There are 9 ways to get from Prague to Isernia by plane, train, train (Trenitalia), bus, night train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Naples Airport, train
best- Fly from Václav Havel Airport Prague (PRG) to Naples Airport (NAP)plane PRG - NAP
- Take the train from Napoli Centrale to Iserniatrain
7h 47m€61–192Fly to Fiumicino International Airport, train
cheapest- Fly from Václav Havel Airport Prague (PRG) to Fiumicino International Airport (FCO)plane PRG - FCO
- Take the train from Roma Termini to Iserniatrain
8h 2m€51–169Train
- Take the train from Praha Hlavni Nadrazi to Muenchen Hbftrain Ec
- Take the train from München Hbf to Verona Porta Nuovatrain 89
- Take the train from Verona Porta Nuova to Roma Terminitrain Fr
- Take the train from Roma Termini to Iserniatrain Re
19h 43m€187–334Bus via Munich
- Take the bus from Prague - Florenc Main Bus Terminal to Munich - Bus Stationbus
- Take the bus from Munich to Termolibus
- Take the bus from Termoli Terminal Bus to Iserniabus
20h 28m€96–123Train, night train
- Take the train from Praha Hlavni Nadrazi to Wien Hbftrain Rj
- Take the night train from Wien Hbf to Roma Tiburtinanighttrain Nj
- Take the train from Roma Tiburtina to Iserniatrain Re
22h 26m€112–340Fly to Roma Ciampino Airport, train
- Fly from Václav Havel Airport Prague (PRG) to Roma Ciampino Airport (CIA)plane PRG - CIA
- Take the train from Ciampino to Iserniatrain
7h 58m€66–241Bus
- Take the bus from Praha, Hlavní Nádraží to Roma, Autostazione Tiburtinabus N1533
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
24h 10m€64–167Drive, car train
- Drive from Prague to Salzburg Hbfcar
- Take the car train from Salzburg Hbf to Villach Hbfcartrain
- Drive from Villach Hbf to Iserniacar
15h 22m€262–376Drive 1,291 km
- Drive from Prague to Iserniacar 1,291 km
16h 6m€200–288
Prague to Isernia by train
Questions & Answers
The cheapest way to get from Prague to Isernia is to fly and train which costs €50 - €170 and takes 8h 2m.
The fastest way to get from Prague to Isernia is to fly and train which takes 7h 47m and costs €60 - €200.
No, there is no direct bus from Prague to Isernia. However, there are services departing from Prague - Florenc Main Bus Terminal and arriving at Isernia via Munich and Termoli Terminal Bus. The journey, including transfers, takes approximately 20h 28m.
No, there is no direct train from Prague to Isernia. However, there are services departing from Praha Hlavni Nadrazi and arriving at Isernia via München Hbf, Verona Porta Nuova and Roma Termini. The journey, including transfers, takes approximately 19h 43m.
The distance between Prague and Isernia is 1171 km. The road distance is 1291 km.
The best way to get from Prague to Isernia without a car is to train which takes 19h 43m and costs €180 - €340.
It takes approximately 7h 47m to get from Prague to Isernia, including transfers.
Prague to Isernia bus services, operated by FlixBus, depart from Praha, Hlavní Nádraží station.
Prague to Isernia train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
The best way to get from Prague to Isernia is to train which takes 19h 43m and costs €180 - €340. Alternatively, you can bus via Munich, which costs €95 - €130 and takes 20h 28m.
What companies run services between Prague, Czechia and Isernia, Italy?
You can take a train from Praha Hlavni Nadrazi to Isernia via Muenchen Hbf, München Hbf, Verona Porta Nuova, and Roma Termini in around 19h 43m. Alternatively, you can take a bus from Prague - Florenc Main Bus Terminal to Isernia via Munich - Bus Station, Munich, and Termoli Terminal Bus in around 20h 28m.
