There are 5 ways to get from Rochester to Des Moines by plane, train, bus, bus (Flixbus, Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Rochester
best- Fly from Rochester (ROC) to Des Moines (DSM)plane ROC - DSM
4h 54m$244–1,241Train, bus
cheapest- Take the train from Rochester to Chicago Union Stationtrain Lake Shore Limited
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123 / ...
19h 26m$110–301Bus
- Take the bus from Rochester Bus Stop to Buffalobus
- Take the bus from Buffalo to Cleveland Bus Stationbus
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Des Moinesbus
21h 59m$111–248Drive 915.2 mi
- Drive from Rochester to Des Moinescar 915.2 mi
15h 25m$167–242Bus to Buffalo Niagara International Airport, fly
- Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus
- Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane BUF - DSM
6h 53m$283–1,442
Rochester to Des Moines by train, foot, and bus
Questions & Answers
The cheapest way to get from Rochester to Des Moines is to bus which costs $110 - $250 and takes 21h 59m.
The fastest way to get from Rochester to Des Moines is to fly which takes 4h 54m and costs $240 - $1,300.
No, there is no direct bus from Rochester to Des Moines. However, there are services departing from Rochester Bus Stop and arriving at Des Moines via Buffalo, Cleveland Bus Station and Chicago Bus Station. The journey, including transfers, takes approximately 21h 59m.
The distance between Rochester and Des Moines is 838 miles. The road distance is 920.5 miles.
The best way to get from Rochester to Des Moines without a car is to train and bus which takes 19h 26m and costs $110 - $310.
It takes approximately 4h 54m to get from Rochester to Des Moines, including transfers.
Rochester to Des Moines bus services, operated by Flixbus USA, depart from Rochester Bus Stop station.
The best way to get from Rochester to Des Moines is to fly which takes 4h 54m and costs $240 - $1,300. Alternatively, you can bus, which costs $110 - $250 and takes 21h 59m.
Rochester to Des Moines bus services, operated by Flixbus USA, arrive at Buffalo station.
Des Moines is 1h behind Rochester. It is currently 12:56 AM in Rochester and 11:56 PM in Des Moines.
What companies run services between Rochester, NY, USA and Des Moines, IA, USA?
Delta, American Airlines, and two other airlines fly from Rochester (ROC) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Rochester Bus Stop to Des Moines via Buffalo, Cleveland Bus Station, and Chicago Bus Station in around 21h 59m.
- Website
- aa.com
Flights from Rochester to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 37m
- When
- Every day
- Estimated price
- $210–1,200
Flights from Rochester to Des Moines via Reagan Washington
- Ave. Duration
- 7h 9m
- When
- Every day
- Estimated price
- $260–1,400
Flights from Rochester to Des Moines via Philadelphia
- Ave. Duration
- 8h 13m
- When
- Every day
- Estimated price
- $270–1,400
Flights from Buffalo Niagara International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $250–1,400
Flights from Buffalo Niagara International Airport to Des Moines via Reagan Washington
- Ave. Duration
- 7h 7m
- When
- Every day
- Estimated price
- $340–1,700
Flights from Buffalo Niagara International Airport to Des Moines via Philadelphia
- Ave. Duration
- 8h 13m
- When
- Every day
- Estimated price
- $350–1,700
- Website
- united.com
Flights from Rochester to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $210–1,200
Flights from Buffalo Niagara International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $250–1,400
- Website
- delta.com
Flights from Rochester to Des Moines via Detroit
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $210–1,200
Flights from Rochester to Des Moines via Atlanta
- Ave. Duration
- 5h 41m
- When
- Every day
- Estimated price
- $310–1,500
Flights from Buffalo Niagara International Airport to Des Moines via Detroit
- Ave. Duration
- 5h 7m
- When
- Every day
- Estimated price
- $250–1,400
Flights from Buffalo Niagara International Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 41m
- When
- Every day
- Estimated price
- $390–1,900
- Website
- southwest.com
Flights from Rochester to Des Moines via Chicago Midway
- Ave. Duration
- 7h
- When
- Monday, Thursday, and Friday
- Estimated price
- $210–1,200
Flights from Buffalo Niagara International Airport to Des Moines via Chicago Midway
- Ave. Duration
- 7h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $250–1,400
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Rochester to Chicago Union Station
- Ave. Duration
- 11h 43m
- Frequency
- Twice daily
- Estimated price
- $70–210
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 34m
- Frequency
- 3 times a day
- Estimated price
- $40–95
- Website
- https://www.greyhound.com/
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 25m
- Frequency
- 4 times a day
- Estimated price
- $16–23
- Website
- https://www.greyhound.com/
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 40m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://www.greyhound.com/
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $15–22
- Schedules at
- flixbus.com
Bus from Rochester Bus Stop to Buffalo Niagara International Airport
- Ave. Duration
- 1h 10m
- Frequency
- Every 4 hours
- Estimated price
- $15–22
- Schedules at
- flixbus.com
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 35m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
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More Questions & Answers
Yes, the driving distance between Rochester to Des Moines is 921 miles. It takes approximately 15h 25m to drive from Rochester to Des Moines.
Book your Rochester to Des Moines bus tickets online with Omio and FlixBus.
There are 240+ hotels available in Des Moines.










