There are 6 ways to get from San Diego to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5 h 18 min

  1. SAN - STL

$184 - $404

5 alternative options

Bus  •  41 h 30 min

  1. 7000 / ...
  2. 1684 / ...

$187 - $468

Train via Kansas City Amtrak  •  44 h 33 min

$300 - $895

Bus via Blythe, Ca  •  2 days 9 h

  1. Tijuana Airport-Matamoros / ...
  2. 1364 / ...

$205 - $469

Train  •  2 days 11 h

  1. Pacific Surfliner
  2. Texas Eagle

$333 - $974

Drive  •  28 h 48 min

  1. 1859.3 miles

$180 - $270

What companies run services between San Diego, CA, USA and St. Louis, MO, USA?

Southwest Airlines, Alaska Airlines, Inc. and three other airlines fly from San Diego to St. Louis hourly. Alternatively, you can take a bus from San Diego to St. Louis via San Bernardino, Ca in around 41 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from San Diego to St. Louis
Ave. Duration
3 h 29 min
When
Every day
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Denver
Ave. Duration
5 h 5 min
When
Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Las Vegas
Ave. Duration
5 h 30 min
When
Monday to Friday
Estimated price
$490 - $950
United Airlines
Website
united.com
Flights from San Diego to St. Louis via Denver
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$470 - $1,000
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from San Diego to St. Louis
Ave. Duration
3 h 32 min
When
Every day
Estimated price
$480 - $1,200
American Airlines
Website
aa.com
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$400 - $1,000
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from San Diego Santa Fe Depot Amtrak to Fullerton Transportation Center
Ave. Duration
2 h 14 min
Frequency
Every 2 hours
Estimated price
$30 - $65
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$50 - $80
Business Coach Seat
$45 - $65
Room
$160 - $220
Train from Fullerton Transportation Center to Kansas City Amtrak
Ave. Duration
34 h 39 min
Frequency
Twice daily
Estimated price
$220 - $700
Website
amtrak.com
Coach Seat
$220 - $330
Flexi Coach Seat
$390 - $600
Business Coach Seat
$470 - $700
Room
$850 - $1,200
Train from Kansas City Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
5 h 40 min
Frequency
4 times a day
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$85 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from San Diego Santa Fe Depot Amtrak to Los Angeles Union Station Amtrak
Ave. Duration
2 h 59 min
Frequency
Every 2 hours
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Los Angeles Union Station Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
2 days 7 h
Frequency
3 times a week
Estimated price
$300 - $900
Website
amtrak.com
Coach Seat
$300 - $440
Flexi Coach Seat
$500 - $750
Business Coach Seat
$600 - $900
Room
$1,100 - $1,600
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Diego, Ca to San Bernardino, Ca
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$30 - $40
Bus from San Bernardino, Ca to St Louis, Mo
Ave. Duration
38 h 15 min
Frequency
Hourly
Estimated price
$170 - $430
Website
greyhound.com
Economy
$170 - $280
Flexible
$330 - $430
Bus from Blythe, Ca to St Louis, Mo
Ave. Duration
38 h 19 min
Frequency
Hourly
Estimated price
$150 - $390
Website
greyhound.com
Economy
$150 - $250
Flexible
$290 - $390
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Diego to Blythe
Ave. Duration
18 h 40 min
Frequency
Twice daily
Estimated price
$50 - $80
Schedules at
greyhound.com.mx

Want to know more about travelling around United States

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Questions & Answers

The distance between San Diego and St. Louis is 2513 km. The road distance is 2975 km.

The cheapest way to get from San Diego to St. Louis is to drive which costs $180 - $270 and takes 28 h 48 min.

The quickest way to get from San Diego to St. Louis is to fly which takes 5 h 18 min and costs $180 - $410.

No, there is no direct train from San Diego to St. Louis. However, there are services departing from San Diego Santa Fe Depot Amtrak and arriving at St. Louis Gateway Station Amtrak via Fullerton Transportation Center and Kansas City Amtrak. The journey, including transfers, takes approximately 44 h 33 min.

No, there is no direct bus from San Diego to St. Louis. However, there are services departing from San Diego, Ca and arriving at St Louis, Mo via San Bernardino, Ca. The journey, including transfers, takes approximately 41 h 30 min.

It takes approximately 5 h 18 min to get from San Diego to St. Louis, including transfers.