Avianca - Aerov�as del Continente Americano S.A. and Skytrans fly from San Salvador to Guatemala City 4 times a day. Alternatively, Tica Bus operates a bus from San Salvador to Guatemala City twice daily. Tickets cost $19 - $26 and the journey takes 6 h. Transmetro also services this route every 5 minutes.
From San Salvador drive to San Salvador airport, fly to Guatemala City airport, then bus to Guatemala City. 1 h 52 min $124. From San Salvador Tica Bus San Carlos bus to Guatemala City, walk to Reformita, then bus to Plaza Barrios. 6 h 34 min $23. From San Salvador bus to Guatemala City. 7 h $22. From San Salvador drive to Guatemala City. 3 h 39 min $21.