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There are 5 ways to get from Santa Ana to Mexicali by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus ABC  •  5h 38m

  1. Take the bus from Santa Ana, Ca to San Ysidro, Ca 9493 / ...
  2. Take the bus from Tijuana to Mexicali

$32 - $59

4 alternative options

Train, bus  •  6h 4m

  1. Take the train from Santa Ana Amtrak Station to San Diego Santa Fe Depot Pacific Surfliner
  2. Take the bus from Tijuana to Mexicali

$47 - $86

Bus ACN Autobuses  •  6h 18m

  1. Take the bus from Santa Ana to Tijuana Buenavista 606 Aeropuerto Tijuana / ...
  2. Take the bus from Tijuana Buenavista to Mexicali 2102 Ensenada / ...

Drive  •  3h 33m

  1. Drive from Santa Ana to Mexicali 206.6 miles

$20 - $30

Train, fly  •  5h 26m

  1. Take the train from Santa Ana Amtrak Station to Los Angeles Union Station
  2. Fly from Los Angeles (LAX) to El Centro (IPL) LAX - IPL

$60 - $164

Questions & Answers

The cheapest way to get from Santa Ana to Mexicali is to drive which costs $20 - $30 and takes 3h 33m.

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The quickest way to get from Santa Ana to Mexicali is to drive which costs $20 - $30 and takes 3h 33m.

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No, there is no direct bus from Santa Ana to Mexicali. However, there are services departing from Santa Ana, Ca and arriving at Mexicali via Tijuana. The journey, including transfers, takes approximately 5h 38m.

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The distance between Santa Ana and Mexicali is 160 miles. The road distance is 206.6 miles.

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The best way to get from Santa Ana to Mexicali without a car is to bus which takes 5h 38m and costs $30 - $60.

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It takes approximately 5h 38m to get from Santa Ana to Mexicali, including transfers.

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Santa Ana to Mexicali bus services, operated by Greyhound USA, depart from Santa Ana, Ca station.

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The quickest flight from Los Angeles Airport to El Centro Airport is the direct flight which takes 1h 30m.

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Santa Ana to Mexicali bus services, operated by ABC, arrive at Mexicali station.

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Yes, the driving distance between Santa Ana to Mexicali is 207 miles. It takes approximately 3h 33m to drive from Santa Ana to Mexicali.

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Map of how to get from Santa Ana to Mexicali.
Launch map view
  • Distance: 160.4 miles
  • Duration: 5h 38m

What companies run services between Santa Ana, CA, USA and Mexicali, Mexico?

You can take a bus from Santa Ana to Mexicali via San Ysidro, Ca and Tijuana in around 5h 38m.

Airlines
Mokulele
Website
mokuleleairlines.com
Flights from Los Angeles to El Centro
Ave. Duration
1h 30m
When
Every day
Estimated price
$45 - $180
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Santa Ana Amtrak Station to San Diego Santa Fe Depot
Ave. Duration
2h 4m
Frequency
Every 2 hours
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Train from Santa Ana Amtrak Station to Los Angeles Union Station
Ave. Duration
59m
Frequency
Every 2 hours
Estimated price
$22 - $45
Website
amtrak.com
Coach Seat
$22 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$29 - $45
Room
$130 - $190
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Santa Ana, Ca to San Ysidro, Ca
Ave. Duration
2h 35m
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from Santa Ana to San Ysidro
Ave. Duration
2h 21m
Frequency
Twice daily
Estimated price
$40 - $60
Schedules at
greyhound.com.mx
ACN Autobuses
Phone
(01)66429904887
Email
clientes@acnautobuses.com
Website
acnautobuses.com
Bus from Santa Ana to San Ysidro
Ave. Duration
2h 47m
Frequency
Twice daily
Schedules at
acnautobuses.com
Bus from Santa Ana to Tijuana Buenavista
Ave. Duration
2h 55m
Frequency
3 times a day
Schedules at
acnautobuses.com
Bus from Tijuana Buenavista to Mexicali
Ave. Duration
2h 23m
Frequency
3 times a day
Schedules at
acnautobuses.com
ABC
Website
abc.com.mx
Bus from Tijuana to Mexicali
Ave. Duration
2h 30m
Frequency
Hourly
Estimated price
$15 - $22
Schedules at
reservamos.mx
Book at
reservamos.mx
Aguacaliente
Phone
6646212955
Email
atencionaclientes@autobusesaguacaliente.com.mx
Website
autobusesaguacaliente.com.mx
Bus from Tijuana to Mexicali
Ave. Duration
2h
Frequency
Every 2 hours
Estimated price
$17
Schedules at
autobusesaguacaliente.com.mx

Want to know more about travelling around Mexico

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Mokulele offers flights from Los Angeles Airport to El Centro Airport.

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There are 48+ hotels available in Mexicali. Prices start at $38 USD per night.

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