There are 5 ways to get from Presque Isle to Buffalo by plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Amtrak, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Presque Isle (PQI) to Buffalo Niagara International Airport (BUF)plane PQI - BUF
8h 53m$222–1,237Drive 754.7 mi
cheapest- Drive from Presque Isle to Buffalocar 754.7 mi
15h 14m$138–199Bus
- Take the bus from Presque Isle, Maine to Bangor, MEbus
- Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus
- Take the bus from Boston to Buffalobus
19h 51m$141–251Bus, train
- Take the bus from Presque Isle, Maine to Bangor, MEbus
- Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus
- Take the train from Boston to Buffalo Depew Stationtrain
22h 46m$205–466Bus via Ithaca
- Take the bus from Presque Isle, Maine to Bangor, MEbus
- Take the bus from Bangor Transportation Center to Boston, MA - South Stationbus
- Take the bus from Boston to Ithacabus
- Take the bus from Ithaca to Buffalobus
22h 10m$139–286
Presque Isle to Buffalo by bus
Questions & Answers
The cheapest way to get from Presque Isle to Buffalo is to drive which costs $130 - $200 and takes 15h 14m.
The fastest way to get from Presque Isle to Buffalo is to fly which takes 8h 53m and costs $220 - $1,300.
No, there is no direct bus from Presque Isle to Buffalo. However, there are services departing from Presque Isle, Maine and arriving at Buffalo via Bangor Transportation Center and Boston. The journey, including transfers, takes approximately 19h 51m.
The distance between Presque Isle and Buffalo is 599 miles. The road distance is 759.1 miles.
The best way to get from Presque Isle to Buffalo without a car is to bus which takes 19h 51m and costs $140 - $260.
It takes approximately 8h 53m to get from Presque Isle to Buffalo, including transfers.
Presque Isle to Buffalo bus services, operated by Cyr Bus Line, depart from Presque Isle, Maine station.
The best way to get from Presque Isle to Buffalo is to fly which takes 8h 53m and costs $220 - $1,300. Alternatively, you can bus, which costs $140 - $260 and takes 19h 51m.
Presque Isle to Buffalo bus services, operated by Cyr Bus Line, arrive at Bangor, ME station.
Yes, the driving distance between Presque Isle to Buffalo is 759 miles. It takes approximately 15h 14m to drive from Presque Isle to Buffalo.
What companies run services between Presque Isle, ME, USA and Buffalo, NY, USA?
JetBlue Airways flies from Presque Isle (PQI) to Buffalo Niagara International Airport (BUF) once daily. Alternatively, you can take a bus from Presque Isle, Maine to Buffalo via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, and Boston in around 19h 51m.
- Website
- jetblue.com
Flights from Presque Isle to Buffalo Niagara International Airport via Boston
- Ave. Duration
- 7h 42m
- When
- Every day
- Estimated price
- $210–1,200
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Boston to Buffalo Depew Station
- Ave. Duration
- 11h 39m
- Frequency
- Once daily
- Estimated price
- $130–290
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 207-942-3354
- Website
- johntcyrandsons.com
Bus from Presque Isle, Maine to Bangor, ME
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $26–35
- Website
- http://johntcyrandsons.com
- Phone
- +1 800 639 3317
- info@concordcoachlines.com
- Website
- concordcoachlines.com
Bus from Bangor Transportation Center to Boston, MA - South Station
- Ave. Duration
- 4h 25m
- Frequency
- Every 4 hours
- Estimated price
- $50–70
- Website
- https://concordcoachlines.com
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Bangor Transportation Center to Boston, MA - South Station
- Ave. Duration
- 4h 25m
- Frequency
- 5 times a day
- Estimated price
- $43–48
- Website
- https://www.amtrak.com/home.html
- Adult
- $43–48
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Boston to Buffalo
- Ave. Duration
- 10h 5m
- Frequency
- Once daily
- Estimated price
- $75–150
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Boston to Ithaca
- Ave. Duration
- 7h 44m
- Frequency
- 5 times a week
- Estimated price
- $45–85
- Schedules at
- flixbus.com
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Schedules at
- flixbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Ithaca to Buffalo
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $28–100
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $28–95
- Flexible
- $55–100
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 573+ hotels available in Buffalo.










