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How to get fromPoughkeepsie to St. Louisby train, plane, train (Amtrak), bus, or car

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There are 8 ways to get from Poughkeepsie to St. Louis by train, plane, train (Amtrak), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    6h 32m
    $164–479

  2. Train to John F. Kennedy International Airport, fly

    cheapest
    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    7h 12m
    $146–650

  3. Train (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    23h 48m
    $291–676

  4. Train, bus

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train Hudson
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    26h 7m
    $182–297

  5. Drive  994.8 mi

    1. Drive from Poughkeepsie to St. Louiscar car 994.8 mi
    16h 52m
    $182–263

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    6h 30m
    $332–973

  7. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    7h 48m
    $163–1,399

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Lambert–St. Louis International Airport (STL)plane plane HPN - STL
    10h 33m
    $232–1,148

Poughkeepsie to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration23h 48mAverage Duration
Ticket$291Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poughkeepsie to St. Louis.ExpandLaunch map view
  • Distance: 975.8 mi
  • Duration: 6h 32m

What companies run services between Poughkeepsie, NY, USA and St. Louis, MO, USA?

You can take a train from Poughkeepsie Amtrak Station to St. Louis via Chicago Union Station in around 23h 48m.

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