There are 5 ways to get from Roanoke to Tupelo by plane, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Golden Triangle Regional Airport, drive
best- Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Golden Triangle Regional Airport (GTR)ROA - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelo
9h$75–371Bus (Greyhound)
- Take the bus from Roanoke Bus Stop to Nashville Bus Station
- Take the bus from Nashville Bus Station to Memphis Bus Station
- Take the bus from Memphis Bus Station to Tupelo
15h 19m$123–279Drive 602.6 mi
- Drive from Roanoke to Tupelo602.6 mi
10h 33m$110–159Fly to Birmingham–Shuttlesworth International Airport, drive
- Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Birmingham–Shuttlesworth International Airport (BHM)ROA - BHM
- Drive from Birmingham-Airport-BHM to Tupelo
7h 17m$118–594Fly to Huntsville International Airport-Carl T Jones Field, drive
- Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Huntsville International Airport-Carl T Jones Field (HSV)ROA - HSV
- Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelo
7h 23m$97–439
Roanoke Regional Airport-Woodrum Field (ROA) to Golden Triangle Regional Airport (GTR) flights
Questions & Answers
The cheapest way to get from Roanoke to Tupelo is to drive which costs $110 - $160 and takes 10h 33m.
The fastest way to get from Roanoke to Tupelo is to fly and drive which takes 7h 17m and costs $110 - $600.
The distance between Roanoke and Tupelo is 626 miles. The road distance is 606.2 miles.
The best way to get from Roanoke to Tupelo without a car is to bus which takes 15h 19m and costs $120 - $280.
It takes approximately 9h to get from Roanoke to Tupelo, including transfers.
Tupelo is 1h behind Roanoke. It is currently 5:42 PM in Roanoke and 4:42 PM in Tupelo.
Yes, the driving distance between Roanoke to Tupelo is 606 miles. It takes approximately 10h 33m to drive from Roanoke to Tupelo.
There are 36+ hotels available in Tupelo.
What companies run services between Roanoke, VA, USA and Tupelo, MS, USA?
You can take a bus from Roanoke Bus Stop to Tupelo via Nashville Bus Station, Memphis Bus Station, and Tupelo in around 15h 19m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- delta.com
Flights from Roanoke Regional Airport-Woodrum Field to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 8h 58m
- When
- Every day
- Estimated price
- $60–350
Flights from Roanoke Regional Airport-Woodrum Field to Golden Triangle Regional Airport via New York La Guardia, Atlanta
- Ave. Duration
- 7h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–500
Flights from Roanoke Regional Airport-Woodrum Field to Golden Triangle Regional Airport via Charlotte, Atlanta
- Ave. Duration
- 6h 22m
- When
- Every day
- Estimated price
- $65–350
Flights from Roanoke Regional Airport-Woodrum Field to Birmingham–Shuttlesworth International Airport via Atlanta
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $90–550
Flights from Roanoke Regional Airport-Woodrum Field to Huntsville International Airport-Carl T Jones Field via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $70–410
- Website
- aa.com
Flights from Roanoke Regional Airport-Woodrum Field to Birmingham–Shuttlesworth International Airport via Charlotte
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $90–550
Flights from Roanoke Regional Airport-Woodrum Field to Birmingham–Shuttlesworth International Airport via Philadelphia
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $140–700
Flights from Roanoke Regional Airport-Woodrum Field to Huntsville International Airport-Carl T Jones Field via Charlotte
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $70–400
Flights from Roanoke Regional Airport-Woodrum Field to Huntsville International Airport-Carl T Jones Field via Chicago O'Hare
- Ave. Duration
- 6h 18m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–550
- Website
- united.com
Flights from Roanoke Regional Airport-Woodrum Field to Birmingham–Shuttlesworth International Airport via Chicago O'Hare
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $140–700
Flights from Roanoke Regional Airport-Woodrum Field to Huntsville International Airport-Carl T Jones Field via Washington Dulles
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $90–470
Flights from Roanoke Regional Airport-Woodrum Field to Huntsville International Airport-Carl T Jones Field via Chicago O'Hare
- Ave. Duration
- 7h 37m
- When
- Every day
- Estimated price
- $110–550
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Roanoke Bus Stop to Nashville Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $55–130
- Website
- https://www.greyhound.com/
Bus from Nashville Bus Station to Memphis Bus Station
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $35–85
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $19–60
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide


