There are 6 ways to get from San Diego to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5 h 15 min

  1. Fly from San Diego (SAN) to St. Louis (STL) SAN - STL

$185 - $406

5 alternative options

Bus  •  41 h 30 min

  1. Take the bus from San Diego, Ca to San Bernardino, Ca 7000 / ...
  2. Take the bus from San Bernardino, Ca to St Louis, Mo 1684 / ...

$187 - $468

Train via Kansas City Amtrak  •  44 h 12 min

  1. Take the train from San Diego Santa Fe Depot to Fullerton Transportation Center
  2. Take the train from Fullerton Transportation Center to Kansas City Amtrak
  3. Take the train from Kansas City Amtrak to St. Louis Gateway Station

$300 - $895

Bus via Blythe, Ca  •  46 h 54 min

  1. Take the bus from San Diego to Blythe Tijuana-Reynosa / ...
  2. Take the bus from Blythe, Ca to St Louis, Mo 1364 / ...

$206 - $471

Train  •  2 days 11 h

  1. Take the train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak Pacific Surfliner
  2. Take the train from Los Angeles Union Station Amtrak to St. Louis Gateway Station Texas Eagle

$333 - $974

Drive  •  28 h 48 min

  1. Drive from San Diego to St. Louis 1859.3 miles

$180 - $270

Questions & Answers

The cheapest way to get from San Diego to St. Louis is to drive which costs $180 - $270 and takes 28 h 48 min.

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The quickest way to get from San Diego to St. Louis is to fly which costs $180 - $410 and takes 5 h 15 min.

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No, there is no direct bus from San Diego to St. Louis. However, there are services departing from San Diego, Ca and arriving at St Louis, Mo via San Bernardino, Ca. The journey, including transfers, takes approximately 41 h 30 min.

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No, there is no direct train from San Diego to St. Louis station. However, there are services departing from San Diego Santa Fe Depot and arriving at St. Louis Gateway Station via Fullerton Transportation Center and Kansas City Amtrak. The journey, including transfers, takes approximately 44 h 12 min.

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The distance between San Diego and St. Louis is 1570 miles. The road distance is 1859.3 miles.

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The best way to get from San Diego to St. Louis without a car is to bus which takes 41 h 30 min and costs $180 - $470.

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It takes approximately 5 h 15 min to get from San Diego to St. Louis, including transfers.

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San Diego to St. Louis bus services, operated by Greyhound USA, depart from San Diego, Ca station.

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San Diego to St. Louis train services, operated by Amtrak, depart from San Diego Santa Fe Depot station.

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The best way to get from San Diego to St. Louis is to fly which takes 5 h 15 min and costs $180 - $410. Alternatively, you can bus, which costs $180 - $470 and takes 41 h 30 min, you could also train, which costs $300 - $900 and takes 44 h 12 min.

Mode details

Map of how to get from San Diego to St. Louis.
Launch map view
  • Distance: 1570.5 miles
  • Duration: 5 h 15 min

What companies run services between San Diego, CA, USA and St. Louis, MO, USA?

Southwest Airlines, Alaska Airlines, Inc. and three other airlines fly from San Diego to St. Louis hourly. Alternatively, you can take a bus from San Diego to St. Louis via San Bernardino, Ca in around 41 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from San Diego to St. Louis
Ave. Duration
3 h 27 min
When
Every day
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
4 h 55 min
When
Saturday and Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Las Vegas
Ave. Duration
5 h 7 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Denver
Ave. Duration
5 h 13 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Dallas
Ave. Duration
5 h 15 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Kansas City
Ave. Duration
5 h 10 min
When
Monday to Friday
Estimated price
$490 - $950
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from San Diego to St. Louis
Ave. Duration
3 h 40 min
When
Every day
Estimated price
$480 - $1,200
Flights from San Diego to St. Louis via Los Angeles
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$400 - $1,000
United Airlines
Website
united.com
Flights from San Diego to St. Louis via Denver
Ave. Duration
5 h 15 min
When
Every day
Estimated price
$470 - $1,000
American Airlines
Website
aa.com
Flights from San Diego to St. Louis via Los Angeles
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$400 - $1,000
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
5 h 21 min
When
Every day
Estimated price
$400 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from San Diego Santa Fe Depot to Fullerton Transportation Center
Ave. Duration
2 h 14 min
Frequency
Every 2 hours
Estimated price
$30 - $65
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$50 - $80
Business Coach Seat
$45 - $65
Room
$160 - $220
Train from Fullerton Transportation Center to Kansas City Amtrak
Ave. Duration
34 h 18 min
Frequency
Twice daily
Estimated price
$220 - $700
Website
amtrak.com
Coach Seat
$220 - $330
Flexi Coach Seat
$390 - $600
Business Coach Seat
$470 - $700
Room
$850 - $1,200
Train from Kansas City Amtrak to St. Louis Gateway Station
Ave. Duration
5 h 40 min
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$85 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak
Ave. Duration
2 h 59 min
Frequency
Every 2 hours
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Los Angeles Union Station Amtrak to St. Louis Gateway Station
Ave. Duration
2 days 7 h
Frequency
3 times a week
Estimated price
$300 - $900
Website
amtrak.com
Coach Seat
$300 - $440
Flexi Coach Seat
$500 - $750
Business Coach Seat
$600 - $900
Room
$1,100 - $1,600
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Diego, Ca to San Bernardino, Ca
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$30 - $40
Bus from San Bernardino, Ca to St Louis, Mo
Ave. Duration
38 h 15 min
Frequency
Hourly
Estimated price
$170 - $430
Website
greyhound.com
Economy
$170 - $280
Flexible
$330 - $430
Bus from Blythe, Ca to St Louis, Mo
Ave. Duration
38 h 19 min
Frequency
Hourly
Estimated price
$150 - $390
Website
greyhound.com
Economy
$150 - $250
Flexible
$290 - $390
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Diego to Blythe
Ave. Duration
8 h 5 min
Frequency
Twice daily
Estimated price
$55 - $85
Schedules at
greyhound.com.mx

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from San Diego Airport to St. Louis Airport is the direct flight which takes 3 h 25 min.

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San Diego to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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St. Louis is 2 h ahead of San Diego. It is currently 5:33 PM in San Diego and 7:33 PM in St. Louis.

San Diego to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between San Diego to St. Louis is 1859 miles. It takes approximately 28 h 48 min to drive from San Diego to St. Louis.

Get driving directions

Alaska Airlines, Inc., United Airlines, American Airlines and Southwest Airlines offer flights from San Diego Airport to St. Louis Airport.

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Book your San Diego to St. Louis train tickets online with Rome2rio.

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Book your San Diego to St. Louis bus tickets online with Greyhound and Greyhound.

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There are 185+ hotels available in St. Louis. Prices start at $71 USD per night.

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The best way to get from San Diego to San Diego Airport is to line 992 bus which takes 9 min and costs $2 - $3.

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