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How to get fromSaco to Buffaloby train, plane, bus (Amtrak, Greyhound), train (Amtrak), car, bus or bus (Flixbus)

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There are 7 ways to get from Saco to Buffalo by train, plane, bus (Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 24m
    $168–989
  2. Bus via Ithaca

    cheapest
    1. Take the bus from Dyer Library to St John Stbus bus 60
    2. Take the bus from City of Portland to Springfield Union Stationbus bus
    3. Take the bus from Springfield Union Station to Ithacabus bus
    4. Take the bus from Ithaca to Buffalobus bus
    17h 39m
    $90–212
  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    14h 56m
    $100–201
  4. Train (Amtrak)

    1. Take the train from Saco Amtrak Station to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 14m
    $169–427
  5. Drive 494.2 mi

    1. Drive from Saco to Buffalocar car 494.2 mi
    10h 6m
    $91–131
  6. Fly Portland to Buffalo Niagara International Airport

    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    8h 7m
    $293–1,645
  7. Train to Boston Logan Airport, fly to Rochester, bus

    1. Take the train from Saco Amtrak Station to Woburn Amtrak Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 46m
    $290–857

Saco to Buffalo by bus

Calendar7Weekly Buses
Duration14h 56mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

What companies run services between Saco, ME, USA and Buffalo, NY, USA?

You can take a bus from Dyer Library to Buffalo via Portland Public Library, Portland, ME, Boston, MA - South Station, and Boston in around 14h 56m. Alternatively, you can take a train from Saco Amtrak Station to Buffalo via Boston, North Station, Back Bay, Boston, and Buffalo Depew Station in around 16h 14m.

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