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There are 5 ways to get from San Diego to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5h 21m

  1. Fly from San Diego (SAN) to St. Louis (STL) SAN - STL

$185 - $406

4 alternative options

Train  •  44h 15m

  1. Take the train from San Diego Santa Fe Depot to Fullerton Amtrak Station
  2. Take the train from Fullerton Amtrak Station to Kansas City Union Station
  3. Take the train from Kansas City Union Station to St. Louis Gateway Station

$229 - $330

Bus  •  45h 39m

  1. Take the bus from San Diego, Ca to San Bernardino, Ca 7000 / ...
  2. Take the bus from San Bernardino, Ca to St Louis, Mo 1364 / ...

$197 - $274

Bus, train  •  2 days 8h

  1. Take the bus from San Diego to Yuma Amtrak Tijuana Airport-Ciudad Juárez / ...
  2. Take the train from Yuma Amtrak to St. Louis Gateway Station Texas Eagle

$235 - $343

Drive  •  28h 49m

  1. Drive from San Diego to St. Louis 1857.2 miles

$180 - $270

Questions & Answers

The cheapest way to get from San Diego to St. Louis is to drive which costs $180 - $270 and takes 28h 49m.

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The quickest way to get from San Diego to St. Louis is to fly which costs $180 - $410 and takes 5h 21m.

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No, there is no direct bus from San Diego to St. Louis. However, there are services departing from San Diego, Ca and arriving at St Louis, Mo via San Bernardino, Ca. The journey, including transfers, takes approximately 45h 39m.

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No, there is no direct train from San Diego to St. Louis station. However, there are services departing from San Diego Santa Fe Depot and arriving at St. Louis Gateway Station via Fullerton Amtrak Station and Kansas City Union Station. The journey, including transfers, takes approximately 44h 15m.

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The distance between San Diego and St. Louis is 1570 miles. The road distance is 1857.2 miles.

Get driving directions

The best way to get from San Diego to St. Louis without a car is to train which takes 44h 15m and costs $220 - $330.

More details

It takes approximately 5h 21m to get from San Diego to St. Louis, including transfers.

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San Diego to St. Louis bus services, operated by Greyhound USA, depart from San Diego, Ca station.

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San Diego to St. Louis train services, operated by Amtrak, depart from San Diego Santa Fe Depot station.

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The best way to get from San Diego to St. Louis is to fly which takes 5h 21m and costs $180 - $410. Alternatively, you can train, which costs $220 - $330 and takes 44h 15m, you could also bus, which costs $190 - $280 and takes 45h 39m.

Mode details

Map of how to get from San Diego to St. Louis.
Launch map view
  • Distance: 1570.5 miles
  • Duration: 5h 21m

What companies run services between San Diego, CA, USA and St. Louis, MO, USA?

Southwest Airlines, Alaska Airlines, Inc. and three other airlines fly from San Diego to St. Louis hourly. Alternatively, you can take a train from San Diego to St. Louis via Fullerton Amtrak Station and Kansas City Union Station in around 44h 15m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from San Diego to St. Louis
Ave. Duration
3h 31m
When
Every day
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
5h 10m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $950
Flights from San Diego to St. Louis via Las Vegas
Ave. Duration
5h 30m
When
Saturday and Sunday
Estimated price
$490 - $950
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from San Diego to St. Louis
Ave. Duration
3h 32m
When
Every day
Estimated price
$480 - $1,200
Flights from San Diego to St. Louis via Los Angeles
Ave. Duration
5h 27m
When
Every day
Estimated price
$400 - $1,000
American Airlines
Website
aa.com
Flights from San Diego to St. Louis via Phoenix
Ave. Duration
5h 22m
When
Every day
Estimated price
$400 - $1,000
Flights from San Diego to St. Louis via Los Angeles
Ave. Duration
5h 27m
When
Every day
Estimated price
$400 - $1,000
United Airlines
Website
united.com
Flights from San Diego to St. Louis via Denver
Ave. Duration
5h 40m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$470 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from San Diego Santa Fe Depot to Fullerton Amtrak Station
Ave. Duration
2h 17m
Frequency
Every 2 hours
Estimated price
$28 - $40
Website
amtrak.com
Coach Seat
$28 - $40
Premium
$190 - $260
Flexi Coach Seat
$40 - $65
Business Seat
$40 - $60
Train from Fullerton Amtrak Station to Kansas City Union Station
Ave. Duration
34h 18m
Frequency
Once daily
Estimated price
$160 - $230
Website
amtrak.com
Coach Seat
$160 - $230
Premium
$450 - $650
Flexi Coach Seat
$340 - $500
Business Seat
$370 - $550
Train from Kansas City Union Station to St. Louis Gateway Station
Ave. Duration
5h 40m
Frequency
Twice daily
Estimated price
$40 - $60
Website
amtrak.com
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Train from Yuma Amtrak to St. Louis Gateway Station
Ave. Duration
2 days 2h
Frequency
3 times a week
Estimated price
$190 - $280
Website
amtrak.com
Coach Seat
$190 - $280
Premium
$500 - $700
Flexi Coach Seat
$410 - $650
Business Seat
$450 - $650
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Diego, Ca to San Bernardino, Ca
Ave. Duration
2h 30m
Frequency
Twice daily
Estimated price
$17 - $24
Website
greyhound.com
Economy
$17 - $24
Flexible
$35 - $55
Bus from San Bernardino, Ca to St Louis, Mo
Ave. Duration
42h 9m
Frequency
Every 4 hours
Estimated price
$180 - $250
Website
greyhound.com
Economy
$180 - $250
Flexible
$250 - $360
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Diego to Yuma Amtrak
Ave. Duration
5h 15m
Frequency
Hourly
Estimated price
$45 - $65
Schedules at
greyhound.com.mx

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from San Diego Airport to St. Louis Airport is the direct flight which takes 3h 25m.

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San Diego to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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St. Louis is 2h ahead of San Diego. It is currently 1:56 AM in San Diego and 3:56 AM in St. Louis.

San Diego to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between San Diego to St. Louis is 1857 miles. It takes approximately 28h 49m to drive from San Diego to St. Louis.

Get driving directions

Alaska Airlines, Inc., United Airlines, American Airlines and Southwest Airlines offer flights from San Diego Airport to St. Louis Airport.

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Book your San Diego to St. Louis train tickets online with Rome2rio.

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Book your San Diego to St. Louis bus tickets online with Greyhound and Greyhound.

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There are 250+ hotels available in St. Louis. Prices start at $72 USD per night.

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The best way to get from San Diego to San Diego Airport is to line 992 bus which takes 15m and costs $2 - $3.

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