There are 8 ways to get from Poughkeepsie to Buffalo–Depew Station by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  6 h 22 min

  1. Take the train from Poughkeepsie to Buffalo VIA Rail / ...

$50 - $180

7 alternative options

Bus  •  11 h 54 min

  1. Take the bus from Poughkeepsie, NY to Binghamton Poughkeepsie-Binghampton
  2. Take the bus from Binghamton, Ny to Buffalo, Ny 252 / ...

$65 - $118

Drive  •  6 h 10 min

  1. Drive from Poughkeepsie to Buffalo–Depew Station 358.8 miles

$35 - $55

Train to Newark, fly to Buffalo  •  6 h 36 min

  1. Take the train from Poughkeepsie to Grand Central
  2. Fly from Newark (EWR) to Buffalo (BUF) EWR - BUF

$126 - $533

Train to New York JFK, fly to Buffalo  •  6 h 12 min

  1. Take the train from Poughkeepsie Amtrak to New York Penn Station
  2. Fly from New York JFK (JFK) to Buffalo (BUF) JFK - BUF

$100 - $423

Train to New York La Guardia, fly to Buffalo  •  6 h 20 min

  1. Take the train from Poughkeepsie Amtrak to New York Penn Station
  2. Fly from New York La Guardia (LGA) to Buffalo (BUF) LGA - BUF

$99 - $424

Train to Albany, fly to Buffalo  •  6 h 29 min

  1. Take the train from Poughkeepsie Amtrak to Albany-Rensselaer Amtrak
  2. Fly from Albany (ALB) to Buffalo (BUF) ALB - BUF

$75 - $428

Train to New York La Guardia, fly to Rochester, train  •  6 h 59 min

  1. Take the train from Poughkeepsie Amtrak to New York Penn Station
  2. Fly from New York La Guardia (LGA) to Rochester (ROC) LGA - ROC
  3. Take the train from Rochester Amtrak to Buffalo Depew Station Amtrak

$148 - $513

Questions & Answers

The cheapest way to get from Poughkeepsie to Buffalo–Depew Station is to drive which costs $35 - $55 and takes 6 h 10 min.

More details

The quickest way to get from Poughkeepsie to Buffalo–Depew Station is to drive which costs $35 - $55 and takes 6 h 10 min.

More details

The distance between Poughkeepsie and Buffalo–Depew Station is 261 miles. The road distance is 358.8 miles.

Get driving directions

The train from Poughkeepsie to Buffalo takes 6 h 22 min including transfers and departs hourly.

More details

No, there is no direct bus from Poughkeepsie to Buffalo–Depew Station. However, there are services departing from Poughkeepsie, NY and arriving at Walden Ave & 2929 Walden via Binghamton, Ny, Ellicott St & North Division St and Galleria Drway & Green Parking Entrance. The journey, including transfers, takes approximately 11 h 54 min.

More details

Yes, there is a direct train departing from Poughkeepsie and arriving at Buffalo. Services depart hourly, and operate every day. The journey takes approximately 6 h 22 min.

More details

What companies run services between Poughkeepsie, NY, USA and Buffalo–Depew Station, NY, USA?

VIA Rail operates a train from Poughkeepsie to Buffalo–Depew Station every 3 hours. Tickets cost $50 - $180 and the journey takes 6 h 22 min. Amtrak also services this route 4 times a day. Alternatively, you can take a bus from Poughkeepsie to Buffalo–Depew Station via Binghamton, Binghamton, Ny, Buffalo, Ny, Ellicott St & North Division St, Galleria Drway & Green Parking Entrance, and Walden Ave & 2929 Walden in around 11 h 54 min.

