From Poughkeepsie train to Grand Central. 1 h 52 min $24. From Poughkeepsie bus to New York, Ny. 2 h 22 min $25. From Poughkeepsie - Academy Street & Cannon Street bus to Poughkeepsie Amtrak then train to New York Penn Station. 2 h 40 min $39. From Poughkeepsie drive to Times Square. 1 h 33 min $9.
Metro-North Railroad (MNR) operates a train from Poughkeepsie to Times Square hourly. Tickets cost $17 - $35 and the journey takes 1 h 52 min. Alternatively, Coach USA operates a bus from Poughkeepsie to Times Square twice daily. Tickets cost $22 - $35 and the journey takes 2 h 22 min.