There are 8 ways to get from Rome to Mytilene by plane, train, ferry, bus, car ferry or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Recommended option
Fly Rome to Mytilini • 6h 40m
Cheapest option
Fly Rome to Chios, ferry • 10h 35m
6 alternative options
Train to Naples, fly to Mytilini • 9h 11m
Train, ferry, bus, car ferry • 28h 49m
Train, Bus, ferry • 46h 39m
Bus, ferry • 2 days 1h
Bus, car ferry • 2 days 7h
Drive, car ferry • 32h 4m
Questions & Answers
What is the cheapest way to get from Rome to Mytilene?
The cheapest way to get from Rome to Mytilene is to fly and ferry which costs €85 - €330 and takes 10h 35m.
What is the fastest way to get from Rome to Mytilene?
The quickest way to get from Rome to Mytilene is to fly which costs €110 - €340 and takes 6h 40m.
How far is it from Rome to Mytilene?
The distance between Rome and Mytilene is 1227 km.
How do I travel from Rome to Mytilene without a car?
The best way to get from Rome to Mytilene without a car is to train and ferry and bus and car ferry which takes 28h 49m and costs €210 - €600.
How long does it take to get from Rome to Mytilene?
It takes approximately 6h 40m to get from Rome to Mytilene, including transfers.
How long is the flight from Rome to Mytilene?
There is no direct flight from Rome Airport to Mytilini Airport. The quickest flight takes 6h 10m and has one stopover.
What is the time difference between Rome and Mytilene?
Mytilene is 1h ahead of Rome. It is currently 3:50 AM in Rome and 4:50 AM in Mytilene.
Which airlines fly from Rome Airport to Mytilini Airport?
TUI fly Belgium, Brussels Airlines, Sky Express and two other airlines offer flights from Rome Airport to Mytilini Airport.
Where can I stay near Mytilene?
There are 152+ hotels available in Mytilene. Prices start at €35 per night.
How do I get to Rome (FCO) Airport from Rome?
The best way to get from Rome to Rome Airport is to train which takes 32 min and costs €7 - €35.
Launch map view
- Distance: 1226.6 km
- Duration: 6h 40m
What companies run services between Rome, Italy and Mytilene, Greece?
Sky Express, Brussels Airlines and three other airlines fly from Rome to Mytilene 5 times a day.
Airlines
- Website
- en.aegeanair.com
Flights from Rome to Mytilini via Thessaloniki, Athens
- Ave. Duration
- 6h 10m
- When
- Monday, Wednesday and Friday
- Estimated price
- €65 - €240
Flights from Rome to Mytilini via Athens
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- €80 - €260
Flights from Naples to Mytilini via Athens
- Ave. Duration
- 10h
- When
- Monday and Friday
- Estimated price
- €65 - €240
Flights from Naples to Mytilini via Mykonos, Athens
- Ave. Duration
- 6h 57m
- When
- Saturday and Sunday
- Estimated price
- €50 - €240
Flights from Naples to Mytilini via Thessaloniki
- Ave. Duration
- 5h 30m
- When
- Sunday
- Estimated price
- €26 - €180
Flights from Naples to Mytilini via Munich, Thessaloniki
- Ave. Duration
- 7h 5m
- When
- Friday and Sunday
- Estimated price
- €85 - €310
Flights from Rome to Chios via Thessaloniki
- Ave. Duration
- 4h
- When
- Monday and Friday
- Estimated price
- €50 - €200
Flights from Rome to Chios via Athens
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- €60 - €210
Flights from Rome to Chios via Athens, Thessaloniki
- Ave. Duration
- 7h 15m
- When
- Friday
- Estimated price
- €60 - €210
- Website
- skyexpress.gr
Flights from Rome to Mytilini via Athens
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- €110 - €290
Flights from Naples to Mytilini via Athens
- Ave. Duration
- 8h 45m
- When
- Thursday and Sunday
- Estimated price
- €45 - €240
Flights from Naples to Mytilini via Rome, Athens
- Ave. Duration
- 6h 25m
- When
- Monday, Thursday, Friday, Saturday and Sunday
- Estimated price
- €95 - €300
Flights from Rome to Chios via Athens
- Ave. Duration
- 4h 50m
- When
- Saturday
- Estimated price
- €50 - €220
- Website
- brusselsairlines.com
Flights from Rome to Mytilini via Brussels
- Ave. Duration
- 8h 25m
- When
- Friday
- Estimated price
- €160 - €420
- Website
- tuifly.be
Flights from Rome to Mytilini via Brussels
- Ave. Duration
- 8h 50m
- When
- Friday
- Estimated price
- €110 - €380
Train operators
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Napoli Centrale
- Ave. Duration
- 1h 15m
- Frequency
- Every 30 minutes
