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How to get fromPortland to Mayo Clinicby plane, bus (Flixbus), train, bus or car

Find Transport to Mayo Clinic

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There are 5 ways to get from Portland to Mayo Clinic by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Portland International Airport (PDX) to Rochester (RST)plane plane PDX - RST
    9h 33m
    $304–1,543

  2. Bus

    cheapest
    1. Take the bus from Portland Curbside Bus Stop to Spokane Stationbus bus
    2. Take the bus from Spokane to Billingsbus bus
    3. Take the bus from Billings to Dickinsonbus bus
    4. Take the bus from Dickinson to Minneapolisbus bus
    5. Take the bus from Minneapolis to Rochesterbus bus
    39h 28m
    $193–674

  3. Train, bus

    1. Take the train from Portland to St. Paul-Minneapolistrain train Empire Builder
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson 965
    40h 21m
    $545–1,206

  4. Drive 1,752.1 mi

    1. Drive from Portland to Mayo Cliniccar car 1,752.1 mi
    28h 40m
    $320–462

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland International Airport (PDX) to Minneapolis–Saint Paul International Airport (MSP)plane plane PDX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 39m
    $255–1,057

Portland to Mayo Clinic by bus and foot

Calendar4Weekly Services
Duration39h 28mAverage Duration
Ticket$193Cheapest Price
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Questions & Answers

What companies run services between Portland, OR, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Portland International Airport (PDX) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Portland Curbside Bus Stop to Mayo Clinic via Spokane, Billings, Dickinson, Minneapolis, and Rochester in around 39h 28m.

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