There are 7 ways to get from San Pedro de Atacama to Santa Cruz de la Sierra by bus, taxi, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, taxi, train  •  33 h 59 min

  1. Take the bus from San Pedro de Atacama to Purmamarca
  2. Take a taxi from Purmamarca to Ledesma
  3. Take the bus from Ledesma to Orán
  4. Take the bus from San Ramón de la Nueva Orán to Salvador Mazza
  5. Take the train from Yacuiba to Santa Cruz de la Sierra - Terminal bimodal

$83 - $126

Cheapest option

Bus Trans Salvador  •  34 h 7 min

  1. Take the bus from San Pedro de Atacama to Calama
  2. Take the bus from Calama to Santa Cruz de la Sierra

$39 - $69

5 alternative options

Bus via Uyuni  •  34 h 30 min

  1. Take the bus from San Pedro de Atacama to Uyuni
  2. Take the bus from Uyuni to Sucre
  3. Take the bus from Sucre to Santa Cruz

$49 - $69

Drive  •  18 h 32 min

  1. Drive from San Pedro de Atacama to Santa Cruz de la Sierra 864.5 miles

$140 - $210

Bus, bus to Uyuni, fly  •  12 h 54 min

  1. Take the bus from San Pedro de Atacama to Calama
  2. Take the bus from Calama to Uyuni
  3. Fly from Uyuni (UYU) to Santa Cruz (VVI) UYU - VVI

$135 - $316

Bus, Minibus to Iquique, fly  •  13 h 11 min

  1. Take the bus from San Pedro de Atacama to Calama
  2. Take the bus from Calama to La Tirana
  3. Take the Minibus from Pica to Iquique Airport
  4. Fly from Iquique (IQQ) to Santa Cruz (VVI) IQQ - VVI

Bus, bus to Salta, fly  •  17 h 37 min

  1. Take the bus from San Pedro de Atacama to San Salvador de Jujuy
  2. Take the bus from San Salvador de Jujuy to Salta
  3. Fly from Salta (SLA) to Santa Cruz (VVI) SLA - VVI

$203 - $1,350

Questions & Answers

The cheapest way to get from San Pedro de Atacama to Santa Cruz de la Sierra is to bus which costs $35 - $70 and takes 34 h 7 min.

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The quickest way to get from San Pedro de Atacama to Santa Cruz de la Sierra is to bus and fly which costs $130 - $320 and takes 12 h 54 min.

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No, there is no direct bus from San Pedro de Atacama to Santa Cruz de la Sierra. However, there are services departing from San Pedro de Atacama and arriving at Santa Cruz de la Sierra via Calama. The journey, including transfers, takes approximately 34 h 7 min.

More details

The distance between San Pedro de Atacama and Santa Cruz de la Sierra is 773 km. The road distance is 1383.2 km.

Get driving directions

The best way to get from San Pedro de Atacama to Santa Cruz de la Sierra without a car is to bus which takes 34 h 7 min and costs $35 - $70.

More details

It takes approximately 33 h 59 min to get from San Pedro de Atacama to Santa Cruz de la Sierra, including transfers.

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San Pedro de Atacama to Santa Cruz de la Sierra bus services, operated by Frontera del Norte, depart from San Pedro de Atacama station.

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The quickest flight from Uyuni Airport to Santa Cruz Airport is the direct flight which takes 1 h 15 min.

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San Pedro de Atacama to Santa Cruz de la Sierra bus services, operated by Trans Salvador, arrive at Santa Cruz de la Sierra station.

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Yes, the driving distance between San Pedro de Atacama to Santa Cruz de la Sierra is 1383 km. It takes approximately 18 h 32 min to drive from San Pedro de Atacama to Santa Cruz de la Sierra.

Get driving directions

Amaszonas offers flights from Uyuni Airport to Santa Cruz Airport.

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There are 229+ hotels available in Santa Cruz de la Sierra. Prices start at $28 USD per night.

