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How to get fromPrague to Iserniaby plane, train, train (Trenitalia), bus, night train, car or car train

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There are 9 ways to get from Prague to Isernia by plane, train, train (Trenitalia), bus, night train, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Naples Airport, train

    best
    1. Fly from Václav Havel Airport Prague (PRG) to Naples Airport (NAP)plane plane PRG - NAP
    2. Take the train from Napoli Centrale to Iserniatrain train
    7h 47m
    €61–192
  2. Fly to Fiumicino International Airport, train

    cheapest
    1. Fly from Václav Havel Airport Prague (PRG) to Fiumicino International Airport (FCO)plane plane PRG - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    8h 2m
    €51–169
  3. Train

    1. Take the train from Praha Hlavni Nadrazi to Muenchen Hbftrain train Ec
    2. Take the train from München Hbf to Verona Porta Nuovatrain train 89
    3. Take the train from Verona Porta Nuova to Roma Terminitrain train Fr
    4. Take the train from Roma Termini to Iserniatrain train Re
    19h 43m
    €187–334
  4. Bus via Munich

    1. Take the bus from Prague - Florenc Main Bus Terminal to Munich - Bus Stationbus bus
    2. Take the bus from Munich to Termolibus bus
    3. Take the bus from Termoli Terminal Bus to Iserniabus bus
    20h 28m
    €96–123
  5. Train, night train

    1. Take the train from Praha Hlavni Nadrazi to Wien Hbftrain train Rj
    2. Take the night train from Wien Hbf to Roma Tiburtinanighttrain night train Nj
    3. Take the train from Roma Tiburtina to Iserniatrain train Re
    22h 26m
    €112–340
  6. Fly to Roma Ciampino Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Roma Ciampino Airport (CIA)plane plane PRG - CIA
    2. Take the train from Ciampino to Iserniatrain train
    7h 58m
    €66–241
  7. Bus

    1. Take the bus from Praha, Hlavní Nádraží to Roma, Autostazione Tiburtinabus bus N1533
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    24h 10m
    €64–167
  8. Drive, car train

    1. Drive from Prague to Salzburg Hbfcar car
    2. Take the car train from Salzburg Hbf to Villach Hbfcartrain train
    3. Drive from Villach Hbf to Iserniacar car
    15h 22m
    €262–376
  9. Drive 1,291 km

    1. Drive from Prague to Iserniacar car 1,291 km
    16h 6m
    €200–288

Prague to Isernia by train

Calendar35Weekly Trains
Duration19h 43mAverage Duration
Ticket€187Cheapest Price
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Questions & Answers

What companies run services between Prague, Czechia and Isernia, Italy?

You can take a train from Praha Hlavni Nadrazi to Isernia via Muenchen Hbf, München Hbf, Verona Porta Nuova, and Roma Termini in around 19h 43m. Alternatively, you can take a bus from Prague - Florenc Main Bus Terminal to Isernia via Munich - Bus Station, Munich, and Termoli Terminal Bus in around 20h 28m.

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