There are 10 ways to get from Portland to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Portland to Charlotte  •  4 h 19 min

  1. Fly from Portland (PWM) to Charlotte (CLT) PWM - CLT

$226 - $743

Cheapest option

Bus, Megabus  •  24 h 49 min

  1. Take the bus from Portland, ME to Logan Airport
  2. Take the bus from Boston, MA to New York, NY
  3. Take the Megabus from New York, NY to Fayetteville, NC
  4. Take the bus from Fayetteville, Nc to Florence, Sc

$87 - $174

8 alternative options

Fly Portland to Columbia  •  5 h 43 min

  1. Fly from Portland (PWM) to Columbia (CAE) PWM - CAE

$296 - $1,333

Fly Portland to Greenville/Spartanburg  •  5 h 36 min

  1. Fly from Portland (PWM) to Greenville/Spartanburg (GSP) PWM - GSP

$252 - $1,148

Fly Portland to Charleston  •  6 h 25 min

  1. Fly from Portland (PWM) to Charleston (CHS) PWM - CHS

$274 - $1,206

Bus to Boston, fly to Charleston  •  6 h 31 min

  1. Take the bus from Portland, ME to Logan Airport
  2. Fly from Boston (BOS) to Charleston (CHS) BOS - CHS

$142 - $491

Train to Manchester, fly to Charlotte  •  6 h 16 min

  1. Take the train from Portland Transportation Center Amtrak to Haverhill Amtrak
  2. Fly from Manchester (MHT) to Charlotte (CLT) MHT - CLT

$403 - $928

Bus, train  •  19 h 46 min

  1. Take the bus from Portland, Me to Boston, Ma
  2. Take the train from Boston South Station Amtrak to New York Penn Station
  3. Take the train from New York Penn Station to Florence Amtrak

$182 - $457

Bus  •  22 h 40 min

  1. Take the bus from Portland, Me to Boston, Ma
  2. Take the bus from Boston, MA - South Station to New York City, NY - Port Authority Bus Terminal
  3. Take the bus from New York, Ny to Fayetteville, Nc
  4. Take the bus from Fayetteville, Nc to Florence, Sc

$107 - $252

Drive  •  16 h 5 min

  1. Drive from Portland to Florence 952 miles

$90 - $140

Questions & Answers

The cheapest way to get from Portland to South Carolina is to drive which costs $90 - $140 and takes 16 h 5 min.

More details

The quickest way to get from Portland to South Carolina is to fly which costs $220 - $750 and takes 4 h 19 min.

More details

The distance between Portland and South Carolina is 885 miles. The road distance is 952 miles.

Get driving directions

It takes approximately 4 h 19 min to get from Portland to South Carolina, including transfers.

More details

No, there is no direct bus from Portland to South Carolina. However, there are services departing from Portland, Me and arriving at Florence, Sc via Boston, MA - South Station, New York, Ny and Fayetteville, Nc. The journey, including transfers, takes approximately 22 h 40 min.

More details

What companies run services between Portland, ME, USA and South Carolina, USA?

American Airlines, United Airlines and three other airlines fly from Portland to Rock Hill hourly. Alternatively, you can take a bus from Portland to Florence via Boston, Ma, Boston, MA - South Station, New York City, NY - Port Authority Bus Terminal, New York, Ny, and Fayetteville, Nc in around 22 h 40 min.

