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How to get fromRoanoke to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car or train

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There are 6 ways to get from Roanoke to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL)plane plane ROA - STL
    6h 44m
    $137–757

  2. Bus

    cheapest
    1. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 10m
    $107–225

  3. Train (Amtrak)

    1. Take the train from Roanoke to Charlottesvilletrain train
    2. Take the train from Charlottesville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    30h 22m
    $256–806

  4. Drive 673.8 mi

    1. Drive from Roanoke to St. Louiscar car 673.8 mi
    11h 35m
    $123–178

  5. Drive to Greenbrier Valley Airport, fly

    1. Drive from Roanoke to Greenbrier Valley Airport (LWB)car car
    2. Fly from Greenbrier Valley Airport (LWB) to Lambert–St. Louis International Airport (STL)plane plane LWB - STL
    7h 23m
    $206–1,121

  6. Train to Lynchburg Regional Airport, fly

    1. Take the train from Roanoke to Lynchburgtrain train
    2. Fly from Lynchburg Regional Airport (LYH) to Lambert–St. Louis International Airport (STL)plane plane LYH - STL
    9h 8m
    $152–1,011

Roanoke to St. Louis by bus

Calendar7Weekly Buses
Duration15h 10mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

What companies run services between Roanoke, VA, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and Delta fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Roanoke Bus Stop to St Louis Bus Station via Nashville Bus Station in around 15h 10m.

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