Airlines
Delta
Website
delta.com
Flights from New York JFK to Buffalo
Ave. Duration
1 h 44 min
When
Every day
Estimated price
$90 - $650
Flights from New York La Guardia to Buffalo
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$100 - $700
Flights from New York La Guardia to Buffalo via Boston
Ave. Duration
3 h 50 min
When
Monday to Friday
Estimated price
$100 - $700
Flights from New York La Guardia to Rochester
Ave. Duration
1 h 28 min
When
Every day
Estimated price
$90 - $600
United Airlines
Website
united.com
Flights from Newark to Buffalo
Ave. Duration
1 h 29 min
When
Every day
Estimated price
$120 - $850
Flights from Newark to Buffalo via Washington Dulles
Ave. Duration
3 h 34 min
When
Every day
Estimated price
$120 - $850
Flights from New York La Guardia to Buffalo via Washington Dulles
Ave. Duration
3 h 43 min
When
Monday to Saturday
Estimated price
$220 - $1,600
JetBlue Airways
Website
jetblue.com
Flights from Newark to Buffalo via Boston
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$160 - $1,200
Flights from New York JFK to Buffalo
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$100 - $650
American Airlines
Website
aa.com
Flights from New York La Guardia to Buffalo via Philadelphia
Ave. Duration
3 h 27 min
When
Saturday
Estimated price
$130 - $800
Flights from New York La Guardia to Buffalo via Reagan Washington
Ave. Duration
3 h 46 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$130 - $800
OneJet
Website
onejet.com
Flights from Albany to Buffalo
Ave. Duration
1 h
When
Monday to Friday
Estimated price
$45 - $370
Air Canada
Website
aircanada.com
Flights from New York La Guardia to Rochester via Toronto
Ave. Duration
3 h 29 min
When
Monday, Tuesday, Thursday, Friday, Saturday and Sunday
Estimated price
$160 - $700
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Poughkeepsie to Buffalo
Ave. Duration
6 h 22 min
Frequency
Every 3 hours
Estimated price
$50 - $180
Website
viarail.ca
Escape
$50 - $75
Economy
$85 - $120
Economy Plus
$120 - $180
Business
$120 - $180
Business Plus/Sleeper
$230 - $320
Train from Poughkeepsie to Grand Central Terminal
Ave. Duration
1 h 40 min
Frequency
Every 3 hours
Estimated price
$25 - $75
Website
viarail.ca
Escape
$25 - $35
Economy
$30 - $45
Economy Plus
$50 - $75
Business
$45 - $65
Business Plus/Sleeper
$85 - $120
Train from Poughkeepsie to Albany
Ave. Duration
1 h
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$50 - $70
Business
$45 - $65
Business Plus/Sleeper
$80 - $120
Train from Rochester to Buffalo
Ave. Duration
1 h 4 min
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$45 - $70
Business
$40 - $60
Business Plus/Sleeper
$75 - $110
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Poughkeepsie Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
6 h 16 min
Frequency
4 times a day
Estimated price
$60 - $160
Website
amtrak.com
Coach Seat
$60 - $90
Flexi Coach Seat
$100 - $150
Business Coach Seat
$110 - $160
Room
$260 - $370
Train from Poughkeepsie Amtrak to New York
Ave. Duration
1 h 38 min
Frequency
Every 3 hours
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$150 - $210
Train from Poughkeepsie Amtrak to New York Penn Station
Ave. Duration
1 h 33 min
Frequency
Every 3 hours
Estimated price
$27 - $50
Website
amtrak.com
Coach Seat
$27 - $50
Business Seat
$65
Train from Poughkeepsie Amtrak to Albany-Rensselaer Amtrak
Ave. Duration
1 h 5 min
Frequency
Hourly
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Rochester Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
46 min
Frequency
Every 4 hours
Estimated price
$25 - $50
Website
amtrak.com
Coach Seat
$25 - $40
Flexi Coach Seat
$45 - $65
Business Coach Seat
$35 - $50
Room
$140 - $200
Metro-North Railroad (MNR)
Website
mta.info
Train from Poughkeepsie to Grand Central
Ave. Duration
1 h 47 min
Frequency
Hourly
Estimated price
$17 - $35
Schedules at
mta.info
Off-peak at station
$17 - $19
Off-peak onboard
$23 - $25
Onboard
$25 - $35
At station
$24 - $27
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Binghamton, Ny to Buffalo, Ny
Ave. Duration
5 h 5 min
Frequency
Hourly
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70
Trailways New York
Website
trailwaysny.com
Bus from Binghamton to Buffalo, NY
Ave. Duration
4 h 45 min
Frequency
Once daily
Estimated price
$35 - $65
Schedules at
trailwaysny.com
Book at
trailwaysny.com

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