- Estimated price
- €19 - €65
- Website
- https://www.trenitalia.com/en/frecce.html
- Super Economy
- €19 - €26
- Base Standard
- €35 - €50
- Base Premium
- €45 - €65
Train from Roma Termini to Bari Centrale
- Ave. Duration
- 4h 7m
- Frequency
- Every 4 hours
- Estimated price
- €35 - €110
- Website
- https://www.trenitalia.com/en/frecce.html
- Super Economy
- €35 - €50
- Base Standard
- €60 - €85
- Base Premium
- €75 - €110
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Napoli Centrale
- Ave. Duration
- 2h 3m
- Frequency
- Every 2 hours
- Estimated price
- €15 - €20
- Website
- https://www.trenitalia.com/
- 2nd Class
- €15 - €20
Train from Roma Termini to Bari Centrale
- Ave. Duration
- 6h 23m
- Frequency
- Once daily
- Estimated price
- €29 - €40
- Website
- https://www.trenitalia.com/
- 2nd Class
- €29 - €40
Train from Roma Termini to Ancona
- Ave. Duration
- 3h 43m
- Frequency
- Twice daily
- Estimated price
- €18 - €25
- Website
- https://www.trenitalia.com/
- 2nd Class
- €18 - €25
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Napoli Centrale
- Ave. Duration
- 2h 2m
- Frequency
- Hourly
- Estimated price
- €16 - €55
- Website
- https://www.italotreno.it/en
- Smart Economy
- €19 - €27
- Smart Low Cost
- €16 - €21
- Smart Flex
- €35 - €55
Train from Roma Termini to Bari Centrale
- Ave. Duration
- 4h 20m
- Frequency
- 3 times a day
- Estimated price
- €30 - €80
- Website
- https://www.italotreno.it/en
- Smart Economy
- €30 - €45
- Smart Low Cost
- €30 - €40
- Smart Flex
- €55 - €80
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Napoli Centrale
- Ave. Duration
- 3h
- Frequency
- Every 4 hours
- Estimated price
- €17 - €30
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €27 - €30
Train from Roma Termini to Ancona
- Ave. Duration
- 3h 53m
- Frequency
- 5 times a day
- Estimated price
- €21 - €40
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €33 - €37
Frequently asked questions
Is there Wi-Fi on Trenitalia?
Yes - Wi-Fi is available on both Frecciarossa and Frecciargento services, and may be accessed free of charge. Services require either a mobile phone number or credit card for verification purposes and allow access for 24 hours.
Are there power outlets on Trenitalia?
Yes - Frecce services include a power socket for each seat.
Does Trenitalia offer meals or snacks?
Yes - Frecciarossa and Frecciargento services often offer bar and restaurant options, though this depends on the individual route and train type. Business, Premium and First Class tickets include a complimentary drink and snack. Some services may offer restaurant, FRECCIABistro or pre-booked, in-seat meal options. Please check your service as options vary.
Bus operators
- Phone
- 2665 0 22309
- info@ktel-thesprotias.gr
- Website
- ktel-thesprotias.gr
Bus from Igoumenitsa to Thessaloniki Macedonia KTEL Bus Station
- Ave. Duration
- 5h
- Frequency
- Twice daily
- Estimated price
- €30 - €40
- Website
- KTEL Thesprotias
- Website
- portokalidistours.gr
Bus from Ancona to Drama
- Ave. Duration
- 31h 45m
- Frequency
- Hourly
- Estimated price
- €170 - €250
- Schedules at
- portokalidistours.gr
- Phone
- 085.43212
- info@tuabruzzo.it
- Website
- tuabruzzo.it
Bus from Roma Tiburtina TiBus to L'Aquila
- Ave. Duration
- 1h 55m
- Frequency
- Every 3 hours
- Estimated price
- €9 - €14
- Schedules at
- tuabruzzo.it
- .
- €9 - €14
- Phone
- +389 42 217 370
- durmotours@yahoo.com
- Website
- durmotours.com.mk
Bus from L'Aquila to Skopje
- Ave. Duration
- 29h 9m
- Frequency
- Once a week
- Estimated price
- €65 - €110
- Schedules at
- durmotours.com.mk
- Phone
- 0030 2108219900
- vsiamos@otenet.gr
- Website
- siamostours.com
Bus from Skopje Airport to Thessaloniki
- Ave. Duration
- 3h 30m
- Frequency
- Once a week
- Estimated price
- €13 - €16
- Schedules at
- siamostours.com
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.de
Bus from Roma Tiburtina TiBus to Bucharest
- Ave. Duration
- 33h 25m
- Frequency
- Twice a week
- Estimated price
- €160 - €230
- Website
- https://www.flixbus.co.uk
Bus from Bucharest to İstanbul Esenler bus station
- Ave. Duration
- 11h 10m
- Frequency
- 4 times a week
- Estimated price
- €45 - €70
- Website
- https://www.flixbus.co.uk
Frequently asked questions
Is there Wi-Fi on FlixBus?
