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How to get fromPoughkeepsie to Des Moinesby train, plane, bus, bus (Flixbus) or car

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There are 10 ways to get from Poughkeepsie to Des Moines by train, plane, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Des Moines (DSM)plane plane LGA - DSM
    6h 47m
    $216–954

  2. Train, bus

    cheapest
    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123 / ...
    25h 45m
    $123–433

  3. Bus

    1. Take the bus from Rosendale, Ny to Port Authority Bus Terminalbus bus 291
    2. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Des Moinesbus bus
    33h 48m
    $167–445

  4. Drive 1,127.9 mi

    1. Drive from Poughkeepsie to Des Moinescar car 1,127.9 mi
    18h 35m
    $206–298

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Des Moines (DSM)plane plane EWR - DSM
    7h 15m
    $196–1,082

  6. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    7h 53m
    $247–1,642

  7. Train to Albany County Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Albany-Rensselaer Amtrak Stationtrain train
    2. Fly from Albany County Airport (ALB) to Des Moines (DSM)plane plane ALB - DSM
    9h 25m
    $266–1,304

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Des Moines (DSM)plane plane HPN - DSM
    10h 44m
    $245–1,064

  9. Train, bus via Des Moines

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago to Des Moinesbus bus Chicago
    26h 21m
    $133–498

  10. Train, bus via Galesburg

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Burlingtonbus bus
    4. Take the bus from Burlington to Des Moinesbus bus
    27h 53m
    $173–553

Poughkeepsie to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration25h 45mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Des Moines, IA, USA?

You can take a bus from Poughkeepsie Main & Market to Des Moines via Rt 32 & Henry Dubois Dr, Rosendale Park & Ride, Rosendale, Ny, Port Authority Bus Terminal, New York Midtown, and Chicago in around 33h 48m.

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