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There are 6 ways to get from San Luis to Santiago by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus Tas-Choapa  •  10 h 45 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal Cordoba / ...
  2. Take the bus from Mendoza to Santiago Mendoza

$37 - $51

Cheapest option

Bus Andesmar  •  12 h 35 min

  1. Take the bus from San Luis to Mendoza Cordoba / ...
  2. Take the bus from Mendoza to Santiago de Chile To Santiago

$21 - $44

4 alternative options

Bus via Santiago  •  11 h 45 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal Cordoba / ...
  2. Take the bus from Mendoza to Santiago Mendoza

$24 - $49

Drive  •  7 h 23 min

  1. Drive from San Luis to Santiago 387.7 miles

$65 - $100

Fly from San Luis  •  8 h 25 min

  1. Fly from San Luis (LUQ) to Santiago (SCL) LUQ - SCL

$252 - $747

Bus to Mendoza, fly  •  7 h 35 min

  1. Take the bus from San Luis to Mendoza, Bus Terminal
  2. Fly from Mendoza (MDZ) to Santiago (SCL) MDZ - SCL

$80 - $411

Questions & Answers

The cheapest way to get from San Luis to Santiago is to bus which costs $750 - $1700 and takes 12 h 35 min.

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The quickest way to get from San Luis to Santiago is to drive which costs $2400 - $3600 and takes 7 h 23 min.

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No, there is no direct bus from San Luis to Santiago. However, there are services departing from San Luis and arriving at Santiago via Mendoza. The journey, including transfers, takes approximately 10 h 45 min.

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The distance between San Luis and Santiago is 401 km. The road distance is 620.3 km.

Get driving directions

The best way to get from San Luis to Santiago without a car is to bus which takes 10 h 45 min and costs $1300 - $1900.

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It takes approximately 10 h 45 min to get from San Luis to Santiago, including transfers.

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San Luis to Santiago bus services, operated by Cata International, depart from San Luis station.

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The best way to get from San Luis to Santiago is to bus which takes 10 h 45 min and costs $1300 - $1900. Alternatively, you can fly, which costs $9000 - $28000 and takes 8 h 25 min.

Mode details

There is no direct flight from San Luis Airport to Santiago Airport. The quickest flight takes 12 h 5 min and has one stopover.

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San Luis to Santiago bus services, operated by Tas-Choapa, arrive at Santiago station.

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Map of how to get from San Luis to Santiago.
Launch map view
  • Distance: 250.5 miles
  • Duration: 10 h 45 min

What companies run services between San Luis, Argentina and Santiago, Chile?

You can take a bus from San Luis to Santiago via Mendoza in around 10 h 45 min. Alternatively, Aerolíneas Argentinas, LATAM Chile and JetSMART fly from San Luis to Santiago 4 times a day.

