There are 8 ways to get from Poughkeepsie to Buffalo–Depew Station by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  6 h 26 min

  1. Take the train from Poughkeepsie to Buffalo VIA Rail / ...

$50 - $180

7 alternative options

Bus  •  11 h 52 min

  1. Take the bus from Poughkeepsie, NY to Binghamton Poughkeepsie-Binghampton
  2. Take the bus from Binghamton, Ny to Buffalo, Ny 252 / ...

$65 - $118

Drive  •  6 h 10 min

  1. Drive from Poughkeepsie to Buffalo–Depew Station 358.8 miles

$35 - $55

Train to New York JFK, fly to Buffalo  •  6 h 17 min

  1. Take the train from Poughkeepsie to New York
  2. Fly from New York JFK (JFK) to Buffalo (BUF) JFK - BUF

$99 - $442

Train to New York La Guardia, fly to Buffalo  •  6 h 19 min

  1. Take the train from Poughkeepsie to New York
  2. Fly from New York La Guardia (LGA) to Buffalo (BUF) LGA - BUF

$97 - $445

Train to Newark, fly to Buffalo  •  6 h 18 min

  1. Take the train from Poughkeepsie to New York
  2. Fly from Newark (EWR) to Buffalo (BUF) EWR - BUF

$133 - $553

Train to Newark, fly to Rochester, train  •  7 h 22 min

  1. Take the train from Poughkeepsie to New York
  2. Fly from Newark (EWR) to Rochester (ROC) EWR - ROC
  3. Take the train from Rochester to Buffalo

$156 - $602

Train to New York La Guardia, fly to Rochester, train  •  7 h 25 min

  1. Take the train from Poughkeepsie to New York
  2. Fly from New York La Guardia (LGA) to Rochester (ROC) LGA - ROC
  3. Take the train from Rochester to Buffalo

$145 - $554

Questions & Answers

No, there is no direct bus from Poughkeepsie to Buffalo–Depew Station station. However, there are services departing from Poughkeepsie, NY and arriving at Amtrak Station & Dick Rd via Binghamton, Ny, Ellicott St & North Division St and Walden Ave & Thruway Transit Center. The journey, including transfers, takes approximately 11 h 52 min.

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Yes, there is a direct train departing from Poughkeepsie and arriving at Buffalo. Services depart hourly, and operate every day. The journey takes approximately 6 h 26 min.

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The distance between Poughkeepsie and Buffalo–Depew Station is 261 miles. The road distance is 358.8 miles.

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The best way to get from Poughkeepsie to Buffalo–Depew Station without a car is to train which takes 6 h 26 min and costs .

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The train from Poughkeepsie to Buffalo takes 6 h 26 min including transfers and departs hourly.

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Poughkeepsie to Buffalo–Depew Station bus services, operated by Coach USA, depart from Poughkeepsie, NY station.

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Poughkeepsie to Buffalo–Depew Station train services, operated by VIA Rail, depart from Poughkeepsie station.

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The best way to get from Poughkeepsie to Buffalo–Depew Station is to train which takes 6 h 26 min and costs . Alternatively, you can bus, which costs and takes 11 h 52 min.

Mode details

The quickest flight from New York JFK Airport to Buffalo Airport is the direct flight which takes 1 h 16 min.

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Poughkeepsie to Buffalo–Depew Station bus services, operated by Greyhound USA, arrive at Buffalo, Ny station.

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Map of how to get from Poughkeepsie to Buffalo–Depew Station.
Launch map view
  • Distance: 260.8 miles
  • Duration: 6 h 26 min

What companies run services between Poughkeepsie, NY, USA and Buffalo–Depew Station, NY, USA?

VIA Rail operates a train from Poughkeepsie to Buffalo–Depew Station every 3 hours. Tickets cost $50 - $180 and the journey takes 6 h 26 min. Amtrak also services this route 3 times a day. Alternatively, you can take a bus from Poughkeepsie to Buffalo–Depew Station via Binghamton, Binghamton, Ny, Buffalo, Ny, Ellicott St & North Division St, and Walden Ave & Thruway Transit Center in around 11 h 52 min.

Airlines
United Airlines
Website
united.com
Flights from New York La Guardia to Buffalo via Washington Dulles
Ave. Duration
3 h 37 min
When
Every day
Estimated price
$220 - $1,600
Flights from Newark to Buffalo
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$120 - $850
Flights from Newark to Buffalo via Washington Dulles
Ave. Duration
3 h 28 min
When
Every day
Estimated price
$120 - $850
Flights from Newark to Rochester
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$120 - $600
Delta
Website
delta.com
Flights from New York JFK to Buffalo
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$90 - $650
Flights from New York La Guardia to Buffalo
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$100 - $700
Flights from New York La Guardia to Rochester
Ave. Duration
1 h 23 min
When
Every day
Estimated price
$90 - $600
JetBlue Airways
Website
jetblue.com
Flights from New York JFK to Buffalo
Ave. Duration
1 h 23 min
When
Every day
Estimated price
$100 - $650
American Airlines
Website
aa.com
Flights from New York La Guardia to Buffalo via Reagan Washington
Ave. Duration
3 h 39 min
When
Monday to Friday
Estimated price
$130 - $800
Air Canada
Website
aircanada.com
Flights from New York La Guardia to Rochester via Toronto
Ave. Duration
3 h 29 min
When
Every day
Estimated price
$160 - $700
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Poughkeepsie to Buffalo
Ave. Duration
6 h 26 min
Frequency
Every 3 hours
Estimated price
$50 - $180
Website
viarail.ca
Escape
$50 - $75
Economy
$85 - $120
Economy Plus
$120 - $180
Business
$120 - $180
Business Plus/Sleeper
$230 - $320
Train from Poughkeepsie to New York
Ave. Duration
1 h 35 min
Frequency
Every 3 hours
Estimated price
$25 - $75
Website
viarail.ca
Escape
$25 - $35
Economy
$30 - $45
Economy Plus
$50 - $75
Business
$45 - $65
Business Plus/Sleeper
$85 - $120
Train from Rochester to Buffalo
Ave. Duration
1 h 9 min
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$45 - $70
Business
$40 - $60
Business Plus/Sleeper
$75 - $110
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Poughkeepsie Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
6 h 16 min
Frequency
3 times a day
Estimated price
$60 - $160
Website
amtrak.com
Coach Seat
$60 - $90
Flexi Coach Seat
$100 - $150
Business Coach Seat
$110 - $160
Room
$260 - $370
Train from Poughkeepsie Amtrak to New York Penn Station
Ave. Duration
1 h 33 min
Frequency
Every 4 hours
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Rochester Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
1 h
Frequency
5 times a day
Estimated price
$25 - $50
Website
amtrak.com
Coach Seat
$25 - $40
Flexi Coach Seat
$45 - $65
Business Coach Seat
$35 - $50
Room
$140 - $200
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Binghamton, Ny to Buffalo, Ny
Ave. Duration
5 h 5 min
Frequency
Every 30 minutes
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70

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More Questions & Answers

Poughkeepsie to Buffalo–Depew Station train services, operated by VIA Rail, arrive at Buffalo station.

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Yes, the driving distance between Poughkeepsie to Buffalo–Depew Station is 359 miles. It takes approximately 6 h 10 min to drive from Poughkeepsie to Buffalo–Depew Station.

Get driving directions

Delta and JetBlue Airways offer flights from New York JFK Airport to Buffalo Airport.

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Book your Poughkeepsie to Buffalo–Depew Station train tickets online with Rome2rio.

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There are 130+ hotels available in Buffalo–Depew Station. Prices start at $65 USD per night.

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