There are 7 ways to get from Rome to Mainz by plane, train (Trenitalia), bus, car, train, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Fiumicino International Airport
best- Fly from Fiumicino International Airport (FCO) to Frankfurt (FRA)plane FCO - FRA
4h 57m€55–191Train
- Take the train from Roma Termini to Milano Centraletrain Fr / ...
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
12h 35m€171–312Bus via Pescara
- Take the bus from Roma Termini Giolitti to Pescarabus
- Take the bus from Pescara to Frankfurtbus
18h 48m€110–140Drive 1,231.2 km
- Drive from Rome to Mainzcar 1,231.2 km
11h 29m€192–277Train to Florence Peretola Airport, fly
- Take the train from Roma Termini to Florence Santa Maria Novellatrain
- Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane FLR - FRA
6h 6m€132–343Bus
- Take the bus from Roma, Autostazione Tiburtina to Frankfurt central train stationbus N77
22h 35m€64–173Drive, car train
- Drive from Rome to Villach Hbfcar
- Take the car train from Villach Hbf to Würzburg Hbfcartrain
- Drive from Würzburg Hbf to Mainzcar
11h 50m€237–326
Rome to Mainz by train
Questions & Answers
The cheapest way to get from Rome to Mainz is to fly which costs €55 - €200 and takes 4h 57m.
The fastest way to get from Rome to Mainz is to fly which takes 4h 57m and costs €55 - €200.
No, there is no direct bus from Rome to Mainz station. However, there are services departing from Roma, Autostazione Tiburtina and arriving at Mainz central train station via Frankfurt central train station. The journey, including transfers, takes approximately 22h 35m.
No, there is no direct train from Rome to Mainz. However, there are services departing from Roma Termini and arriving at Mainz, Römisches Theater via Milano Centrale and Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 12h 35m.
The distance between Rome and Mainz is 1019 km. The road distance is 1231.2 km.
The best way to get from Rome to Mainz without a car is to train which takes 12h 35m and costs €170 - €320.
It takes approximately 4h 57m to get from Rome to Mainz, including transfers.
Rome to Mainz bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Mainz train services, operated by Trenitalia Frecce, depart from Roma Termini station.
The best way to get from Rome to Mainz is to fly which takes 4h 57m and costs €55 - €200. Alternatively, you can train, which costs €170 - €320 and takes 12h 35m, you could also bus via Pescara, which costs €110 - €140 and takes 18h 48m.
What companies run services between Rome, Italy and Mainz, Germany?
easyJet, Condor Flugdienst, and three other airlines fly from Fiumicino International Airport (FCO) to Frankfurt (FRA) every 2 hours. Alternatively, you can take a train from Roma Termini to Mainz, Römisches Theater via Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 12h 35m.
- Website
- lufthansa.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 58m
- When
- Every day
- Estimated price
- €65–410
Flights from Fiumicino International Airport to Frankfurt via Milan Linate
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €95–310
Flights from Fiumicino International Airport to Frankfurt via Munich
- Ave. Duration
- 3h 46m
- When
- Every day
- Estimated price
- €75–190
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–250
Flights from Florence Peretola Airport to Frankfurt via Munich
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €110–250
- Website
- ita-airways.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 58m
- When
- Every day
- Estimated price
- €65–410
Flights from Fiumicino International Airport to Frankfurt via Milan Linate
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €95–310
Flights from Fiumicino International Airport to Frankfurt via Munich
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- €75–190
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–250
- Website
- airdolomiti.it
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–250
- Website
- swiss.com
Flights from Florence Peretola Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 35m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €85–330
- Website
- easyjet.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- €40–140
- Website
- condor.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- €50–220
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 8m
- Frequency
- Every 30 minutes
- Estimated price
- €35–110
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
Train from Roma Termini to Florence Santa Maria Novella
- Ave. Duration
- 1h 32m
- Frequency
- Hourly
- Estimated price
- €22–60
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Villach Hbf to Würzburg Hbf
- Ave. Duration
- 3h 34m
- Frequency
- Once daily
- Estimated price
- €95–120
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +39 0873 364785
- info@difonzobus.com
- Website
- difonzobus.com
Bus from Roma Termini Giolitti to Pescara
- Ave. Duration
- 2h 10m
- Frequency
- Every 4 hours
- Estimated price
- €12–15
- Schedules at
- difonzobus.com
- Phone
- +39 098 3520 315
- info@fsbusitaliafast.it
- Website
- simetbus.it
Bus from Pescara to Frankfurt
- Ave. Duration
- 14h 50m
- Frequency
- Once a week
- Estimated price
- €90–110
- Schedules at
- simetbus.it
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Roma, Autostazione Tiburtina to Frankfurt central train station
- Ave. Duration
- 20h 55m
- Frequency
- Once daily
- Estimated price
- €55–170
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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More Questions & Answers
Rome to Mainz bus services, operated by FlixBus, arrive at Frankfurt central train station.
Rome to Mainz train services, operated by Trenitalia Frecce, arrive at Milano Centrale station.
Yes, the driving distance between Rome to Mainz is 1231 km. It takes approximately 11h 29m to drive from Rome to Mainz.
Book your Rome to Mainz bus tickets online with Omio and FlixBus.
There are 1121+ hotels available in Mainz.

































