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How to get fromPortland to Mayo Clinicby plane, bus (Flixbus), train, bus or car

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There are 6 ways to get from Portland to Mayo Clinic by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland International Airport to Rochester

    best
    1. Fly from Portland International Airport (PDX) to Rochester (RST)plane plane PDX - RST
    8h 15m
    $144–743

  2. Train to Seattle-Tacoma International Airport, fly to Rochester

    cheapest
    1. Take the train from Portland to Tacomatrain train
    2. Fly from Seattle-Tacoma International Airport (SEA) to Rochester (RST)plane plane SEA - RST
    11h 15m
    $129–584

  3. Bus

    1. Take the bus from Portland Curbside Bus Stop to Pasco Bus Stopbus bus
    2. Take the bus from Pasco Bus Stop to Spokane Stationbus bus
    3. Take the bus from Spokane to Billingsbus bus
    4. Take the bus from Billings to Dickinsonbus bus
    5. Take the bus from Dickinson to Minneapolisbus bus
    6. Take the bus from Minneapolis to Rochesterbus bus
    37h 13m
    $184–664

  4. Train, bus

    1. Take the train from Portland to St. Paul-Minneapolistrain train Empire Builder
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson 965
    40h 21m
    $163–1,471

  5. Drive 1,752.1 mi

    1. Drive from Portland to Mayo Cliniccar car 1,752.1 mi
    28h 40m
    $320–462

  6. Fly Portland International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland International Airport (PDX) to Minneapolis–Saint Paul International Airport (MSP)plane plane PDX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 44m
    $224–976

Portland to Mayo Clinic by bus and foot

Calendar4Weekly Services
Duration37h 13mAverage Duration
Ticket$184Cheapest Price
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Questions & Answers

What companies run services between Portland, OR, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and three other airlines fly from Portland International Airport (PDX) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Portland Curbside Bus Stop to Mayo Clinic via Pasco Bus Stop, Spokane, Billings, Dickinson, Minneapolis, and Rochester in around 37h 13m.

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