 h 38 min to get from Santa Ana to Antigua Guatemala, including transfers.

More details

No, there is no direct bus from Santa Ana to Antigua Guatemala. However, there are services departing from Santa Ana and arriving at Antigua Guatemala via Guatemala City. The journey, including transfers, takes approximately 5 h 38 min.

More details

What companies run services between Santa Ana, El Salvador and Antigua Guatemala?

You can take a bus from Santa Ana to Antigua Guatemala via Guatemala City Holiday Inn and Guatemala City in around 5 h 38 min.

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