Airlines
LATAM Chile
Website
latam.com
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery, Mendoza
Ave. Duration
7 h 41 min
When
Monday
Estimated price
$240 - $700
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery
Ave. Duration
12 h 19 min
When
Every day
Estimated price
$170 - $750
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery, Rio De Janeiro-Galeao
Ave. Duration
11 h 45 min
When
Monday, Tuesday, Thursday and Saturday
Estimated price
$300 - $1,100
Flights from Mendoza to Santiago
Ave. Duration
1 h
When
Every day
Estimated price
$150 - $480
JetSMART
Website
jetsmart.com
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery, Cordoba
Ave. Duration
11 h 21 min
When
Monday and Saturday
Estimated price
$240 - $700
Flights from Mendoza to Santiago
Ave. Duration
1 h
When
Monday, Tuesday, Friday and Saturday
Estimated price
$19 - $180
Aerolíneas Argentinas
Website
aerolineas.com.ar
Flights from San Luis to Santiago via Buenos Aires Jorge Newbery
Ave. Duration
12 h 25 min
When
Every day
Estimated price
$240 - $700
Sky Airline
Website
skyairline.com
Flights from Mendoza to Santiago
Ave. Duration
1 h
When
Every day
Estimated price
$55 - $330
Bus operators
Cata International
Phone
+54 800-122-2282
Email
atencionalcliente@catainternacional.com
Website
catainternacional.com
Bus from San Luis to Mendoza, Bus Terminal
Ave. Duration
3 h 45 min
Frequency
Every 4 hours
Estimated price
$14 - $21
Schedules at
catainternacional.com
Semi Bed
$14 - $20
Executive
$15 - $21
Bus from Mendoza to Santiago
Ave. Duration
7 h
Frequency
5 times a day
Estimated price
$17 - $28
Schedules at
catainternacional.com
Book at
catainternacional.com
Semi Bed
$17 - $25
Executive
$19 - $28
Andesmar
Phone
1 786 233 7639
Email
gestionesatc@andesmar.com.ar
Website
andesmar.com
Bus from San Luis to Mendoza
Ave. Duration
3 h 45 min
Frequency
5 times a day
Estimated price
$10 - $19
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$13 - $19
Executive
$10 - $15
Suite
$15 - $18
Bus from Mendoza to Santiago de Chile
Ave. Duration
8 h
Frequency
Once daily
Estimated price
$13 - $25
Schedules at
andesmar.com
Book at
andesmar.com
Economy
$14 - $21
Executive
$13 - $19
Suite
$19 - $22
Buses Lep
Phone
(+54) 351-246 6600, (+54) 0351-5696600, (+54) 0358-4219090
Email
expreso@buseslep.com.ar
Website
buseslep.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 44 min
Frequency
4 times a day
Estimated price
$8 - $14
Schedules at
buseslep.com.ar
Book at
buseslep.plataforma10.com.ar
Regular
$8 - $13
Premium
$11 - $14
San Juan Mar del Plata
Phone
[054] (0264) -4212405
Email
atencionalcliente@sanjuanmardelplata.com.ar
Website
sanjuanmardelplata.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 45 min
Frequency
3 times a day
Estimated price
$8 - $15
Schedules at
sanjuanmardelplata.com.ar
Book at
sanjuanmardelplata.centraldepasajes.com.ar
Regular
$8 - $12
Executive
$10 - $15
Central Argentino
Website
central-argentino.com
Bus from San Luis to Mendoza
Ave. Duration
3 h 57 min
Frequency
Twice daily
Estimated price
$6 - $10
Schedules at
central-argentino.com
Book at
centralargentino.plataforma10.com.ar
El Rapido Internacional
Phone
1-305-677-0535
Email
info@elrapidoint.com.ar
Website
elrapidoint.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 35 min
Frequency
Once daily
Estimated price
$7 - $13
Schedules at
elrapidoint.com.ar
Book at
elrapidoint.com.ar
Promo Semi Cama
$8 - $10
Semi Cama
$7 - $10
Cama
$11 - $13
Bus from San Luis to Mendoza
Ave. Duration
3 h 35 min
Frequency
Twice daily
Estimated price
$7 - $13
Schedules at
elrapidoint.com.ar
Book at
elrapidoint.com.ar
Promo Semi Cama
$8 - $10
Semi Cama
$7 - $10
Cama
$11 - $13
Viatac
Website
viatac.com.ar
Bus from San Luis to Mendoza
Ave. Duration
3 h 45 min
Frequency
Once daily
Estimated price
$8 - $14
Schedules at
viatac.com.ar
Book at
viatac.com.ar
Semi Bed
$8 - $12
Bed
$9 - $14
Tas-Choapa
Phone
+54 261 431-2140
Website
taschoapa.cl
Bus from Mendoza to Santiago
Ave. Duration
6 h
Frequency
Once daily
Estimated price
$30
Schedules at
taschoapa.cl
COITRAM
Phone
+54261 431-1999
Email
gestionesatc@andesmar.com.ar
Website
andesmar.com
Bus from Mendoza to Santiago
Ave. Duration
7 h
Frequency
Twice a week
Estimated price
$20
Schedules at
andesmar.com
Book at
andesmar.com
Chevallier
Phone
+54 0810-222-5216
Email
atencionalcliente@nuevachevallier.com
Website
nuevachevallier.com
Bus from San Luis to Mendoza
Ave. Duration
3 h 10 min
Frequency
Once daily
Estimated price
$10 - $19
Schedules at
nuevachevallier.com
Book at
nuevachevallier.com
Semi Bed
$10 - $16
Bed
$13 - $19

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More Questions & Answers

Yes, the driving distance between San Luis to Santiago is 620 km. It takes approximately 7 h 23 min to drive from San Luis to Santiago.

Get driving directions

JetSMART, LATAM Chile and Aerolíneas Argentinas offer flights from San Luis Airport to Santiago Airport.

Search flights

There are 2144+ hotels available in Santiago. Prices start at $44 USD per night.

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The best way to get from San Luis to San Luis Airport is to taxi which takes 4 min and costs $60 - $75.

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