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How to get fromPrague to Iserniaby plane, train, train (Trenitalia), bus, night train, or car

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There are 9 ways to get from Prague to Isernia by plane, train, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fiumicino International Airport, train

    best
    1. Fly from Václav Havel Airport Prague (PRG) to Fiumicino International Airport (FCO)plane plane PRG - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    8h 7m
    €57–181

  2. Train

    1. Take the train from Praha Hlavni Nadrazi to Wien Hbftrain train Rj
    2. Take the train from Wien Hbf to Venezia Mestretrain train Rjx
    3. Take the train from Venezia Mestre to Roma Terminitrain train Fr
    4. Take the train from Roma Termini to Iserniatrain train Re
    19h 29m
    €187–401

  3. Bus

    1. Take the bus from Prague Florenc Central Bus Station to Rome Tiburtina Bus Stationbus bus : Prague Central Bus Station - Rome Tiburtina Bus Station / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    23h 25m
    €119–179

  4. Train, night train

    1. Take the train from Praha Hlavni Nadrazi to Wien Hbftrain train Rj
    2. Take the night train from Wien Hbf to Roma Tiburtinanighttrain night train Nj
    3. Take the train from Roma Termini to Iserniatrain train Re
    22h 42m
    €108–263

  5. Fly to Roma Ciampino Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Roma Ciampino Airport (CIA)plane plane PRG - CIA
    2. Take the train from Ciampino to Iserniatrain train
    7h 52m
    €69–241

  6. Fly to Naples Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Naples Airport (NAP)plane plane PRG - NAP
    2. Take the train from Caserta to Iserniatrain train
    8h 10m
    €65–217

  7. Fly to Abruzzo Airport, bus

    1. Fly from Václav Havel Airport Prague (PRG) to Abruzzo Airport (PSR)plane plane PRG - PSR
    2. Take the bus from Pescara to Iserniabus bus
    9h 13m
    €65–218

  8. Bus via Prague, Central Train Station

    1. Take the bus from Praha, Hlavní Nádraží to Roma, Autostazione Tiburtinabus bus N1533
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    24h 10m
    €131–228

  9. Drive 1,291.1 km

    1. Drive from Prague to Iserniacar car 1,291.1 km
    16h 7m
    €202–292

Prague to Isernia by train

Calendar28Weekly Trains
Duration19h 29mAverage Duration
Ticket€187Cheapest Price
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Questions & Answers

Map of how to get from Prague to Isernia.ExpandLaunch map view
  • Distance: 1,169 km
  • Duration: 8h 7m

What companies run services between Prague, Czechia and Isernia, Italy?

You can take a train from Praha Hlavni Nadrazi to Isernia via Wien Hbf, Venezia Mestre, and Roma Termini in around 19h 29m. Alternatively, you can take a bus from Prague Florenc Central Bus Station to Isernia via Roma, Autostazione Tiburtina in around 23h 25m.

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