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How to get fromSaco to Buffaloby train, plane, bus, train (Amtrak), car or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from Saco to Buffalo by train, plane, bus, train (Amtrak), car, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)planeBOS - BUF
    6h 38m
    $174–1,104

  2. Train, bus

    cheapest
    1. Take the train from Saco Amtrak Station to Bostontrain
    2. Take the bus from Boston, MA to Syracuse, NYbus
    3. Take the bus from Syracuse, NY to Buffalo, NYbus
    14h 40m
    $71–193

  3. Train (Amtrak)

    1. Take the train from Saco Amtrak Station to BostontrainDowneaster
    2. Take the train from Boston to Buffalo Depew StationtrainLake Shore Limited
    16h 15m
    $88–281

  4. Drive 494.2 mi

    1. Drive from Saco to Buffalocar494.2 mi
    10h 2m
    $91–131

  5. Fly Portland to Buffalo Niagara International Airport

    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)planePWM - BUF
    7h 45m
    $252–1,492

  6. Train to Boston Logan Airport, fly to Rochester, bus

    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)planeBOS - ROC
    3. Take the bus from Rochester, NY to Buffalo, NYbus
    8h 40m
    $194–659

  7. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus
    2. Take the bus from Boston to Syracuse Bus Stationbus
    3. Take the bus from Syracuse Bus Station to Buffalobus
    15h 10m
    $104–276

Saco to Buffalo by train, tram, and bus

Calendar2Weekly Services
Duration14h 40mAverage Duration
Ticket$71Cheapest Price
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Questions & Answers

What companies run services between Saco, ME, USA and Buffalo, NY, USA?

You can take a train from Saco Amtrak Station to Buffalo via Boston, North Station, Back Bay, Boston, and Buffalo Depew Station in around 16h 15m. Alternatively, American Airlines, Delta, and three other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly.

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