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How to get fromSaco to Buffaloby train, plane, bus (Amtrak, Greyhound, Flixbus), train (Amtrak), car or bus

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There are 8 ways to get from Saco to Buffalo by train, plane, bus (Amtrak, Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 39m
    $174–981

  2. Bus

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    15h 9m
    $78–196

  3. Train (Amtrak)

    1. Take the train from Saco Amtrak Station to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 15m
    $134–379

  4. Drive 494.2 mi

    1. Drive from Saco to Buffalocar car 494.2 mi
    10h 6m
    $91–131

  5. Fly Portland to Buffalo Niagara International Airport

    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    7h 56m
    $242–1,444

  6. Train to Boston Logan Airport, fly to Rochester, bus

    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 46m
    $255–747

  7. Fly Portland to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (ROC)plane plane PWM - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 51m
    $303–1,260

  8. Train, bus

    1. Take the train from Saco Amtrak Station to Bostontrain train
    2. Take the bus from Boston, MA - Dalton and Belvidere Street to New York, NY - W 42nd Street and 9th Avenuebus bus
    3. Take the bus from New York to Buffalobus bus
    16h 32m
    $105–409

Saco to Buffalo by train and subway (Amtrak)

Calendar7Weekly Services
Duration16h 15mAverage Duration
Ticket$134Cheapest Price
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Questions & Answers

What companies run services between Saco, ME, USA and Buffalo, NY, USA?

You can take a bus from Dyer Library to Buffalo via Portland Public Library, Portland, ME, Boston, MA - South Station, Boston, and Syracuse Bus Station in around 15h 9m. Alternatively, you can take a train from Saco Amtrak Station to Buffalo via Boston, North Station, Back Bay, Boston, and Buffalo Depew Station in around 16h 15m.

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