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Map of how to get from San Pedro de Atacama to Santa Cruz de la Sierra.
Launch map view
  • Distance: 483.4 miles
  • Duration: 33 h 59 min

What companies run services between San Pedro de Atacama, Chile and Santa Cruz de la Sierra, Bolivia?

You can take a bus from San Pedro de Atacama to Santa Cruz de la Sierra via Calama and Calama in around 34 h 7 min.

Airlines
Amaszonas
Website
amaszonas.com
Flights from Uyuni to Santa Cruz
Ave. Duration
1 h 15 min
When
Monday, Wednesday, Friday and Sunday
Estimated price
$110 - $900
Flights from Uyuni to Santa Cruz via La Paz
Ave. Duration
3 h 20 min
When
Every day
Estimated price
$110 - $900
Flights from Iquique to Santa Cruz
Ave. Duration
1 h 35 min
When
Monday, Wednesday, Friday and Sunday
Estimated price
$240 - $600
Flights from Iquique to Santa Cruz via La Paz
Ave. Duration
3 h 45 min
When
Tuesday, Thursday and Saturday
Estimated price
$280 - $700
Boliviana de Aviación
Website
boa.bo
Flights from Salta to Santa Cruz
Ave. Duration
1 h 30 min
When
Tuesday, Thursday and Saturday
Estimated price
$190 - $1,200
Train operators
Ferroviaria Oriental S.A
Phone
(+591) 3 3387000
Website
fo.com.bo
Train from Yacuiba to Santa Cruz de la Sierra - Terminal bimodal
Ave. Duration
16 h 55 min
Frequency
Once a week
Estimated price
$9
Schedules at
fo.com.bo
Book at
ticketsbolivia.com.bo
Bus operators
Andesmar
Phone
1 786 233 7639
Email
gestionesatc@andesmar.com.ar
Website
andesmar.com
Bus from San Pedro de Atacama to Purmamarca
Ave. Duration
8 h 15 min
Frequency
6 times a week
Estimated price
$14 - $35
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$14 - $22
Executive
$14 - $20
Suite
$20 - $24
Semi Cama
$27
Cama
$35
Bus from San Pedro de Atacama to San Salvador de Jujuy
Ave. Duration
10 h 15 min
Frequency
6 times a week
Estimated price
$15 - $40
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$15 - $23
Executive
$16 - $23
Suite
$23 - $26
Semi Cama
$29
Cama
$37
Buses Lep
Phone
(+54) 351-246 6600, (+54) 0351-5696600, (+54) 0358-4219090
Email
expreso@buseslep.com.ar
Website
buseslep.com.ar
Bus from Ledesma to Orán
Ave. Duration
1 h 3 min
Frequency
Twice daily
Estimated price
$3 - $7
Schedules at
buseslep.com.ar
Book at
buseslep.plataforma10.com.ar
Regular
$3 - $6
Premium
$5 - $7
Bus from San Ramón de la Nueva Orán to Salvador Mazza
Ave. Duration
2 h 43 min
Frequency
Every 4 hours
Estimated price
$6 - $10
Schedules at
buseslep.com.ar
Book at
buseslep.plataforma10.com.ar
Regular
$6 - $9
Premium
$8 - $10
Frontera del Norte
Phone
+56 065-280 999 / 9 6633 7480
Website
facebook.com
Bus from San Pedro de Atacama to Calama
Ave. Duration
1 h 30 min
Frequency
Every 3 hours
Estimated price
$4
Schedules at
recorrido.cl
Atacama 2000
Phone
+ 56 55 31 6664
Bus from San Pedro de Atacama to Calama
Ave. Duration
1 h 30 min
Frequency
4 times a day
Estimated price
$5
Schedules at
voyhoy.com
Book at
voyhoy.com
Bus from Calama to Uyuni
Ave. Duration
8 h 30 min
Frequency
4 times a week
Estimated price
$15
Schedules at
voyhoy.com
Book at
voyhoy.com
Trans Salvador
Phone
+56 58 222 8547
Email
central@trans-salvador.com
Website
trans-salvador.com
Bus from Calama to Santa Cruz de la Sierra
Ave. Duration
31 h 30 min
Frequency
3 times a week
Estimated price
$35 - $65
Schedules at
trans-salvador.com
Book at
ticketsbolivia.com.bo
Semi Bed
$35 - $50
Premium
$50 - $60
Bus from Calama to Uyuni
Ave. Duration
7 h 30 min
Frequency
Once daily
Estimated price
$11 - $19
Schedules at
trans-salvador.com
Book at
ticketsbolivia.com.bo
Semi Bed
$11 - $15
Premium
$15 - $19
Trans 6 de Octubre
Phone
+591 79576765
Bus from Uyuni to Sucre
Ave. Duration
7 h
Frequency
Once daily
Estimated price
$18
Schedules at
ticketsbolivia.com.bo
Book at
ticketsbolivia.com.bo
Bus from Sucre to Santa Cruz
Ave. Duration
12 h 30 min
Frequency
3 times a day
Estimated price
$19
Schedules at
ticketsbolivia.com.bo
Book at
ticketsbolivia.com.bo
Todo Turismo
Phone
+(591) 2228 7038
Email
atencionalcliente@todoturismosrl.com
Website
todoturismosrl.com
Bus from Uyuni to Sucre Bus Terminal
Ave. Duration
12 h 30 min
Frequency
Once daily
Schedules at
todoturismosrl.com
Book at
todoturismosrl.com
Trans Caminante SRL
Phone
+591 71162388 Santa Cruz / 4 6429385 Sucre
Website
facebook.com
Bus from Sucre to Santa Cruz - Terminal Bimodal
Ave. Duration
13 h 30 min
Frequency
Twice daily
Estimated price
$13
Schedules at
facebook.com
El Mexicano
Phone
+591 67640155
Website
facebook.com
Bus from Sucre to Santa Cruz - Terminal Bimodal
Ave. Duration
13 h
Frequency
Once daily
Estimated price
$15
Schedules at
facebook.com
Flota Bolivar
Phone
+591 2 2281973 La Paz / 4 4221819 Cochabamba / 3 3625458 Santa Cruz / 4 6453849 Sucre / 4 6830856 Yacuiba
Website
facebook.com
Bus from Sucre to Santa Cruz
Ave. Duration
13 h
Frequency
Once daily
Estimated price
$12 - $19
Schedules at
facebook.com
Kenny Bus
Phone
+56 22 570 8687
Email
ayuda@pasajebus.com
Website
kennybus.cl
Bus from Calama to La Tirana
Ave. Duration
2 h 30 min
Frequency
Twice daily
Schedules at
kennybus.cl
Minibus
Bus from Pica to Iquique Airport
Ave. Duration
2 h
Frequency
Twice daily
Estimated price
$9
Balut
Phone
+54 0810-888-2258
Email
info@baluthermanos.com.ar
Website
balutsrl.com.ar
Bus from San Salvador de Jujuy to Salta
Ave. Duration
2 h 10 min
Frequency
5 times a day
Estimated price
$2 - $6
Schedules at
balutsrl.com.ar
Book at
balutsrl.com.ar
Semi Cama
$2 - $4
Suite
$4 - $6
Flecha Bus
Phone
+54 011 4000 5200
Email
atencionalcliente@flechabus.com.ar
Website
flechabus.com.ar
Bus from San Salvador de Jujuy to Salta
Ave. Duration
1 h 30 min
Frequency
Twice daily
Estimated price
$3 - $6
Schedules at
centraldepasajes.com.ar
Book at
centraldepasajes.com.ar
Economy
$3 - $5
Executive
$4 - $5
Suite
$4 - $6
Other operators
Taxi from Purmamarca to Ledesma
Ave. Duration
1 h 58 min
Estimated price
$50 - $65
Remis Mario
Phone
+54 3881 568-25450
Website
elpibetilcara.com
Centro Remis Tilcara
Phone
+54 3881 540-41381
Website
centroremistilcara.com
Taxi Ya
Phone
+54 3884 192-192
Website
facebook.com

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