FlixBus operates a bus from Prague to Meissen hourly. Tickets cost $8 - $14 and the journey takes 1 h 55 min. 4 other operators also service this route. Alternatively, Czech Railways (ČD) operates a train from Prague to Meissen every 2 hours. Tickets cost $20 - $30 and the journey takes 2 h 15 min. S-Bahn also services this route every 30 minutes.
From Prague, Prague ÚAN Florenc bus to Dresden Hbf then train to Meißen Altstadt. 2 h 42 min 18€. From Praha hl.n. train to Dresden Hbf then train to Meißen Altstadt. 3 h 2 min 25€. From Prague drive to Meissen. 1 h 46 min 22€.