There are 6 ways to get from Sanibel to Key Largo by bus (Flixbus, Greyhound), car, taxi, plane, shuttle, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus FlixBus 2421
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus Greyhound US0720s
6h 8m$81–125Drive 184.7 mi
cheapest- Drive from Sanibel to Key Largocar 184.7 mi
3h 51m$34–49Taxi to Ft. Myers, fly, shuttle
- Take the taxi from Sanibel to Ft-Myers-Airport-RSWtaxi
- Fly from Ft. Myers (RSW) to Miami International Airport (MIA)plane RSW - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
6h 4m$183–522Taxi, bus
- Take the taxi from Sanibel to Naples, FLtaxi
- Take the bus from Naples, FL to Fort Lauderdale Airportbus
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus
6h 34m$137–283Bus via Homestead
- Take the bus from Fort Myers to Miamibus Houston
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
8h 5mBus to Tampa, fly, shuttle
- Take the bus from Fort Myers 7-11 to Tampa International Airportbus
- Fly from Tampa (TPA) to Miami International Airport (MIA)plane TPA - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
7h 24m$251–682
Ft. Myers (RSW) to Miami International Airport (MIA) flights
Questions & Answers
The cheapest way to get from Sanibel to Key Largo is to drive which costs $30 - $50 and takes 3h 51m.
The fastest way to get from Sanibel to Key Largo is to drive which takes 3h 51m and costs $30 - $50.
The distance between Sanibel and Key Largo is 237 miles. The road distance is 185.8 miles.
The best way to get from Sanibel to Key Largo without a car is to bus which takes 6h 8m and costs $80 - $130.
It takes approximately 6h 8m to get from Sanibel to Key Largo, including transfers.
Yes, the driving distance between Sanibel to Key Largo is 186 miles. It takes approximately 3h 51m to drive from Sanibel to Key Largo.
There are 261+ hotels available in Key Largo.
What companies run services between Sanibel, FL, USA and Key Largo, FL, USA?
You can take a vehicle from Sanibel to Key Largo Bus Stop via Fort Myers Bus Stop and Miami Airport Station in around 6h 8m.
- Website
- aa.com
Flights from Ft. Myers to Miami International Airport via Charlotte
- Ave. Duration
- 6h 30m
- When
- Every day
- Estimated price
- $110–550
Flights from Tampa to Miami International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $35–260
- Website
- delta.com
Flights from Ft. Myers to Miami International Airport via Atlanta
- Ave. Duration
- 5h 38m
- When
- Every day
- Estimated price
- $100–500
- Website
- southwest.com
Flights from Ft. Myers to Miami International Airport via Orlando
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $50–350
- Website
- flyfrontier.com
Flights from Ft. Myers to Miami International Airport via Atlanta
- Ave. Duration
- 5h 11m
- When
- Thursday and Sunday
- Estimated price
- $100–500
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Fort Myers Bus Stop to Miami Airport Station
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a day
- Estimated price
- $25–55
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Key Largo Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- 3 times a day
- Estimated price
- $14–21
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 4 times a day
- Estimated price
- $80–110
- Website
- https://www.keysshuttle.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Naples, FL to Fort Lauderdale Airport
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $22–140
- Website
- https://www.redcoachusa.com
- Web
- $22–140
Bus from Fort Myers 7-11 to Tampa International Airport
- Ave. Duration
- 2h 20m
- Frequency
- 5 times a week
- Estimated price
- $23–140
- Website
- https://www.redcoachusa.com
- Web
- $23–140
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Fort Myers to Miami
- Ave. Duration
- 3h 36m
- Frequency
- Once daily
- Estimated price
- $50–70
- Schedules at
- omnibusexpress.com
- Phone
- +1 786-469-5675
- Website
- miamidade.gov
Bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Website
- https://www.miamidade.gov/global/transportation/home.page
- Ave. Duration
- 47 min
- Estimated price
- $50–120
Island Taxi
- Phone
- +1 239-472-4888
- Website
- islandtaxi.com
Island Taxi
- Phone
- +1 239-472-4888
- Website
- islandtaxi.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide















