There are 6 ways to get from San Luis to Santiago by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus Tas-Choapa  •  10 h 25 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal Cordoba / ...
  2. Take the bus from Mendoza to Santiago Mendoza

$35 - $48

Cheapest option

Bus via Santiago  •  11 h 25 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal Cordoba / ...
  2. Take the bus from Mendoza to Santiago Mendoza

$11 - $68

4 alternative options

Bus Andesmar  •  12 h 35 min

  1. Take the bus from San Luis to Mendoza Cordoba / ...
  2. Take the bus from Mendoza to Santiago de Chile To Santiago

$19 - $37

Drive  •  7 h 23 min

  1. Drive from San Luis to Santiago 387.7 miles

$65 - $100

Fly from San Luis  •  7 h 59 min

  1. Fly from San Luis (LUQ) to Santiago (SCL) LUQ - SCL

$252 - $747

Bus to Mendoza, fly  •  7 h 15 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal
  2. Fly from Mendoza (MDZ) to Santiago (SCL) MDZ - SCL

$78 - $408

Questions & Answers

The cheapest way to get from San Luis to Santiago is to bus which costs $420 - $2600 and takes 11 h 25 min.

More details

The quickest way to get from San Luis to Santiago is to bus and fly which costs $2900 - $16000 and takes 7 h 15 min.

More details

No, there is no direct bus from San Luis to Santiago. However, there are services departing from San Luis and arriving at Santiago via Mendoza. The journey, including transfers, takes approximately 10 h 25 min.

More details

The distance between San Luis and Santiago is 401 km. The road distance is 620.3 km.

Get driving directions

The best way to get from San Luis to Santiago without a car is to bus which takes 10 h 25 min and costs $1300 - $1900.

More details

It takes approximately 10 h 25 min to get from San Luis to Santiago, including transfers.

More details

San Luis to Santiago bus services, operated by Cata International, depart from San Luis station.

More details

The best way to get from San Luis to Santiago is to bus which takes 10 h 25 min and costs $1300 - $1900. Alternatively, you can fly, which costs $9500 - $29000 and takes 7 h 59 min.

Mode details

There is no direct flight from San Luis Airport to Santiago Airport. The quickest flight takes 7 h 15 min and has one stopover.

Search flights

San Luis to Santiago bus services, operated by Tas-Choapa, arrive at Santiago station.

More details

Santiago is 1 h behind San Luis. It is currently 10:26 PM in San Luis and 10:26 PM in Santiago.

Yes, the driving distance between San Luis to Santiago is 620 km. It takes approximately 7 h 23 min to drive from San Luis to Santiago.

Get driving directions

Map of how to get from San Luis to Santiago.
Launch map view
  • Distance: 250.5 miles
  • Duration: 10 h 25 min

What companies run services between San Luis, Argentina and Santiago, Chile?

You can take a bus from San Luis to Santiago via Mendoza, Bus Terminal and Mendoza in around 10 h 25 min. Alternatively, Aerolíneas Argentinas flies from San Luis to Santiago twice daily.

Airlines
Aerolíneas Argentinas
Website
aerolineas.com.ar
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery
Ave. Duration
10 h 57 min
When
Every day
Estimated price
$240 - $700
LATAM Chile
Website
latam.com
Flights from Mendoza to Santiago
Ave. Duration
1 h 3 min
When
Every day
Estimated price
$150 - $480
Sky Airline
Website
skyairline.com
Flights from Mendoza to Santiago
Ave. Duration
1 h
When
Every day
Estimated price
$55 - $330
Bus operators
Cata International
Phone
0800-122-2282
Email
atencionalcliente@catainternacional.com
Website
catainternacional.com
Bus from San Luis to Mendoza, Bus Terminal
Ave. Duration
3 h 25 min
Frequency
Every 4 hours
Estimated price
$5 - $13
Schedules at
catainternacional.com
Promo Semi Cama
$5 - $7
Semi Cama
$7 - $10
Cama
$10 - $13
Suite
$9 - $13
Bus from Mendoza to Santiago
Ave. Duration
7 h
Frequency
5 times a day
Estimated price
$6 - $50
Schedules at
catainternacional.com
Book at
catainternacional.com
Promo Semi Cama
$6 - $10
Semi Cama
$10 - $13
Cama
$13 - $16
Suite
$12 - $18
Andesmar
Phone
1 786 233 7639
Email
gestionesatc@andesmar.com.ar
Website
andesmar.com
Bus from San Luis to Mendoza
Ave. Duration
3 h 20 min
Frequency
4 times a day
Estimated price
$9 - $18
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$12 - $18
Executive
$9 - $14
Suite
$15 - $17
Bus from Mendoza to Santiago de Chile
Ave. Duration
8 h
Frequency
Once daily
Estimated price
$12 - $24
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$14 - $21
Executive
$12 - $18
Suite
$18 - $21
San Juan Mar del Plata
Phone
[054] (0264) -4212405
Email
atencionalcliente@sanjuanmardelplata.com.ar
Website
sanjuanmardelplata.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 30 min
Frequency
Once daily
Estimated price
$8 - $15
Schedules at
sanjuanmardelplata.com.ar
Book at
sanjuanmardelplata.centraldepasajes.com.ar
Regular
$8 - $12
Executive
$10 - $15
El Rapido Internacional
Phone
1-305-677-0535
Email
info@elrapidoint.com.ar
Website
elrapidoint.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 35 min
Frequency
Once daily
Estimated price
$7 - $12
Schedules at
elrapidoint.com.ar
Book at
elrapidoint.com.ar
Promo Semi Cama
$8 - $9
Semi Cama
$7 - $10
Cama
$10 - $12
Bus from San Luis to Mendoza
Ave. Duration
3 h 35 min
Frequency
Twice daily
Estimated price
$7 - $12
Schedules at
elrapidoint.com.ar
Book at
elrapidoint.com.ar
Promo Semi Cama
$7 - $9
Semi Cama
$7 - $10
Cama
$10 - $12
Tas-Choapa
Phone
+54 261 431-2140
Website
taschoapa.cl
Bus from Mendoza to Santiago
Ave. Duration
6 h
Frequency
Once daily
Estimated price
$30
Schedules at
taschoapa.cl
COITRAM
Phone
+54261 431-1999
Email
gestionesatc@andesmar.com.ar
Website
andesmar.com
Bus from Mendoza to Santiago
Ave. Duration
7 h
Frequency
Twice a week
Estimated price
$19
Schedules at
andesmar.com
Book at
andesmar.com
Chevallier
Phone
(011) 4000-5255
Website
nuevachevallier.com
Bus from San Luis to Mendoza
Ave. Duration
3 h 10 min
Frequency
Once daily
Estimated price
$7 - $13
Schedules at
nuevachevallier.com
Book at
nuevachevallier.com
SemiCama
$7 - $10
Cama
$10 - $13
Suite
$10 - $12

Want to know more about travelling around the world?

Rome2rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Travelling to and around Russia for the 2018 FIFA World Cup, How to plan an amazing trip around Scandinavia and How to get from Southend Airport into central London - to help you get the most out of your next trip.

Where to next?