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How to get fromPortland to Mayo Clinicby plane, bus (Flixbus), train, bus, or car

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There are 5 ways to get from Portland to Mayo Clinic by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Portland International Airport (PDX) to Rochester (RST)plane plane PDX - RST
    8h 13m
    $114–543

  2. Bus

    1. Take the bus from Portland Curbside Bus Stop to Pasco Bus Stopbus bus
    2. Take the bus from Pasco Bus Stop to Spokane Stationbus bus
    3. Take the bus from Spokane to Billingsbus bus
    4. Take the bus from Billings to Minneapolisbus bus
    5. Take the bus from Minneapolis to Rochesterbus bus
    37h 18m
    $385–581

  3. Train, bus

    1. Take the train from Portland to St. Paul-Minneapolistrain train Empire Builder
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    40h 21m
    $614–1,242

  4. Drive 1,767.8 mi

    1. Drive from Portland to Mayo Cliniccar car 1,767.8 mi
    27h 51m
    $323–466

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland International Airport (PDX) to Minneapolis–Saint Paul International Airport (MSP)plane plane PDX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 38m
    $235–495

Portland to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration37h 18mAverage Duration
Ticket$385Cheapest Price
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Questions & Answers

Map of how to get from Portland to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,493.1 mi
  • Duration: 8h 13m

What companies run services between Portland, OR, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Portland International Airport (PDX) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Portland Curbside Bus Stop to Mayo Clinic via Pasco Bus Stop, Spokane Station, Spokane, Billings, Minneapolis, and Rochester in around 37h 18m.

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