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There are 8 ways to get from Rochester to Louisville by plane, bus, train, night bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Rochester to Louisville  •  6 h 19 min

  1. Fly from Rochester (ROC) to Louisville (SDF) ROC - SDF

$152 - $804

Cheapest option

Bus Barons Bus  •  16 h 10 min

  1. Take the bus from Rochester, NY to Buffalo, NY 300 / ...
  2. Take the bus from Buffalo, NY to Cincinnati, OH
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$84 - $260

6 alternative options

Bus to Buffalo, fly to Louisville  •  7 h 15 min

  1. Take the bus from Rochester, NY to Buffalo Airport
  2. Fly from Buffalo (BUF) to Louisville (SDF) BUF - SDF

$154 - $781

Fly Rochester to Lexington, bus  •  7 h 52 min

  1. Fly from Rochester (ROC) to Lexington (LEX) ROC - LEX
  2. Take the bus from Lexington, KY to Louisville, KY

$209 - $986

Train, night bus, bus  •  15 h 10 min

  1. Take the train from Rochester Amtrak Station to Cleveland Amtrak Station
  2. Take the night bus from Cleveland, Oh to Cincinnati, Oh
  3. Take the bus from Cincinnati, Oh to Lexington, Ky
  4. Take the bus from Lexington, KY to Louisville, KY

$114 - $324

Train, bus  •  21 h 31 min

  1. Take the train from Rochester Amtrak Station to Chicago Union Station
  2. Take the train from Chicago Union Station to Indianapolis Amtrak Station
  3. Take the bus from Delaware St & Market St Indianapolis to Louisville, KY

$111 - $265

Bus via Ann Arbor, MI  •  26 h 4 min

  1. Take the bus from Rochester, NY to Toronto, ON
  2. Take the bus from Toronto, ON to Ann Arbor, MI
  3. Take the bus from Ann Arbor, MI to Indianapolis, IN
  4. Take the bus from Indianapolis, IN to Louisville, KY

$107 - $238

Drive  •  10 h 11 min

  1. Drive from Rochester to Louisville 603.7 miles

$55 - $90

Questions & Answers

The cheapest way to get from Rochester to Louisville is to drive which costs $55 - $90 and takes 10 h 11 min.

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The quickest way to get from Rochester to Louisville is to fly which costs $150 - $850 and takes 6 h 19 min.

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No, there is no direct bus from Rochester to Louisville. However, there are services departing from Rochester, NY and arriving at Louisville, KY via Buffalo, NY, Cincinnati, Oh and Lexington, KY. The journey, including transfers, takes approximately 16 h 10 min.

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The distance between Rochester and Louisville is 547 miles. The road distance is 603.7 miles.

Get driving directions

The best way to get from Rochester to Louisville without a car is to train and night bus and bus which takes 15 h 10 min and costs $110 - $330.

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It takes approximately 6 h 19 min to get from Rochester to Louisville, including transfers.

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Rochester to Louisville bus services, operated by Trailways New York, depart from Rochester, NY station.

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The best way to get from Rochester to Louisville is to fly which takes 6 h 19 min and costs $150 - $850. Alternatively, you can bus, which costs $80 - $260 and takes 16 h 10 min.

Mode details

There is no direct flight from Rochester Airport to Louisville Airport. The quickest flight takes 3 h 55 min and has one stopover.

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Rochester to Louisville bus services, operated by Hoosier Ride, arrive at Louisville, KY station.

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Map of how to get from Rochester to Louisville.
Launch map view
  • Distance: 547.3 miles
  • Duration: 6 h 19 min

What companies run services between Rochester, NY, USA and Louisville, KY, USA?

Southwest Airlines, Delta and two other airlines fly from Rochester to Louisville hourly. Alternatively, you can take a bus from Rochester to Louisville via Buffalo, NY, Cincinnati, OH, Cincinnati, Oh, Lexington, Ky, and Lexington, KY in around 16 h 10 min.