Yes - FlixBus offers free Wi-Fi
Are there power outlets on FlixBus?
Yes
Does FlixBus offer meals or snacks?
Yes - snacks and drinks may be purchased from the driver. Please note, this is not available on all services.
- Phone
- 0850 222 34 55
- iletisim@metroturizm.com.tr
- Website
- metroturizm.com.tr
Bus from Istanbul Otogar to Ayvalik
- Ave. Duration
- 6h 37m
- Frequency
- 3 times a day
- Estimated price
- €8 - €19
- Website
- https://www.metroturizm.com.tr/en
Ferry operators
- Phone
- +30 210 89 19 800
- hellenicseaways@hellenicseaways.gr
- Website
- hellenicseaways.gr
Ferry from Chios to Mytilene
- Ave. Duration
- 3h
- Frequency
- 6 times a week
- Estimated price
- €26 - €85
- Website
- https://www.hellenicseaways.gr/en-gb
- Business
- €45 - €65
- 4 Bed Inside Cabin
- €35 - €55
- Economy
- €26 - €40
- 2 Bed Lux Cabin
- €60 - €85
- Phone
- +302108919800
- bluestarferries@bluestarferries.com
- Website
- bluestarferries.com
Ferry from Chios to Mytilene
- Ave. Duration
- 2h 15m
- Frequency
- Twice a week
- Estimated price
- €25 - €80
- Website
- https://www.bluestarferries.com/en-gb/
- Business
- €65 - €75
- 2 Bed Inside Cabin
- €55 - €70
- Economy
- €25 - €35
- 4 Bed Outside Cabin
- €45 - €55
- 2 Bed Lux Cabin
- €60 - €80
Ferry from Kavala to Mytilene
- Ave. Duration
- 7h 55m
- Frequency
- Once a week
- Estimated price
- €35 - €100
- Website
- https://www.bluestarferries.com/en-gb/
- Business
- €75 - €85
- 2 Bed Inside Cabin
- €65 - €80
- Economy
- €35 - €55
- 4 Bed Outside Cabin
- €60 - €70
- 2 Bed Lux Cabin
- €80 - €100
Ferry from Thessaloniki to Mytilene
- Ave. Duration
- 10h 5m
- Frequency
- Once a week
- Estimated price
- €40 - €110
- Website
- https://www.bluestarferries.com/en-gb/
- Business
- €75 - €85
- 2 Bed Inside Cabin
- €70 - €85
- Economy
- €40 - €60
- 4 Bed Outside Cabin
- €65 - €80
- 2 Bed Lux Cabin
- €85 - €110
- Phone
- +30 210 8919700
- superfast@superfast.com
- Website
- superfast.com
Ferry from Bari M.ma to Igoumenitsa
- Ave. Duration
- 9h
- Frequency
- Once daily
- Estimated price
- €50 - €180
- Website
- https://www.superfast.com
- 2 bed inside cabin
- €170 - €180
- Deck
- €53
- Aircraft-type seats
- €59
- 3 bed outside cabin
- €136
Car ferry from Ancona to Igoumenitsa
- Ave. Duration
- 17h 30m
- Frequency
- 6 times a week
- Estimated price
- €65 - €220
- Website
- https://www.superfast.com
- 2 bed inside cabin
- €190 - €220
- Deck
- €65 - €90
- Aircraft-type seats
- €80 - €95
- 3 bed outside cabin
- €180 - €210
- Phone
- +30 210 4121001
- info@seajets.gr
- Website
- seajets.com
Car ferry from Thessaloniki to Mytilene
- Ave. Duration
- 7h 10m
- Frequency
- Twice a week
- Estimated price
- €80 - €210
- Website
- https://www.seajets.com/
- Deck Fare Economy
- €80 - €120
- Deck Fare Economy & Car less than 4.25m
- €150 - €210
- Phone
- 0545 783 50 61
- info@jalemtur.com
- Website
- jalemtur.com
Car ferry from Ayvalık to Mytilene
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- €25
- Schedules at
- jalemtur.com
Want to know more about travelling around Greece
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.