• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 6 ways to get from San Diego to Florida Keys by plane, shuttle, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Key West  •  10 h 4 min

  1. Fly from San Diego (SAN) to Key West (EYW) SAN - EYW

$374 - $1,406

Cheapest option

Fly to Miami, shuttle  •  11 h 18 min

  1. Fly from San Diego (SAN) to Miami (MIA) SAN - MIA
  2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL

$214 - $802

4 alternative options

Fly to Fort Lauderdale, shuttle  •  11 h 54 min

  1. Fly from San Diego (SAN) to Fort Lauderdale (FLL) SAN - FLL
  2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL

$214 - $606

Bus  •  3 days 0 h

  1. Take the bus from San Diego to San Antonio
  2. Take the bus from San Antonio, Tx to Houston, Tx
  3. Take the bus from Houston, Tx to Miami, Fl
  4. Take the bus from Miami, Fl to Big Pine Key

$267 - $583

Bus, train  •  3 days 5 h

  1. Take the bus from San Diego to Yuma
  2. Take the train from Yuma Amtrak to New Orleans Union Passenger Terminal
  3. Take the bus from New Orleans, La to Miami, Fl
  4. Take the bus from Miami, Fl to Big Pine Key

$361 - $982

Drive  •  45 h 51 min

  1. Drive from San Diego to Florida Keys 2813 miles

$270 - $400

Questions & Answers

The cheapest way to get from San Diego to Florida Keys is to fly and shuttle which costs $210 - $650 and takes 11 h 54 min.

More details

The quickest way to get from San Diego to Florida Keys is to fly which costs $370 - $1,500 and takes 10 h 4 min.

More details

No, there is no direct bus from San Diego to Florida Keys. However, there are services departing from San Diego and arriving at Sugarloaf Key, FL via San Antonio, Tx, Houston, Tx, Miami, Fl and Lower Keys Shuttle. The journey, including transfers, takes approximately 3 days 0 h.

More details

The distance between San Diego and Florida Keys is 2230 miles. The road distance is 2813 miles.

Get driving directions

The best way to get from San Diego to Florida Keys without a car is to bus which takes 3 days 0 h and costs $260 - $600.

More details

It takes approximately 10 h 4 min to get from San Diego to Florida Keys, including transfers.

More details

San Diego to Florida Keys bus services, operated by Greyhound Mexico, depart from San Diego station.

More details

The best way to get from San Diego to Florida Keys is to fly which takes 10 h 4 min and costs $370 - $1,500. Alternatively, you can bus, which costs $260 - $600 and takes 3 days 0 h.

Mode details

There is no direct flight from San Diego Airport to Key West Airport. The quickest flight takes 7 h 8 min and has one stopover.

Search flights

San Diego to Florida Keys bus services, operated by Greyhound USA, arrive at Big Pine Key station.

More details

Map of how to get from San Diego to Florida Keys.
Launch map view
  • Distance: 2230.3 miles
  • Duration: 10 h 4 min

What companies run services between San Diego, CA, USA and Florida Keys, FL, USA?

Delta, American Airlines and United Airlines fly from San Diego to Florida Keys hourly. Alternatively, you can take a bus from San Diego to Florida Keys via San Antonio, San Antonio, Tx, Houston, Tx, Miami, Fl, Big Pine Key, Lower Keys Shuttle, and Sugarloaf Key, FL in around 3 days 0 h.