Airlines
American Airlines
Website
aa.com
Flights from Rochester to Louisville via Reagan Washington
Ave. Duration
4 h 30 min
When
Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $850
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 1 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$180 - $850
Flights from Rochester to Louisville via Charlotte
Ave. Duration
5 h 19 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $850
Flights from Buffalo to Louisville via Reagan Washington
Ave. Duration
4 h 56 min
When
Wednesday, Thursday, Friday and Saturday
Estimated price
$170 - $800
Flights from Buffalo to Louisville via Charlotte
Ave. Duration
5 h 2 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $800
Flights from Buffalo to Louisville via Philadelphia
Ave. Duration
4 h 38 min
When
Every day
Estimated price
$170 - $800
Flights from Rochester to Lexington via Chicago O'Hare
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Lexington via Philadelphia
Ave. Duration
6 h 5 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Lexington via Charlotte
Ave. Duration
6 h 37 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $900
Delta
Website
delta.com
Flights from Rochester to Louisville via Detroit
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$150 - $800
Flights from Rochester to Louisville via Atlanta
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via New York La Guardia
Ave. Duration
5 h 34 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $850
Flights from Buffalo to Louisville via Detroit
Ave. Duration
4 h 29 min
When
Every day
Estimated price
$140 - $750
Flights from Buffalo to Louisville via Atlanta
Ave. Duration
4 h 57 min
When
Every day
Estimated price
$170 - $850
Flights from Rochester to Lexington via Detroit
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$160 - $850
Flights from Rochester to Lexington via New York La Guardia
Ave. Duration
5 h 7 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from Rochester to Lexington via Atlanta
Ave. Duration
5 h 42 min
When
Every day
Estimated price
$190 - $950
United Airlines
Website
united.com
Flights from Rochester to Louisville via Washington Dulles
Ave. Duration
4 h 7 min
When
Wednesday and Saturday
Estimated price
$190 - $900
Flights from Rochester to Louisville via Chicago O'Hare
Ave. Duration
5 h 11 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Louisville via Newark
Ave. Duration
5 h 24 min
When
Every day
Estimated price
$200 - $900
Flights from Buffalo to Louisville via Washington Dulles
Ave. Duration
4 h 9 min
When
Tuesday, Wednesday and Saturday
Estimated price
$180 - $850
Flights from Buffalo to Louisville via Newark
Ave. Duration
5 h 3 min
When
Monday, Tuesday, Thursday, Friday, Saturday and Sunday
Estimated price
$190 - $900
Flights from Buffalo to Louisville via Chicago O'Hare
Ave. Duration
5 h 30 min
When
Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $850
Flights from Rochester to Lexington via Chicago O'Hare
Ave. Duration
4 h 56 min
When
Every day
Estimated price
$200 - $950
Flights from Rochester to Lexington via Newark
Ave. Duration
5 h 44 min
When
Wednesday, Thursday and Friday
Estimated price
$200 - $950
Southwest Airlines
Website
southwest.com
Flights from Rochester to Louisville via Baltimore
Ave. Duration
4 h 30 min
When
Monday to Saturday
Estimated price
$190 - $800
Flights from Buffalo to Louisville via Baltimore
Ave. Duration
4 h 27 min
When
Wednesday, Thursday, Friday and Saturday
Estimated price
$180 - $800
Flights from Buffalo to Louisville via Chicago Midway
Ave. Duration
4 h 48 min
When
Wednesday and Sunday
Estimated price
$180 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Rochester Amtrak Station to Cleveland Amtrak Station
Ave. Duration
4 h 21 min
Frequency
Twice daily
Estimated price
$45 - $120
Website
amtrak.com
Coach Seat
$45 - $70
Flexi Coach Seat
$80 - $120
Business Coach Seat
$80 - $120
Room
$220 - $310
Train from Rochester Amtrak Station to Chicago Union Station
Ave. Duration
11 h 38 min
Frequency
Twice daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $150
Business Seat
$110 - $150
Bedroom
$460 - $950
Train from Chicago Union Station to Indianapolis Amtrak Station
Ave. Duration
4 h 54 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Trailways New York
Phone
(800) 858-8555
Website
trailwaysny.com
Bus from Rochester, NY to Buffalo Airport
Ave. Duration
1 h 5 min
Frequency
Twice daily
Estimated price
$17 - $24
Book at
trailwaysny.com
Bus from Rochester, NY to Buffalo, NY
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$18 - $26
Book at
trailwaysny.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Rochester, Ny to Buffalo Airport
Ave. Duration
1 h 25 min
Frequency
Once daily
Estimated price
$13 - $29
Website
greyhound.com
Economy
$13 - $19
Flexible
$22 - $29
Night bus from Cleveland, Oh to Cincinnati, Oh
Ave. Duration
4 h 35 min
Frequency
Once daily
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Bus from Cincinnati, Oh to Lexington, Ky
Ave. Duration
1 h 25 min
Frequency
4 times a day
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Rochester, Ny to Buffalo, Ny
Ave. Duration
1 h 30 min
Frequency
Every 4 hours
Estimated price
$13 - $35
Website
greyhound.com
Economy
$13 - $20
Flexible
$24 - $35
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1 h 20 min
Frequency
4 times a day
Estimated price
$21 - $100
Book at
hoosierride.com
Bus from Ann Arbor, MI to Indianapolis, IN
Ave. Duration
8 h 55 min
Frequency
Once daily
Estimated price
$30 - $90
Book at
hoosierride.com
Bus from Indianapolis, IN to Louisville, KY
Ave. Duration
3 h 30 min
Frequency
Once daily
Estimated price
$30 - $45
Book at
hoosierride.com
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Rochester, NY - 186 Cumberland Street to Buffalo, NY - 181 Ellicott Street
Ave. Duration
2 h 25 min
Frequency
Every 4 hours
Estimated price
$12 - $35
Website
Greyhound.ca
Advanced Purchase
$12 - $18
Online Fare
$13 - $28
Standard Fare
$22 - $35
Refundable
$25 - $40
Bus from Toronto, ON to Ann Arbor, MI
Ave. Duration
6 h 19 min
Frequency
Once daily
Estimated price
$29 - $75
Website
Greyhound.ca
Advanced Purchase
$29 - $45
Online Fare
$35 - $60
Standard Fare
$50 - $75
Refundable
$55 - $80
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Delaware St & Market St Indianapolis to Louisville, KY
Ave. Duration
2 h 45 min
Frequency
Twice daily
Estimated price
$12 - $23
Book at
megabus.com
Bus from Rochester, NY to Toronto, ON
Ave. Duration
4 h 20 min
Frequency
Twice daily
Estimated price
$18 - $29
Book at
megabus.com

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Rochester to Louisville is 604 miles. It takes approximately 10 h 11 min to drive from Rochester to Louisville.

Get driving directions

Southwest Airlines, Delta, American Airlines and United Airlines offer flights from Rochester Airport to Louisville Airport.

Search flights

There are 192+ hotels available in Louisville. Prices start at $66 USD per night.

More details

The best way to get from Rochester to Rochester Airport is to line 6 bus which takes 19 min and costs $1.

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