There are 7 ways to get from Saco to Buffalo by train, plane, bus (Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Boston Logan Airport, fly to Buffalo Niagara International Airport
best- Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
6h 24m$168–989Bus via Ithaca
cheapest- Take the bus from Dyer Library to St John Stbus 60
- Take the bus from City of Portland to Springfield Union Stationbus
- Take the bus from Springfield Union Station to Ithacabus
- Take the bus from Ithaca to Buffalobus
17h 39m$90–212Bus
- Take the bus from Portland, ME to Boston, MA - South Stationbus Portland / ...
- Take the bus from Boston to Buffalobus Greyhound US0171
14h 56m$100–201Train (Amtrak)
- Take the train from Saco Amtrak Station to Bostontrain Downeaster
- Take the train from Boston to Buffalo Depew Stationtrain Lake Shore Limited
16h 14m$169–427Drive 494.2 mi
- Drive from Saco to Buffalocar 494.2 mi
10h 6m$91–131Fly Portland to Buffalo Niagara International Airport
- Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane PWM - BUF
8h 7m$293–1,645Train to Boston Logan Airport, fly to Rochester, bus
- Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
7h 46m$290–857
Saco to Buffalo by bus
Questions & Answers
The cheapest way to get from Saco to Buffalo is to drive which costs $90 - $130 and takes 10h 6m.
The fastest way to get from Saco to Buffalo is to train and fly which takes 6h 24m and costs $160 - $1,000.
No, there is no direct bus from Saco to Buffalo. However, there are services departing from Dyer Library and arriving at Buffalo via Portland Public Library, Portland, ME and Boston. The journey, including transfers, takes approximately 14h 56m.
No, there is no direct train from Saco station to Buffalo. However, there are services departing from Saco Amtrak Station and arriving at Buffalo via North Station, Boston and Buffalo Depew Station. The journey, including transfers, takes approximately 16h 14m.
The distance between Saco and Buffalo is 509 miles. The road distance is 497.1 miles.
The best way to get from Saco to Buffalo without a car is to bus which takes 14h 56m and costs $100 - $210.
It takes approximately 6h 24m to get from Saco to Buffalo, including transfers.
Saco to Buffalo bus services, operated by Concord Coach Lines, depart from Portland, ME station.
Saco to Buffalo train services, operated by Amtrak, depart from Saco Amtrak Station.
The best way to get from Saco to Buffalo is to bus which takes 14h 56m and costs $100 - $210. Alternatively, you can train, which costs $160 - $430 and takes 16h 14m, you could also fly, which costs $290 - $1,700 and takes 8h 7m.
What companies run services between Saco, ME, USA and Buffalo, NY, USA?
You can take a bus from Dyer Library to Buffalo via Portland Public Library, Portland, ME, Boston, MA - South Station, and Boston in around 14h 56m. Alternatively, you can take a train from Saco Amtrak Station to Buffalo via Boston, North Station, Back Bay, Boston, and Buffalo Depew Station in around 16h 14m.
- Website
- aa.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $130–900
Flights from Portland to Buffalo Niagara International Airport via Philadelphia
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $300–1,700
Flights from Portland to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 5h 33m
- When
- Every day
- Estimated price
- $280–1,600
Flights from Portland to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 6h 10m
- When
- Every day
- Estimated price
- $340–1,800
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $70–460
Flights from Boston Logan Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $90–550
- Website
- delta.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 4h 1m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–950
Flights from Portland to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 6h 37m
- When
- Every day
- Estimated price
- $280–1,600
Flights from Portland to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 6h 44m
- When
- Every day
- Estimated price
- $280–1,600
Flights from Portland to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $380–2,000
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 3h 54m
- When
- Monday to Friday
- Estimated price
- $80–490
- Website
- southwest.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $180–1,100
Flights from Portland to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 5h 20m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $330–1,800
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 4h 5m
- When
- Tuesday and Wednesday
- Estimated price
- $100–600
- Website
- united.com
Flights from Portland to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $340–1,800
Flights from Portland to Buffalo Niagara International Airport via Newark
- Ave. Duration
- 7h 28m
- When
- Every day
- Estimated price
- $280–1,600
- Website
- jetblue.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $130–900
Flights from Portland to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 6h 36m
- When
- Every day
- Estimated price
- $280–1,600
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Saco Amtrak Station to Woburn Amtrak Station
- Ave. Duration
- 1h 49m
- Frequency
- Every 4 hours
- Estimated price
- $23–55
- Website
- https://www.amtrak.com/home.html
Train from Saco Amtrak Station to Boston
- Ave. Duration
- 2h 10m
- Frequency
- Every 4 hours
- Estimated price
- $27–60
- Website
- https://www.amtrak.com/home.html
Train from Boston to Buffalo Depew Station
- Ave. Duration
- 11h 32m
- Frequency
- Once daily
- Estimated price
- $130–290
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800 639 3317
- info@concordcoachlines.com
- Website
- concordcoachlines.com
Bus from Portland, ME to Boston, MA - South Station
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $23–30
- Website
- https://concordcoachlines.com
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Portland, ME to Boston, MA - South Station
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $21–45
- Website
- https://www.amtrak.com/home.html
- Adult
- $21–45
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Boston to Buffalo
- Ave. Duration
- 10h 5m
- Frequency
- Once daily
- Estimated price
- $75–150
- Website
- https://www.greyhound.com/
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $12–24
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- $9–16
- Schedules at
- flixbus.com
Bus from City of Portland to Springfield Union Station
- Ave. Duration
- 4h 6m
- Frequency
- Once daily
- Estimated price
- $25–45
- Schedules at
- flixbus.com
Bus from Springfield Union Station to Ithaca
- Ave. Duration
- 5h 44m
- Frequency
- 5 times a week
- Estimated price
- $35–65
- Schedules at
- flixbus.com
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Schedules at
- flixbus.com
- Phone
- 207 282 5408
- Website
- bsoobtransit.org
Bus from Dyer Library to St John St
- Ave. Duration
- 1h 9m
- Frequency
- Every 4 hours
- Estimated price
- $2
- Website
- https://bsoobtransit.org/
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $28–100
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $28–95
- Flexible
- $55–100
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More Questions & Answers
Saco to Buffalo bus services, operated by Concord Coach Lines, arrive at Boston, MA - South Station.
Saco to Buffalo train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between Saco to Buffalo is 497 miles. It takes approximately 10h 6m to drive from Saco to Buffalo.
Book your Saco to Buffalo train tickets online with Omio.
There are 573+ hotels available in Buffalo.













