Rome2Rio

How to get fromPoughkeepsie to Des Moinesby train, plane, bus, bus (Flixbus, Greyhound) or car

Find Transport to Des Moines

See all options

There are 8 ways to get from Poughkeepsie to Des Moines by train, plane, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Des Moines (DSM)plane plane LGA - DSM
    6h 47m
    $226–1,054

  2. Bus

    cheapest
    1. Take the bus from Newburgh ShortLine Transportation Center to Port Authority Bus Terminalbus bus
    2. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    33h 10m
    $158–376

  3. Train, bus

    1. Take the train from Poughkeepsie Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123 / ...
    25h 45m
    $160–418

  4. Drive 1,127.9 mi

    1. Drive from Poughkeepsie to Des Moinescar car 1,127.9 mi
    18h 47m
    $206–298

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Des Moines (DSM)plane plane EWR - DSM
    7h 20m
    $206–1,118

  6. Train, train to Philadelphia International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    7h 53m
    $247–1,678

  7. Train to Albany County Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Albany-Rensselaer Amtrak Stationtrain train
    2. Fly from Albany County Airport (ALB) to Des Moines (DSM)plane plane ALB - DSM
    8h 52m
    $256–1,305

  8. Train to Westchester County Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Des Moines (DSM)plane plane HPN - DSM
    10h 43m
    $235–1,064

Poughkeepsie to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration25h 45mAverage Duration
Ticket$160Cheapest Price
See schedules

Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Des Moines, IA, USA?

You can take a train from Poughkeepsie to Des Moines via Beacon, Beacon Station, Newburgh ShortLine Transportation Center, Port Authority Bus Terminal, 9 Av/W 40 St, 9 Av/W 34 St, New York Midtown, and Chicago Bus Station in around 33h 10m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Poughkeepsie

Trips to Des Moines

Popular routes