There are 6 ways to get from Santa Ana to Mexicali by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus ABC  •  5 h 38 min

  1. Take the bus from Santa Ana, Ca to San Ysidro, Ca 9493 / ...
  2. Take the bus from Tijuana to Mexicali

$32 - $59

5 alternative options

Train, bus  •  6 h 6 min

  1. Take the train from Santa Ana Regional Transportation Center Amtrak to San Diego Santa Fe Depot Pacific Surfliner
  2. Take the bus from Tijuana to Mexicali

$47 - $86

Bus  •  6 h 29 min

  1. Take the bus from Santa Ana, Ca to Tijuana Central Bus Term, Mx 9489 / ...
  2. Take the bus from Tijuana Bus Terminal to Mexicali Bus Terminal Tijuana-Nuevo Laredo / ...

$32 - $99

Drive  •  3 h 33 min

  1. Drive from Santa Ana to Mexicali 206.6 miles

$20 - $30

Train to Los Angeles, fly to El Centro  •  5 h 23 min

  1. Take the train from Santa Ana Regional Transportation Center Amtrak to Los Angeles Union Station Amtrak
  2. Fly from Los Angeles (LAX) to El Centro (IPL) LAX - IPL

$66 - $172

Fly Santa Ana to Yuma, bus  •  8 h 3 min

  1. Fly from Santa Ana (SNA) to Yuma (YUM) SNA - YUM
  2. Take the bus from San Luis Rio Colorado to Mexicali Bus Terminal

$162 - $772

Questions & Answers

The cheapest way to get from Santa Ana to Mexicali is to drive which costs $20 - $30 and takes 3 h 33 min.

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The quickest way to get from Santa Ana to Mexicali is to drive which costs $20 - $30 and takes 3 h 33 min.

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No, there is no direct bus from Santa Ana to Mexicali. However, there are services departing from Santa Ana, Ca and arriving at Mexicali via Tijuana. The journey, including transfers, takes approximately 5 h 38 min.

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The distance between Santa Ana and Mexicali is 160 miles. The road distance is 206.6 miles.

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The best way to get from Santa Ana to Mexicali without a car is to bus which takes 5 h 38 min and costs $30 - $60.

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It takes approximately 5 h 38 min to get from Santa Ana to Mexicali, including transfers.

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Santa Ana to Mexicali bus services, operated by Greyhound USA, depart from Santa Ana, Ca station.

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The quickest flight from Los Angeles Airport to El Centro Airport is the direct flight which takes 1 h 25 min.

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Santa Ana to Mexicali bus services, operated by ABC, arrive at Mexicali station.

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Yes, the driving distance between Santa Ana to Mexicali is 207 miles. It takes approximately 3 h 33 min to drive from Santa Ana to Mexicali.

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Map of how to get from Santa Ana to Mexicali.
Launch map view
  • Distance: 160.4 miles
  • Duration: 5 h 38 min

What companies run services between Santa Ana, CA, USA and Mexicali, Mexico?

You can take a bus from Santa Ana to Mexicali via San Ysidro, Ca and Tijuana in around 5 h 38 min.

Airlines
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from Santa Ana to Yuma via Phoenix
Ave. Duration
3 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$150 - $750
Flights from Santa Ana to Yuma via San Jose, Phoenix
Ave. Duration
6 h 6 min
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $850
American Airlines
Website
aa.com
Flights from Santa Ana to Yuma via Phoenix
Ave. Duration
3 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$150 - $750
Mokulele
Website
mokuleleairlines.com
Flights from Los Angeles to El Centro
Ave. Duration
1 h 25 min
When
Every day
Estimated price
$45 - $180
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Santa Ana Regional Transportation Center Amtrak to San Diego Santa Fe Depot
Ave. Duration
2 h 6 min
Frequency
Every 2 hours
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Train from Santa Ana Regional Transportation Center Amtrak to Los Angeles Union Station Amtrak
Ave. Duration
1 h 1 min
Frequency
Every 2 hours
Estimated price
$22 - $45
Website
amtrak.com
Coach Seat
$22 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$29 - $45
Room
$130 - $190
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Santa Ana, Ca to San Ysidro, Ca
Ave. Duration
2 h 35 min
Frequency
Every 30 minutes
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Santa Ana, Ca to Tijuana Central Bus Term, Mx
Ave. Duration
3 h 25 min
Frequency
Every 30 minutes
Estimated price
$17 - $40
Website
greyhound.com
Economy
$17 - $26
Flexible
$30 - $40
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from Santa Ana to San Ysidro
Ave. Duration
2 h 21 min
Frequency
Once daily
Estimated price
$40 - $60
Schedules at
greyhound.com.mx
Bus from Santa Ana to Tijuana
Ave. Duration
3 h 6 min
Frequency
Once daily
Estimated price
$40 - $60
Schedules at
greyhound.com.mx
Bus from Tijuana Bus Terminal to Mexicali
Ave. Duration
2 h 45 min
Frequency
5 times a day
Estimated price
$40 - $60
Schedules at
greyhound.com.mx
ABC
Website
abc.com.mx
Bus from Tijuana to Mexicali
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$15 - $22
Schedules at
reservamos.mx
Book at
reservamos.mx
Bus from San Luis Rio Colorado to Mexicali Bus Terminal
Ave. Duration
1 h 15 min
Frequency
Every 2 hours
Estimated price
$6 - $10
Schedules at
reservamos.mx
Book at
reservamos.mx
Aguacaliente
Phone
6646212955
Email
atencionaclientes@autobusesaguacaliente.com.mx
Website
autobusesaguacaliente.com.mx
Bus from Tijuana to Mexicali
Ave. Duration
2 h
Frequency
Every 2 hours
Estimated price
$18
Schedules at
autobusesaguacaliente.com.mx
TAP
Website
tap.com.mx
Bus from Tijuana Bus Terminal to Mexicali Bus Terminal
Ave. Duration
2 h 40 min
Frequency
Hourly
Estimated price
$15 - $21
Schedules at
tap.com.mx
Confort
$15 - $21
Tufesa
Phone
7022546899
Email
serviciosvegas@hotmail.com
Website
tufesabus.com
Bus from San Luis Río Colorado to Mexicali Bus Terminal
Ave. Duration
54 min
Frequency
Every 4 hours
Estimated price
$6 - $14
Book at
GotoBus
Plus
$6 - $10
Platinum
$10 - $14
Ejecutivo
$10 - $14

Want to know more about travelling around Mexico

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More Questions & Answers

Mokulele offers flights from Los Angeles Airport to El Centro Airport.

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There are 45+ hotels available in Mexicali. Prices start at $39 USD per night.

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The best way to get from Santa Ana to Santa Ana Airport is to bus which takes 20 min and costs $2 - $4.

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