Airlines
American Airlines
Website
aa.com
Flights from San Diego to Key West via Dallas/Ft.Worth
Ave. Duration
7 h 17 min
When
Every day
Estimated price
$370 - $1,400
Flights from San Diego to Key West via Charlotte
Ave. Duration
9 h 17 min
When
Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$430 - $1,500
Flights from San Diego to Key West via Miami
Ave. Duration
9 h 57 min
When
Every day
Estimated price
$390 - $1,400
Flights from San Diego to Key West via Chicago O'Hare
Ave. Duration
11 h 15 min
When
Friday
Estimated price
$440 - $1,500
Flights from San Diego to Key West via Philadelphia
Ave. Duration
11 h 51 min
When
Friday
Estimated price
$490 - $1,600
Flights from San Diego to Key West via Phoenix, Miami
Ave. Duration
9 h 22 min
When
Every day
Estimated price
$390 - $1,400
Flights from San Diego to Key West via Los Angeles, Miami
Ave. Duration
9 h 22 min
When
Every day
Estimated price
$400 - $1,500
Flights from San Diego to Miami
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$170 - $900
Flights from San Diego to Miami via Dallas/Ft.Worth
Ave. Duration
6 h 53 min
When
Every day
Estimated price
$170 - $900
Flights from San Diego to Miami via Phoenix
Ave. Duration
6 h 56 min
When
Every day
Estimated price
$170 - $900
Flights from San Diego to Miami via Los Angeles
Ave. Duration
6 h 59 min
When
Every day
Estimated price
$170 - $900
Flights from San Diego to Fort Lauderdale via Dallas/Ft.Worth
Ave. Duration
6 h 37 min
When
Every day
Estimated price
$180 - $800
Southwest Airlines
Website
southwest.com
Flights from San Diego to Fort Lauderdale via Tampa
Ave. Duration
6 h 10 min
When
Wednesday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Phoenix
Ave. Duration
6 h 20 min
When
Wednesday, Thursday and Friday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Houston Hobby Apt
Ave. Duration
6 h 15 min
When
Wednesday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Austin
Ave. Duration
6 h 20 min
When
Monday to Friday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Dallas
Ave. Duration
6 h 25 min
When
Wednesday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Orlando
Ave. Duration
6 h 25 min
When
Saturday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via New Orleans
Ave. Duration
6 h 32 min
When
Monday to Friday
Estimated price
$240 - $900
Flights from San Diego to Fort Lauderdale via Las Vegas
Ave. Duration
6 h 45 min
When
Wednesday
Estimated price
$240 - $900
Delta
Website
delta.com
Flights from San Diego to Key West via Atlanta
Ave. Duration
8 h 24 min
When
Every day
Estimated price
$370 - $1,500
Flights from San Diego to Key West via Las Vegas, Atlanta
Ave. Duration
9 h 45 min
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$380 - $1,500
Flights from San Diego to Miami via Atlanta
Ave. Duration
7 h
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$180 - $1,300
United Airlines
Website
united.com
Flights from San Diego to Key West via Chicago O'Hare
Ave. Duration
11 h 56 min
When
Friday
Estimated price
$430 - $1,700
Flights from San Diego to Key West via Newark
Ave. Duration
12 h 7 min
When
Every day
Estimated price
$480 - $1,900
Flights from San Diego to Miami via Houston
Ave. Duration
6 h 36 min
When
Every day
Estimated price
$180 - $1,200
Flights from San Diego to Miami via Denver
Ave. Duration
6 h 51 min
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$180 - $1,200
Flights from San Diego to Fort Lauderdale via Houston
Ave. Duration
6 h 39 min
When
Every day
Estimated price
$140 - $750
JetBlue Airways
Website
jetblue.com
Flights from San Diego to Fort Lauderdale
Ave. Duration
4 h 45 min
When
Every day
Estimated price
$150 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Yuma Amtrak to New Orleans Union Passenger Terminal
Ave. Duration
41 h 53 min
Frequency
3 times a week
Estimated price
$210 - $650
Website
amtrak.com
Coach Seat
$210 - $320
Flexi Coach Seat
$380 - $550
Business Coach Seat
$460 - $650
Room
$800 - $1,200
Bus operators
Keys Shuttle
Phone
+1 (888) 765-9997 | (305) 289-9997
Website
keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
Ave. Duration
3 h
Frequency
5 times a day
Estimated price
$80 - $95
Schedules at
keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
Ave. Duration
3 h 30 min
Frequency
5 times a day
Estimated price
$90 - $110
Schedules at
keysshuttle.com
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Diego to San Antonio
Ave. Duration
30 h
Frequency
Every 2 hours
Estimated price
$110 - $180
Schedules at
greyhound.com.mx
Bus from San Diego to Yuma
Ave. Duration
3 h 40 min
Frequency
Every 4 hours
Estimated price
$45 - $65
Schedules at
greyhound.com.mx
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Antonio, Tx to Houston, Tx
Ave. Duration
3 h 15 min
Frequency
5 times a day
Estimated price
$24 - $60
Website
greyhound.com
Economy
$24 - $40
Flexible
$45 - $60
Bus from Houston, Tx to Miami, Fl
Ave. Duration
31 h 14 min
Frequency
4 times a day
Estimated price
$110 - $300
Website
greyhound.com
Economy
$110 - $200
Flexible
$220 - $300
Bus from Miami, Fl to Big Pine Key
Ave. Duration
3 h 35 min
Frequency
Twice daily
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$30 - $45
Bus from New Orleans, La to Miami, Fl
Ave. Duration
23 h 45 min
Frequency
4 times a day
Estimated price
$85 - $220
Website
greyhound.com
Economy
$85 - $150
Flexible
$160 - $220

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Florida Keys is 3 h ahead of San Diego. It is currently 7:22 AM in San Diego and 10:22 AM in Florida Keys.

Yes, the driving distance between San Diego to Florida Keys is 2813 miles. It takes approximately 45 h 51 min to drive from San Diego to Florida Keys.

Get driving directions

United Airlines, Delta and American Airlines offer flights from San Diego Airport to Key West Airport.

Search flights

There are 21+ hotels available in Florida Keys. Prices start at $100 USD per night.

More details

The best way to get from San Diego to San Diego Airport is to line 992 bus which takes 9 min and costs $2 - $3.

More details