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How to get fromPortland to Mayo ClinicBy plane, train, bus, or car

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There are 4 ways to get from Portland to Mayo Clinic by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Portland International Airport (PDX) to Rochester (RST)plane plane PDX - RST
    7h 50m
    $144–693

  2. Train, bus

    1. Take the train from Portland to St. Paul-Minneapolistrain train Empire Builder
    2. Take the bus from St. Paul to Rochester, MNbus bus Minneapolis / ...
    40h 26m
    $522–1,104

  3. Drive 1,767.8 mi

    1. Drive from Portland to Mayo Cliniccar car 1,767.8 mi
    27h 50m
    $323–466

  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland International Airport (PDX) to Minneapolis–Saint Paul International Airport (MSP)plane plane PDX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 41m
    $235–907

Portland to Mayo Clinic by train, bus, and foot

Calendar11Weekly Services
Duration40h 26mAverage Duration
Ticket$522Cheapest Price
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Questions & Answers

What companies run services between Portland, OR, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and two other airlines fly from Portland International Airport (PDX) to Rochester (RST) every 4 hours.

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