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How to get fromPoughkeepsie to St. Louisby train, plane, train (Amtrak), bus or car

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There are 8 ways to get from Poughkeepsie to St. Louis by train, plane, train (Amtrak), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    6h 55m
    $222–486

  2. Train, bus

    cheapest
    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train Hudson
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    25h 57m
    $105–294

  3. Train (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    23h 48m
    $169–557

  4. Drive 994.8 mi

    1. Drive from Poughkeepsie to St. Louiscar car 994.8 mi
    16h 48m
    $182–263

  5. Train to John F. Kennedy International Airport, fly

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    7h 1m
    $154–698

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    7h 48m
    $182–714

  7. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    8h 15m
    $243–1,164

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Lambert–St. Louis International Airport (STL)plane plane HPN - STL
    10h 53m
    $181–846

Poughkeepsie to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration23h 48mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and St. Louis, MO, USA?

You can take a train from Poughkeepsie Amtrak Station to St. Louis via Chicago Union Station in around 23h 48m.

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