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How to get fromRochester to St. Louisby plane, train (Amtrak), bus (Greyhound), car, bus, or train

Find Transport to St. Louis

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There are 6 ways to get from Rochester to St. Louis by plane, train (Amtrak), bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    5h
    $170–873

  2. Bus to Buffalo Niagara International Airport, fly

    cheapest
    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 58m
    $113–618

  3. Train (Amtrak)

    1. Take the train from Rochester to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    17h 29m
    $475–738

  4. Bus

    1. Take the bus from Rochester Bus Stop to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    17h 50m
    $136–238

  5. Drive  805 mi

    1. Drive from Rochester to St. Louiscar car 805 mi
    13h 45m
    $138–199

  6. Train, bus

    1. Take the train from Rochester to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    18h 47m
    $375–573

Rochester to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration17h 29mAverage Duration
Ticket$475Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Rochester to St. Louis.ExpandLaunch map view
  • Distance: 746 mi
  • Duration: 5h

What companies run services between Rochester, NY, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Rochester to St. Louis via Chicago Union Station in around 17h 29m.

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Want to know more about travelling around United States

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