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There are 6 ways to get from Salar de Uyuni to Santa Cruz de la Sierra by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  2 h 21 min

  1. Fly from Uyuni (UYU) to Santa Cruz (VVI) UYU - VVI

$161 - $340

Cheapest option

Bus Linea Sindical Flota Villa Imperial  •  20 h 29 min

  1. Take the bus from Uyuni to Potosi
  2. Take the bus from Potosí to Santa Cruz de la Sierra

$66 - $78

4 alternative options

Bus Trans Salvador  •  19 h 29 min

  1. Take the bus from Uyuni to Oruro
  2. Take the bus from Oruro to Santa Cruz de la Sierra

$74 - $126

Bus Trans 6 de Octubre  •  21 h 59 min

  1. Take the bus from Uyuni to Sucre
  2. Take the bus from Sucre to Santa Cruz

$72 - $89

Train, bus  •  23 h 29 min

  1. Take the train from Uyuní to Oruro Expreso del Sur / ...
  2. Take the bus from Oruro to Santa Cruz de la Sierra

$69 - $133

Drive  •  15 h 16 min

  1. Drive from Salar de Uyuni to Santa Cruz de la Sierra 631.1 miles

$45 - $70

Questions & Answers

The cheapest way to get from Salar de Uyuni to Santa Cruz de la Sierra is to drive which costs $45 - $70 and takes 15 h 16 min.

More details

The quickest way to get from Salar de Uyuni to Santa Cruz de la Sierra is to fly which costs $160 - $340 and takes 2 h 21 min.

More details

The distance between Salar de Uyuni and Santa Cruz de la Sierra is 488 km. The road distance is 1009.8 km.

Get driving directions

The best way to get from Salar de Uyuni to Santa Cruz de la Sierra without a car is to bus which takes 19 h 29 min and costs $70 - $130.

More details

It takes approximately 2 h 21 min to get from Salar de Uyuni to Santa Cruz de la Sierra, including transfers.

More details

The best way to get from Salar de Uyuni to Santa Cruz de la Sierra is to fly which takes 2 h 21 min and costs $160 - $340. Alternatively, you can bus, which costs $70 - $130 and takes 19 h 29 min.

Mode details

The quickest flight from Uyuni Airport to Santa Cruz Airport is the direct flight which takes 1 h 15 min.

Search flights

Yes, the driving distance between Salar de Uyuni to Santa Cruz de la Sierra is 1010 km. It takes approximately 15 h 16 min to drive from Salar de Uyuni to Santa Cruz de la Sierra.

Get driving directions

Amaszonas offers flights from Uyuni Airport to Santa Cruz Airport.

Search flights

There are 239+ hotels available in Santa Cruz de la Sierra. Prices start at $26 USD per night.

More details

Map of how to get from Salar de Uyuni to Santa Cruz de la Sierra.
Launch map view
  • Distance: 305.3 miles
  • Duration: 2 h 21 min

What companies run services between Salar de Uyuni, Bolivia and Santa Cruz de la Sierra, Bolivia?

Amaszonas flies from Salar de Uyuni to Santa Cruz de la Sierra once daily. Alternatively, you can take a bus from Salar de Uyuni to Santa Cruz de la Sierra via Uyuni and Oruro in around 19 h 29 min.

Airlines
Amaszonas
Website
amaszonas.com
Flights from Uyuni to Santa Cruz
Ave. Duration
1 h 15 min
When
Monday, Wednesday and Friday
Estimated price
$110 - $900
Flights from Uyuni to Santa Cruz via La Paz
Ave. Duration
2 h 40 min
When
Monday to Saturday
Estimated price
$110 - $900
Train operators
Empresa Ferroviaria Andina S.A
Phone
(+591-2) 2184555 / 4566
Website
fca.com.bo
Train from Uyuní to Oruro
Ave. Duration
7 h 6 min
Frequency
3 times a week
Estimated price
$4 - $19
Schedules at
ferroviaria-andina.com.bo
Book at
ticketsbolivia.com.bo
Wara Wara del Sur - Popular
$4 - $6
Wara Wara del Sur - Salon
$7 - $9
Expreso del Sur - Salon
$9 - $11
Wara Wara del Sur - Ejecutivo
$15 - $19
Bus operators
Trans Azul
Phone
+591 5254060
Website
facebook.com
Bus from Uyuni to Oruro
Ave. Duration
5 h
Frequency
Once a week
Estimated price
$5 - $7
Schedules at
ticketsbolivia.com.bo
Book at
ticketsbolivia.com.bo
Trans Salvador
Expreso 11 de Julio
Phone
+591 62459036
Website
facebook.com
Bus from Uyuni to Potosi
Ave. Duration
4 h
Frequency
Twice daily
Estimated price
$9
Schedules at
facebook.com
Book at
ticketsbolivia.com.bo
Linea Sindical Flota Villa Imperial
Phone
+(591)-2-6243373
Website
facebook.com
Bus from Potosí to Santa Cruz de la Sierra
Ave. Duration
15 h
Frequency
Twice daily
Estimated price
$15
Schedules at
potosy.com.bo
Autotransportes Tupiza
Phone
+591 68421233 Tupiza / 3 3311649 Santa Cruz / 2 6243044 Potosí
Website
facebook.com
Bus from Potosí to Santa Cruz de la Sierra
Ave. Duration
17 h
Frequency
Once daily
Estimated price
$13 - $17
Schedules at
facebook.com
Bus from Sucre to Santa Cruz de la Sierra - Terminal Bimodal
Ave. Duration
14 h
Frequency
Once daily
Estimated price
$10 - $13
Schedules at
facebook.com
Trans 6 de Octubre
Phone
+591 79576765
Bus from Uyuni to Sucre
Ave. Duration
7 h
Frequency
Once daily
Estimated price
$18
Schedules at
ticketsbolivia.com.bo
Book at
ticketsbolivia.com.bo
Bus from Sucre to Santa Cruz
Ave. Duration
13 h 30 min
Frequency
3 times a day
Estimated price
$19
Schedules at
ticketsbolivia.com.bo
Book at
ticketsbolivia.com.bo
Todo Turismo
Phone
+(591) 2228 7038
Email
atencionalcliente@todoturismosrl.com
Website
todoturismosrl.com
Bus from Uyuni to Sucre Bus Terminal
Ave. Duration
12 h 30 min
Frequency
Once daily
Schedules at
todoturismosrl.com
Book at
todoturismosrl.com
Trans Caminante SRL
Phone
+591 71162388 Santa Cruz / 4 6429385 Sucre
Website
facebook.com
Bus from Sucre to Santa Cruz - Terminal Bimodal
Ave. Duration
13 h 30 min
Frequency
Twice daily
Estimated price
$14
Schedules at
facebook.com
El Mexicano
Phone
+591 67640155
Website
facebook.com
Bus from Sucre to Santa Cruz - Terminal Bimodal
Ave. Duration
13 h
Frequency
Once daily
Estimated price
$15
Schedules at
facebook.com
Flota Bolivar
Phone
+591 2 2281973 La Paz / 4 4221819 Cochabamba / 3 3625458 Santa Cruz / 4 6453849 Sucre / 4 6830856 Yacuiba
Website
facebook.com
Bus from Sucre to Santa Cruz
Ave. Duration
13 h
Frequency
Once daily
Estimated price
$12 - $19
Schedules at
facebook.com

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More Questions & Answers

The best way to get from Salar de Uyuni to Uyuni Airport is to taxi which takes 34 min and costs $50 - $60.

More details