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How to get fromPoughkeepsie to St. Louisby train, plane, train (Amtrak), bus or car

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There are 8 ways to get from Poughkeepsie to St. Louis by train, plane, train (Amtrak), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)planeLGA - STL
    6h 44m
    $192–486

  2. Train, bus

    cheapest
    1. Take the train from Poughkeepsie to Grand Central TerminaltrainHudson
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus StationbusGreyhound US0421
    25h 57m
    $105–254

  3. Train (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union StationtrainLake Shore Limited
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    23h 48m
    $140–638

  4. Drive 994.6 mi

    1. Drive from Poughkeepsie to St. Louiscar994.6 mi
    16h 39m
    $182–263

  5. Train to John F. Kennedy International Airport, fly

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain
    2. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)planeJFK - STL
    7h 16m
    $134–598

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)planeEWR - STL
    7h 31m
    $166–725

  7. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain
    3. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)planePHL - STL
    8h 10m
    $217–1,145

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Westchester County Airport (HPN) to Lambert–St. Louis International Airport (STL)planeHPN - STL
    11h 5m
    $201–896

Poughkeepsie to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration23h 48mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and St. Louis, MO, USA?

You can take a train from Poughkeepsie Amtrak Station to St. Louis via Chicago Union Station in around 23h 48m.

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