Rome2Rio

How to get fromRochester to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus or train

Find Transport to St. Louis

See all options

There are 6 ways to get from Rochester to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)planeROC - STL
    5h 14m
    $170–873

  2. Bus

    cheapest
    1. Take the bus from Rochester Bus Stop to Buffalobus
    2. Take the bus from Buffalo, NY to Youngstown, OHbus
    3. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus
    4. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus
    21h 35m
    $111–285

  3. Train (Amtrak)

    1. Take the train from Rochester to Chicago Union StationtrainLake Shore Limited
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    17h 29m
    $118–422

  4. Drive 804.8 mi

    1. Drive from Rochester to St. Louiscar804.8 mi
    13h 34m
    $147–213

  5. Bus to Buffalo Niagara International Airport, fly

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)planeBUF - STL
    7h 7m
    $208–1,024

  6. Train, bus

    1. Take the train from Rochester to Chicago Union StationtrainLake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus StationbusFlixBus N2521 / ...
    19h 2m
    $113–277

Rochester to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration17h 29mAverage Duration
Ticket$118Cheapest Price
See schedules

Questions & Answers

What companies run services between Rochester, NY, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a train from Rochester to St. Louis via Chicago Union Station in around 17h 29m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Rochester

Trips to St. Louis

Popular routes