- Website
- ryanair.com
Flights from Václav Havel Airport Prague to Naples Airport
- Ave. Duration
- 2h
- When
- Monday, Tuesday, Thursday, Saturday, and Sunday
- Estimated price
- €55–170
Flights from Václav Havel Airport Prague to Roma Ciampino Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- €50–210
- Website
- lufthansa.com
Flights from Václav Havel Airport Prague to Naples Airport via Munich
- Ave. Duration
- 3h 40m
- When
- Thursday, Friday, and Sunday
- Estimated price
- €45–280
Flights from Václav Havel Airport Prague to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- €65–260
- Website
- flyulendo.com
Flights from Václav Havel Airport Prague to Fiumicino International Airport
- Ave. Duration
- 1h 55m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €28–110
- Website
- neosair.it
Flights from Václav Havel Airport Prague to Fiumicino International Airport
- Ave. Duration
- 1h 45m
- When
- Saturday and Sunday
- Estimated price
- €130–470
- Website
- easyjet.com
Flights from Václav Havel Airport Prague to Naples Airport
- Ave. Duration
- 1h 55m
- When
- Friday and Sunday
- Estimated price
- €40–140
- Website
- smartwings.com
Flights from Václav Havel Airport Prague to Fiumicino International Airport
- Ave. Duration
- 1h 55m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €50–120
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €14
- Website
- https://www.trenitalia.com/en.html
Train from Ciampino to Isernia
- Ave. Duration
- 2h 6m
- Frequency
- Once a week
- Estimated price
- €13–15
- Website
- https://www.trenitalia.com/en.html
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Praha Hlavni Nadrazi to Muenchen Hbf
- Ave. Duration
- 5h 43m
- Frequency
- Every 4 hours
- Estimated price
- €75–100
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from München Hbf to Verona Porta Nuova
- Ave. Duration
- 5h 29m
- Frequency
- Every 4 hours
- Estimated price
- €65–120
- Website
- https://int.bahn.de/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Verona Porta Nuova to Roma Termini
- Ave. Duration
- 3h 23m
- Frequency
- Every 4 hours
- Estimated price
- €35–100
- Schedules at
- trenitalia.com
- Phone
- +420 221 111 122
- info@cd.cz
- Website
- cd.cz
Train from Praha Hlavni Nadrazi to Wien Hbf
- Ave. Duration
- 4h 12m
- Frequency
- Every 4 hours
- Estimated price
- €18–50
- Website
- https://www.cd.cz/en/default.htm
- Phone
- +420 222 222 221
- info@regiojet.cz
- Website
- regiojet.com
Train from Praha Hlavni Nadrazi to Wien Hbf
- Ave. Duration
- 4h 17m
- Frequency
- 4 times a day
- Estimated price
- €12–40
- Website
- https://regiojet.com/
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Wien Hbf to Roma Tiburtina
- Ave. Duration
- 14h
- Frequency
- Once daily
- Estimated price
- €85–280
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–280
- Couchette Carriage
- €160–190
- Seating Carriage
- €85–110
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Salzburg Hbf to Villach Hbf
- Ave. Duration
- 1h 29m
- Frequency
- Once daily
- Estimated price
- €90–110
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Prague - Florenc Main Bus Terminal to Munich - Bus Station
- Ave. Duration
- 5h 50m
- Frequency
- 4 times a week
- Estimated price
- €16–25
- Website
- https://www.blablacar.co.uk/bus
- Phone
- +39 098 3520 315
- info@fsbusitaliafast.it
- Website
- simetbus.it
Bus from Munich to Termoli
- Ave. Duration
- 11h 3m
- Frequency
- Once a week
- Estimated price
- €75–90
- Schedules at
- simetbus.it
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Termoli Terminal Bus to Isernia
- Ave. Duration
- 1h 35m
- Frequency
- Once a week
- Estimated price
- €5–8
- Schedules at
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Praha, Hlavní Nádraží to Roma, Autostazione Tiburtina
- Ave. Duration
- 21h
- Frequency
- Once daily
- Estimated price
- €55–140
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €8–35
- Website
- https://www.flixbus.co.uk
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More Questions & Answers
Prague to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Prague to Isernia train services, operated by ÖBB EuroCity, arrive at Muenchen Hbf station.
Yes, the driving distance between Prague to Isernia is 1291 km. It takes approximately 16h 6m to drive from Prague to Isernia.
Book your Prague to Isernia bus tickets online with Omio and FlixBus.
There are 421+ hotels available in Isernia.















































