There are 7 ways to get from Rome to Mainz by plane, train (Trenitalia), bus, car, train, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Frankfurt
best- Fly from Fiumicino International Airport (FCO) to Frankfurt (FRA)plane FCO - FRA
4h 59m€51–168Train
- Take the train from Roma Termini to Milano Centraletrain Fr / ...
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
12h 35m€207–356Bus via Pescara
- Take the bus from Roma Termini Giolitti to Pescarabus
- Take the bus from Pescara to Frankfurtbus
18h 49m€110–140Drive 1,231.3 km
- Drive from Rome to Mainzcar 1,231.3 km
11h 29m€190–274Fly to Cologne Bonn Airport, train
- Fly from Fiumicino International Airport (FCO) to Cologne Bonn Airport (CGN)plane FCO - CGN
- Take the train from Siegburg/Bonn to Frankfurt(M) Flughafen Fernbftrain
6h 40m€97–324Bus
- Take the bus from Roma, Autostazione Tiburtina to Frankfurt central train stationbus N77
22h 35m€84–142Drive, car train
- Drive from Rome to Villach Hbfcar
- Take the car train from Villach Hbf to Würzburg Hbfcartrain
- Drive from Würzburg Hbf to Mainzcar
11h 50m€236–324
Rome to Mainz by train
Questions & Answers
The cheapest way to get from Rome to Mainz is to fly which costs €50 - €170 and takes 4h 59m.
The fastest way to get from Rome to Mainz is to fly which takes 4h 59m and costs €50 - €170.
No, there is no direct bus from Rome to Mainz station. However, there are services departing from Roma, Autostazione Tiburtina and arriving at Mainz central train station via Frankfurt central train station. The journey, including transfers, takes approximately 22h 35m.
No, there is no direct train from Rome to Mainz. However, there are services departing from Roma Termini and arriving at Mainz, Römisches Theater via Milano Centrale and Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 12h 35m.
The distance between Rome and Mainz is 1019 km. The road distance is 1231.3 km.
The best way to get from Rome to Mainz without a car is to train which takes 12h 35m and costs €200 - €360.
It takes approximately 4h 59m to get from Rome to Mainz, including transfers.
Rome to Mainz bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Mainz train services, operated by Trenitalia Frecce, depart from Roma Termini station.
The best way to get from Rome to Mainz is to fly which takes 4h 59m and costs €50 - €170. Alternatively, you can train, which costs €200 - €360 and takes 12h 35m, you could also bus via Pescara, which costs €110 - €140 and takes 18h 49m.
What companies run services between Rome, Italy and Mainz, Germany?
easyJet, Condor Flugdienst, and three other airlines fly from Fiumicino International Airport (FCO) to Frankfurt (FRA) every 3 hours. Alternatively, you can take a train from Roma Termini to Mainz, Römisches Theater via Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 12h 35m.
- Website
- ita-airways.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- €65–360
Flights from Fiumicino International Airport to Frankfurt via Florence
- Ave. Duration
- 3h 25m
- When
- Sunday
- Estimated price
- €85–320
Flights from Fiumicino International Airport to Frankfurt via Milan Linate
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €85–320
Flights from Fiumicino International Airport to Cologne Bonn Airport
- Ave. Duration
- 2h 5m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- €65–200
Flights from Fiumicino International Airport to Cologne Bonn Airport via Bologna
- Ave. Duration
- 4h 40m
- When
- Sunday
- Estimated price
- €65–200
- Website
- lufthansa.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- €65–360
Flights from Fiumicino International Airport to Frankfurt via Florence
- Ave. Duration
- 3h 25m
- When
- Sunday
- Estimated price
- €85–320
Flights from Fiumicino International Airport to Frankfurt via Milan Linate
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €85–320
- Website
- ryanair.com
Flights from Fiumicino International Airport to Cologne Bonn Airport
- Ave. Duration
- 2h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €50–160
- Website
- easyjet.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- €35–130
- Website
- condor.com
Flights from Fiumicino International Airport to Frankfurt
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- €50–190
- Website
- eurowings.com
Flights from Fiumicino International Airport to Cologne Bonn Airport
- Ave. Duration
- 2h 5m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- €65–200
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 8m
- Frequency
- Every 30 minutes
- Estimated price
- €80–160
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 40m
- Frequency
- Every 2 hours
- Estimated price
- €70–95
- Website
- https://www.italotreno.it/en
- Smart Economy
- €70–95
- Smart Flex
- €75–95
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Siegburg/Bonn to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- €23–75
- Website
- https://www.ns.nl/en
- 2nd Class
- €23–35
- 1st Class
- €45–75
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Siegburg/Bonn to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €35–39
- Website
- https://int.bahn.de/en
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Villach Hbf to Würzburg Hbf
- Ave. Duration
- 3h 34m
- Frequency
- Once daily
- Estimated price
- €95–120
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +39 0873 364785
- info@difonzobus.com
- Website
- difonzobus.com
Bus from Roma Termini Giolitti to Pescara
- Ave. Duration
- 2h 10m
- Frequency
- Every 4 hours
- Estimated price
- €12–15
- Schedules at
- difonzobus.com
- Phone
- +39 098 3520 315
- info@fsbusitaliafast.it
- Website
- simetbus.it
Bus from Pescara to Frankfurt
- Ave. Duration
- 14h 50m
- Frequency
- Once a week
- Estimated price
- €90–110
- Schedules at
- simetbus.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Roma, Autostazione Tiburtina to Frankfurt central train station
- Ave. Duration
- 20h 55m
- Frequency
- Once daily
- Estimated price
- €80–140
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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More Questions & Answers
Rome to Mainz bus services, operated by FlixBus, arrive at Frankfurt central train station.
Rome to Mainz train services, operated by Trenitalia Frecce, arrive at Milano Centrale station.
Yes, the driving distance between Rome to Mainz is 1231 km. It takes approximately 11h 29m to drive from Rome to Mainz.
Book your Rome to Mainz bus tickets online with FlixBus.
There are 1155+ hotels available in Mainz.













































