There are 7 ways to get from San Diego to Santa Clara by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to San Jose  •  2 h 51 min

  1. SAN - SJC

$79 - $334

Cheapest option

Bus Tufesa  •  13 h 52 min

  1. Tufesa
  2. Tufesa

$33 - $87

5 alternative options

Fly to San Francisco, Caltrain  •  4 h 39 min

  1. SAN - SFO

$82 - $328

Fly to Oakland, train  •  4 h 40 min

  1. SAN - OAK

$111 - $404

Bus Greyhound USA  •  10 h 2 min

  1. 9486 / ...
  2. 6860 / ...

$55 - $160

Train  •  14 h 15 min

  1. Pacific Surfliner
  2. Coast Starlight

$100 - $284

Drive  •  7 h 52 min

  1. 467.9 miles

$45 - $70

What companies run services between San Diego, CA, USA and Santa Clara, CA, USA?

Southwest Airlines, Alaska Airlines, Inc. and American Airlines fly from San Diego to Santa Clara hourly. Alternatively, you can take a bus from San Diego to Santa Clara via Los Angeles, Ca, San Jose, Ca, and San Jose Diridon Caltrain in around 10 h 2 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from San Diego to San Jose
Ave. Duration
1 h 22 min
When
Every day
Estimated price
$140 - $650
Flights from San Diego to San Francisco
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$150 - $650
Flights from San Diego to Oakland
Ave. Duration
1 h 29 min
When
Every day
Estimated price
$150 - $700
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from San Diego to San Jose
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$80 - $500
Flights from San Diego to San Francisco
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$130 - $550
United Airlines
Website
united.com
Flights from San Diego to San Francisco
Ave. Duration
1 h 36 min
When
Every day
Estimated price
$110 - $550
Train operators
Caltrain
Website
caltrain.com
Train from Millbrae Caltrain to Santa Clara Caltrain
Ave. Duration
1 h 3 min
Frequency
Every 30 minutes
Estimated price
$6 - $9
Schedules at
caltrain.com
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Oakland Coliseum Station Amtrak to Santa Clara Amtrak
Ave. Duration
51 min
Frequency
Every 4 hours
Estimated price
$22 - $45
Website
amtrak.com
Coach Seat
$22 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190
Train from San Diego Santa Fe Depot Amtrak to Los Angeles Union Station Amtrak
Ave. Duration
2 h 59 min
Frequency
Every 2 hours
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Los Angeles Union Station Amtrak to San Jose Diridon Station Amtrak
Ave. Duration
10 h 1 min
Frequency
Once daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$290 - $400
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Diego, Ca to Los Angeles, Ca
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$17 - $40
Website
greyhound.com
Economy
$17 - $27
Flexible
$30 - $40
Bus from Los Angeles, Ca to San Jose, Ca
Ave. Duration
6 h 45 min
Frequency
Hourly
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $90
Tufesa
Phone
016444102444
Website
tufesa.com.mx
Bus from San Diego, CA to Anaheim
Ave. Duration
2 h 39 min
Frequency
Twice daily
Estimated price
$9 - $20
Schedules at
tufesa.com.mx
Book at
gotobus.com
Plus
$9 - $13
Platinum
$14 - $18
Ejecutivo
$14 - $20
Bus from Anaheim to San Jose, CA
Ave. Duration
9 h 25 min
Frequency
Once daily
Estimated price
$22 - $65
Schedules at
tufesa.com.mx
Book at
gotobus.com
Plus
$22 - $35
Platinum
$30 - $45
Ejecutivo
$35 - $55

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Questions & Answers

The distance between San Diego and Santa Clara is 675 km. The road distance is 749 km.

The cheapest way to get from San Diego to Santa Clara is to drive which costs $45 - $70 and takes 7 h 52 min.

The quickest way to get from San Diego to Santa Clara is to fly which takes 2 h 51 min and costs $75 - $340.

No, there is no direct train from San Diego to Santa Clara. However, there are services departing from San Diego Santa Fe Depot Amtrak and arriving at Santa Clara Caltrain via Los Angeles Union Station Amtrak and San Jose Diridon Caltrain. The journey, including transfers, takes approximately 14 h 15 min.

No, there is no direct bus from San Diego to Santa Clara. However, there are services departing from San Diego, CA and arriving at Santa Clara Caltrain Station via Anaheim and King & Story. The journey, including transfers, takes approximately 13 h 52 min.

It takes approximately 2 h 51 min to get from San Diego to Santa Clara, including transfers.