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How to get fromPoughkeepsie to Des Moinesby train, plane, bus, bus (Flixbus) or car

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There are 10 ways to get from Poughkeepsie to Des Moines by train, plane, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Laguardia Airport (LGA) to Des Moines (DSM)planeLGA - DSM
    6h 46m
    $196–854

  2. Train, bus

    cheapest
    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union StationtrainLake Shore Limited
    2. Take the bus from Chicago Bus Station to Des MoinesbusGreyhound US0123 / ...
    25h 45m
    $145–369

  3. Bus

    1. Take the bus from Rosendale, Ny to Port Authority Bus Terminalbus291
    2. Take the bus from New York Midtown to Chicago Bus Stationbus
    3. Take the bus from Chicago to Des Moinesbus
    33h 48m
    $172–415

  4. Drive 1,127.9 mi

    1. Drive from Poughkeepsie to Des Moinescar1,127.9 mi
    18h 35m
    $206–298

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Fly from Newark Liberty International Airport (EWR) to Des Moines (DSM)planeEWR - DSM
    7h 15m
    $190–1,033

  6. Train to Albany County Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Albany-Rensselaer Amtrak Stationtrain
    2. Fly from Albany County Airport (ALB) to Des Moines (DSM)planeALB - DSM
    8h 42m
    $275–1,303

  7. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain
    3. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)planePHL - DSM
    7h 58m
    $231–1,593

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Westchester County Airport (HPN) to Des Moines (DSM)planeHPN - DSM
    10h 50m
    $275–1,264

  9. Train, bus via Des Moines

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union StationtrainLake Shore Limited
    2. Take the bus from Chicago to Des MoinesbusChicago
    26h 21m
    $155–439

  10. Train, bus via Galesburg

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain
    3. Take the bus from Galesburg to Burlingtonbus
    4. Take the bus from Burlington to Des Moinesbus
    27h 53m
    $192–494

Poughkeepsie to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration25h 45mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Des Moines, IA, USA?

You can take a bus from Poughkeepsie Main & Market to Des Moines via Rt 32 & Henry Dubois Dr, Rosendale Park & Ride, Rosendale, Ny, Port Authority Bus Terminal, New York Midtown, and Chicago in around 33h 48m.

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