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How to get fromPoughkeepsie to Williamsvilleby train (Amtrak), car, train, plane or bus

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There are 6 ways to get from Poughkeepsie to Williamsville by train (Amtrak), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Poughkeepsie Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    6h 43m
    $71–159

  2. Drive 327.1 mi

    cheapest
    1. Drive from Poughkeepsie to Williamsvillecar car 327.1 mi
    6h 34m
    $60–87

  3. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    4h 50m
    $142–850

  4. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    5h 13m
    $144–762

  5. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    5h 44m
    $137–913

  6. Train to Laguardia Airport, fly to Rochester, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    3. Take the bus from Rochester, NY to Buffalo, NYbus bus
    6h 51m
    $303–705

Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF) flights

Calendar44Weekly Planes
Duration1h 29mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Williamsville, NY, USA?

Amtrak operates a train from Poughkeepsie Amtrak Station to Buffalo Depew Station 4 times a day. Tickets cost $50–140 and the journey takes 6h 34m. VIA Rail also services this route once daily.

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