Amtrak operates a train from San Diego to Tustin every 2 hours. Tickets cost $29 - $65 and the journey takes 1 h 56 min. Alternatively, Greyhound USA operates a bus from San Diego to Tustin hourly. Tickets cost $15 - $35 and the journey takes 2 h 5 min. Amtrak also services this route once daily.
From San Diego Santa Fe Depot Amtrak train to Santa Ana Regional Transportation Center Amtrak. 1 h 56 min $44. From San Diego, CA bus to Santa Ana, CA. 2 h 5 min $27. From San Diego drive to Tustin. 1 h 30 min $10.