There are 7 ways to get from Roanoke to Lexington by plane, bus (Greyhound), train, bus, car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Roanoke Regional Airport-Woodrum Field
best- Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Blue Grass Airport (LEX)ROA - LEX
7h 50m$126–756Drive 343.2 mi
cheapest- Drive from Roanoke to Lexington343.2 mi
6h 11m$63–91Bus (Greyhound)
- Take the bus from Roanoke Bus Stop to Nashville Bus Station
- Take the bus from Nashville Bus Station to Cincinnati Bus Station
- Take the bus from Cincinnati Bus Station to Lexington Bus Stop
17h 17m$154–288Train, bus
- Take the train from Roanoke to Charlottesville
- Take the train from Charlottesville to Indianapolis
- Take the bus from Indianapolis Union Station to Lexington Bus Stop
23h 53m$128–538Drive to Greenbrier Valley Airport, fly
- Drive from Roanoke to Greenbrier Valley Airport (LWB)
- Fly from Greenbrier Valley Airport (LWB) to Blue Grass Airport (LEX)LWB - LEX
8h 38m$185–1,120Train to Lynchburg Regional Airport, fly
- Take the train from Roanoke to Lynchburg
- Fly from Lynchburg Regional Airport (LYH) to Blue Grass Airport (LEX)LYH - LEX
10h 16m$131–960Bus, taxi
- Take the bus from 3rd St Station Slip D to Perry Street Slip 1Swb
- Take the taxi from The HUB to Wytheville
- Take the bus from Wytheville to Columbus - Mound St
- Take the bus from Columbus - Downtown - Mound St to Greyhound Station Cincinnati
- Take the bus from Cincinnati Bus Station to Lexington Bus Stop
19h 22m$146–277
Roanoke Regional Airport-Woodrum Field (ROA) to Blue Grass Airport (LEX) flights
Questions & Answers
The cheapest way to get from Roanoke to Lexington is to drive which costs $60 - $95 and takes 6h 11m.
The fastest way to get from Roanoke to Lexington is to drive which takes 6h 11m and costs $60 - $95.
The distance between Roanoke and Lexington is 281 miles. The road distance is 345.2 miles.
The best way to get from Roanoke to Lexington without a car is to bus which takes 17h 17m and costs $150 - $290.
It takes approximately 7h 50m to get from Roanoke to Lexington, including transfers.
The best way to get from Roanoke to Lexington is to fly which takes 7h 50m and costs $120 - $800. Alternatively, you can bus, which costs $150 - $290 and takes 17h 17m.
Yes, the driving distance between Roanoke to Lexington is 345 miles. It takes approximately 6h 11m to drive from Roanoke to Lexington.
There are 135+ hotels available in Lexington.
What companies run services between Roanoke, VA, USA and Lexington, KY, USA?
Delta, American Airlines, and United Airlines fly from Roanoke Regional Airport-Woodrum Field (ROA) to Blue Grass Airport (LEX) every 3 hours. Alternatively, you can take a bus from Roanoke Bus Stop to Lexington via Nashville Bus Station, Cincinnati Bus Station, and Lexington Bus Stop in around 17h 17m.
- Website
- aa.com
Flights from Roanoke Regional Airport-Woodrum Field to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $120–750
Flights from Greenbrier Valley Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 52m
- When
- Monday, Tuesday, Wednesday, and Friday
- Estimated price
- $170–1,100
Flights from Greenbrier Valley Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 7h 34m
- When
- Monday, Friday, and Sunday
- Estimated price
- $240–1,300
Flights from Lynchburg Regional Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $120–750
- Website
- delta.com
Flights from Roanoke Regional Airport-Woodrum Field to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $150–850
- Website
- united.com
Flights from Roanoke Regional Airport-Woodrum Field to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $180–950
Flights from Lynchburg Regional Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 41m
- When
- Tuesday to Saturday
- Estimated price
- $180–950
Rome2Rio's guide to Amtrak Northeast Regional
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Roanoke to Charlottesville
- Ave. Duration
- 2h 28m
- Frequency
- Twice daily
- Estimated price
- $15–240
- Website
- https://www.amtrak.com/home.html
- Schedules at
- https://www.amtrak.com/northeast-regional-train
- Coach
- $15–240
- Business Class
- $65–280
Train from Roanoke to Lynchburg
- Ave. Duration
- 1h 14m
- Frequency
- Twice daily
- Estimated price
- $7–210
- Website
- https://www.amtrak.com/home.html
- Schedules at
- https://www.amtrak.com/northeast-regional-train
- Coach
- $7–210
- Business Class
- $50–240
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Charlottesville to Indianapolis
- Ave. Duration
- 15h 23m
- Frequency
- 3 times a week
- Estimated price
- $55–200
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $55–150
- Coach Seat short notice purchase
- $75–200
- Business - advance purchase
- $100–440
- Business Class
- $170–450
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Roanoke Bus Stop to Nashville Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $65–120
- Website
- https://www.greyhound.com/
Bus from Nashville Bus Station to Cincinnati Bus Station
- Ave. Duration
- 5h 20m
- Frequency
- Twice daily
- Estimated price
- $40–95
- Website
- https://www.greyhound.com/
Bus from Cincinnati Bus Station to Lexington Bus Stop
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $20–50
- Website
- https://www.greyhound.com/
Bus from Indianapolis Union Station to Lexington Bus Stop
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $30–70
- Website
- https://www.greyhound.com/
Bus from Columbus - Downtown - Mound St to Greyhound Station Cincinnati
- Ave. Duration
- 4h 10m
- Frequency
- Once daily
- Estimated price
- $21–45
- Website
- https://www.greyhound.com/
- Phone
- +1 540 982 2222
- info@valleymetro.com
- Website
- valleymetro.com
Bus from 3rd St Station Slip D to Perry Street Slip 1
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $1–4
- Website
- https://www.valleymetro.com
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Wytheville to Columbus - Mound St
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Estimated price
- $30–75
- Website
- https://baronsbus.com
Bus from Columbus - Downtown - Mound St to Greyhound Station Cincinnati
- Ave. Duration
- 2h 11m
- Frequency
- Once daily
- Estimated price
- $10–45
- Website
- https://baronsbus.com
- Ave. Duration
- 33 min
- Estimated price
- $70–85
Text-A-Cab
- Phone
- +1-540-239-9724
Blacksburg Taxi
- Phone
- +1 540-552-6671
- Website
- blacksburgtaxi.com
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