Airlines
American Airlines
Website
aa.com
Flights from Portland to Charlotte
Ave. Duration
2 h 31 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Charlotte via Reagan Washington
Ave. Duration
4 h 34 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Charlotte via Philadelphia
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Columbia via Charlotte
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Columbia via Philadelphia
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Columbia via Reagan Washington
Ave. Duration
5 h 44 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,300
Flights from Portland to Greenville/Spartanburg via Philadelphia
Ave. Duration
5 h 19 min
When
Every day
Estimated price
$240 - $1,100
Flights from Portland to Greenville/Spartanburg via Charlotte
Ave. Duration
5 h 15 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,100
Flights from Portland to Greenville/Spartanburg via Reagan Washington
Ave. Duration
6 h 24 min
When
Every day
Estimated price
$240 - $1,100
Flights from Portland to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
8 h 1 min
When
Every day
Estimated price
$290 - $1,200
Flights from Portland to Charleston via Philadelphia
Ave. Duration
4 h 51 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Charleston via Charlotte
Ave. Duration
5 h 6 min
When
Every day
Estimated price
$290 - $1,300
Flights from Portland to Charleston via Reagan Washington
Ave. Duration
4 h 42 min
When
Every day
Estimated price
$290 - $1,300
Flights from Boston to Charleston via Charlotte
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$150 - $1,100
Flights from Boston to Charleston via Philadelphia
Ave. Duration
4 h 29 min
When
Monday to Saturday
Estimated price
$150 - $1,100
Flights from Boston to Charleston via Reagan Washington
Ave. Duration
4 h 30 min
When
Monday to Friday
Estimated price
$150 - $1,100
Flights from Manchester to Charlotte
Ave. Duration
2 h 26 min
When
Every day
Estimated price
$190 - $950
Flights from Manchester to Charlotte via Reagan Washington
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$190 - $950
United Airlines
Website
united.com
Flights from Portland to Charlotte via Washington Dulles
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$210 - $1,400
Flights from Portland to Charlotte via Newark
Ave. Duration
4 h 35 min
When
Every day
Estimated price
$210 - $1,400
Flights from Portland to Columbia via Chicago O'Hare
Ave. Duration
7 h 44 min
When
Every day
Estimated price
$370 - $1,600
Flights from Portland to Columbia via Washington Dulles
Ave. Duration
8 h 40 min
When
Every day
Estimated price
$300 - $1,400
Flights from Portland to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$250 - $1,200
Flights from Portland to Greenville/Spartanburg via Newark
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$250 - $1,200
Flights from Portland to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
7 h 27 min
When
Every day
Estimated price
$300 - $1,300
Flights from Portland to Charleston via Washington Dulles
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$300 - $1,400
Flights from Boston to Charleston via Washington Dulles
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$190 - $1,200
Flights from Manchester to Charlotte via Newark
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$180 - $1,400
Delta
Website
delta.com
Flights from Portland to Columbia via Atlanta
Ave. Duration
5 h 6 min
When
Monday, Thursday, Friday and Saturday
Estimated price
$300 - $1,400
Flights from Portland to Columbia via New York La Guardia
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$270 - $1,300
Flights from Portland to Greenville/Spartanburg via New York La Guardia
Ave. Duration
5 h 22 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Portland to Greenville/Spartanburg via Atlanta
Ave. Duration
5 h 23 min
When
Every day
Estimated price
$250 - $1,200
Flights from Portland to Greenville/Spartanburg via Detroit
Ave. Duration
5 h 42 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from Portland to Charleston via New York La Guardia
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$270 - $1,300
Flights from Portland to Charleston via Detroit
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$310 - $1,400
Flights from Portland to Charleston via Atlanta
Ave. Duration
5 h 28 min
When
Every day
Estimated price
$300 - $1,400
Flights from Boston to Charleston
Ave. Duration
2 h 39 min
When
Every day
Estimated price
$180 - $1,200
Flights from Manchester to Charlotte via New York La Guardia
Ave. Duration
4 h 57 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$120 - $950
Southwest Airlines
Website
southwest.com
Flights from Portland to Charlotte via Baltimore
Ave. Duration
4 h 10 min
When
Monday to Saturday
Estimated price
$260 - $1,200
Flights from Portland to Charleston via Baltimore
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$320 - $1,300
Flights from Boston to Charleston via Baltimore
Ave. Duration
4 h 25 min
When
Saturday and Sunday
Estimated price
$290 - $1,200
Flights from Manchester to Charlotte via Baltimore
Ave. Duration
4 h 27 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,400
JetBlue Airways
Website
jetblue.com
Flights from Portland to Charleston via New York JFK
Ave. Duration
4 h 42 min
When
Every day
Estimated price
$270 - $1,200
Flights from Boston to Charleston
Ave. Duration
2 h 25 min
When
Every day
Estimated price
$190 - $1,000
Flights from Boston to Charleston via Reagan Washington
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$190 - $1,000
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Portland Transportation Center Amtrak to Haverhill Amtrak
Ave. Duration
1 h 41 min
Frequency
Every 4 hours
Estimated price
$28 - $60
Website
amtrak.com
Coach Seat
$28 - $45
Flexi Coach Seat
$45 - $70
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from New York Penn Station to Florence Amtrak
Ave. Duration
11 h 50 min
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$370 - $550
Amtrak Acela Express
Rome2rio's guide to Amtrak Acela Express
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Boston South Station Amtrak to New York Penn Station
Ave. Duration
3 h 46 min
Frequency
Every 3 hours
Estimated price
$75 - $160
Website
amtrak.com
Coach
$75 - $160
Business Class
$110 - $200
First Class
$291
Bus operators
Concord Coach Lines
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Portland, Me to Boston, Ma
Ave. Duration
2 h 10 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from New York, Ny to Fayetteville, Nc
Ave. Duration
13 h 45 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Fayetteville, Nc to Florence, Sc
Ave. Duration
1 h 35 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Peter Pan Bus Lines
Phone
1-800-343-9999
Website
peterpanbus.com
Bus from Boston, MA - South Station to New York City, NY - Port Authority Bus Terminal
Ave. Duration
3 h 45 min
Frequency
Hourly
Estimated price
$21 - $40
Schedules at
peterpanbus.com
Book at
webstore.peterpanbus.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Boston, MA to New York, NY
Ave. Duration
4 h 15 min
Frequency
Hourly
Estimated price
$16 - $35
Schedules at
us.megabus.com
Bus from New York, NY to Fayetteville, NC
Ave. Duration
14 h 45 min
Frequency
3 times a day
Estimated price
$35 - $70
Schedules at
us.megabus.com

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