There are 8 ways to get from San Diego to Santa Clara by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to San Jose  •  2 h 46 min

  1. Fly from San Diego (SAN) to San Jose (SJC) SAN - SJC

$79 - $334

Cheapest option

Bus Flixbus USA  •  11 h 29 min

  1. Take the bus from San Diego Mission Valley to San Jose FlixBus

$22 - $36

6 alternative options

Fly to San Francisco, Caltrain  •  4 h 16 min

  1. Fly from San Diego (SAN) to San Francisco (SFO) SAN - SFO
  2. Take the Caltrain from Millbrae Caltrain to Santa Clara Caltrain

$81 - $324

Fly to Oakland, train  •  4 h 31 min

  1. Fly from San Diego (SAN) to Oakland (OAK) SAN - OAK
  2. Take the train from Oakland Coliseum Station Amtrak to Santa Clara Amtrak

$111 - $404

Bus Greyhound USA  •  10 h 2 min

  1. Take the bus from San Diego, Ca to Los Angeles, Ca 9486 / ...
  2. Take the bus from Los Angeles, Ca to San Jose, Ca 6860 / ...

$56 - $160

Train, bus  •  10 h 45 min

  1. Take the train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak Pacific Surfliner
  2. Take the bus from Los Angeles, CA to San Jose, CA

$66 - $149

Train  •  14 h 15 min

  1. Take the train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak Pacific Surfliner
  2. Take the train from Los Angeles Union Station Amtrak to San Jose Diridon Station Coast Starlight

$101 - $284

Drive  •  7 h 52 min

  1. Drive from San Diego to Santa Clara 467.9 miles

$45 - $70

Questions & Answers

The cheapest way to get from San Diego to Santa Clara is to bus which costs $22 - $40 and takes 11 h 29 min.

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The quickest way to get from San Diego to Santa Clara is to fly which costs $75 - $340 and takes 2 h 46 min.

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No, there is no direct bus from San Diego to Santa Clara. However, there are services departing from 4th Av & Broadway and arriving at El Camino & Lincoln via Fashion Valley Transit Center, San Diego Mission Valley and Eastridge Transit Center. The journey, including transfers, takes approximately 11 h 29 min.

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No, there is no direct train from San Diego to Santa Clara. However, there are services departing from San Diego Santa Fe Depot and arriving at Santa Clara Caltrain via Los Angeles Union Station Amtrak and San Jose Diridon Caltrain. The journey, including transfers, takes approximately 14 h 15 min.

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The distance between San Diego and Santa Clara is 422 miles. The road distance is 467.9 miles.

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The best way to get from San Diego to Santa Clara without a car is to bus which takes 10 h 2 min and costs $55 - $160.

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It takes approximately 2 h 46 min to get from San Diego to Santa Clara, including transfers.

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San Diego to Santa Clara bus services, operated by Flixbus USA, depart from San Diego Mission Valley station.

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San Diego to Santa Clara train services, operated by Amtrak, depart from San Diego Santa Fe Depot station.

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The best way to get from San Diego to Santa Clara is to fly which takes 2 h 46 min and costs $75 - $340. Alternatively, you can bus, which costs $55 - $160 and takes 10 h 2 min, you could also train, which costs $100 - $290 and takes 14 h 15 min.

Mode details

Map of how to get from San Diego to Santa Clara.
Launch map view
  • Distance: 422.1 miles
  • Duration: 2 h 46 min

What companies run services between San Diego, CA, USA and Santa Clara, CA, USA?

Southwest Airlines, Alaska Airlines, Inc. and American Airlines fly from San Diego to Santa Clara hourly. Alternatively, you can take a bus from San Diego to Santa Clara via Los Angeles, Ca, San Jose, Ca, and San Jose Diridon Caltrain in around 10 h 2 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from San Diego to San Jose
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$140 - $650
Flights from San Diego to San Francisco
Ave. Duration
1 h 32 min
When
Every day
Estimated price
$150 - $650
Flights from San Diego to Oakland
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$150 - $700
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from San Diego to San Jose
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$80 - $500
Flights from San Diego to San Jose via Los Angeles
Ave. Duration
3 h 18 min
When
Every day
Estimated price
$80 - $500
Flights from San Diego to San Francisco
Ave. Duration
1 h 35 min
When
Every day
Estimated price
$130 - $550
United Airlines
Website
united.com
Flights from San Diego to San Francisco
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$110 - $550
Train operators
Caltrain
Phone
+1 650-508-6200
Website
caltrain.com
Train from Millbrae Caltrain to Santa Clara Caltrain
Ave. Duration
1 h 3 min
Frequency
Every 30 minutes
Estimated price
$7 - $9
Schedules at
caltrain.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Oakland Coliseum Station Amtrak to Santa Clara Amtrak
Ave. Duration
51 min
Frequency
Every 4 hours
Estimated price
$22 - $45
Website
amtrak.com
Coach Seat
$22 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190
Train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak
Ave. Duration
2 h 59 min
Frequency
Every 2 hours
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Los Angeles Union Station Amtrak to San Jose Diridon Station
Ave. Duration
10 h 1 min
Frequency
Once daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$290 - $400
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Diego, Ca to Los Angeles, Ca
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$17 - $40
Website
greyhound.com
Economy
$17 - $27
Flexible
$30 - $40
Bus from Los Angeles, Ca to San Jose, Ca
Ave. Duration
6 h 45 min
Frequency
Hourly
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $90
Flixbus USA
Phone
(855) 626-8585
Website
flixbus.com
Bus from San Diego Mission Valley to San Jose
Ave. Duration
8 h 35 min
Frequency
Once daily
Estimated price
$16 - $28
Schedules at
flixbus.com

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More Questions & Answers

The quickest flight from San Diego Airport to San Jose Airport is the direct flight which takes 1 h 15 min.

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San Diego to Santa Clara bus services, operated by Flixbus USA, arrive at San Jose station.

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San Diego to Santa Clara train services, operated by Amtrak, arrive at San Jose Diridon Station.

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Yes, the driving distance between San Diego to Santa Clara is 468 miles. It takes approximately 7 h 52 min to drive from San Diego to Santa Clara.

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American Airlines, Alaska Airlines, Inc. and Southwest Airlines offer flights from San Diego Airport to San Jose Airport.

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There are 414+ hotels available in Santa Clara. Prices start at $104 USD per night.

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The best way to get from San Diego to San Diego Airport is to line 992 bus which takes 9 min and costs $2 - $3.

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