There are 7 ways to get from Port St. Lucie to Key West by bus, car, plane or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Fort Lauderdale Airport Station  •  8 h 59 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station 1100 / ...
  2. Take the bus from Miami, Fl to Key West, Fl 3715 / ...

$53 - $118

Cheapest option

Bus  •  9 h

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take the bus from Miami, Fl to Key West, Fl 3715 / ...

$50 - $113

5 alternative options

Drive  •  5 h 20 min

  1. Drive from Port St. Lucie to Key West 274.3 miles

$26 - $40

Bus to Miami, fly  •  5 h 10 min

  1. Take the bus from Fort Pierce to Miami Airport
  2. Fly from Miami (MIA) to Key West (EYW) MIA - EYW

$129 - $453

Fly from Orlando  •  5 h 58 min

  1. Fly from Orlando (MCO) to Key West (EYW) MCO - EYW

$196 - $518

Bus, bus to Fort Lauderdale, fly  •  5 h 35 min

  1. Take the bus from Fort Pierce to West Palm Beach
  2. Take the bus from West Palm Beach to Fort Lauderdale
  3. Fly from Fort Lauderdale (FLL) to Key West (EYW) FLL - EYW

$139 - $437

Bus, shuttle  •  7 h 32 min

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take a shuttle bus from Miami, FL - International Airport to Key West, FL To the Keys

$119 - $173

Questions & Answers

The cheapest way to get from Port St. Lucie to Key West is to drive which costs $26 - $40 and takes 5 h 20 min.

More details

The quickest way to get from Port St. Lucie to Key West is to bus and fly which costs $120 - $460 and takes 5 h 10 min.

More details

The distance between Port St. Lucie and Key West is 210 miles. The road distance is 274.3 miles.

Get driving directions

The best way to get from Port St. Lucie to Key West without a car is to bus which takes 8 h 59 min and costs $50 - $120.

More details

It takes approximately 8 h 59 min to get from Port St. Lucie to Key West, including transfers.

More details

The best way to get from Port St. Lucie to Key West is to bus which takes 8 h 59 min and costs $50 - $120. Alternatively, you can fly, which costs $190 - $550 and takes 5 h 58 min.

Mode details

The quickest flight from Miami Airport to Key West Airport is the direct flight which takes 51 min.

Search flights

Yes, the driving distance between Port St. Lucie to Key West is 274 miles. It takes approximately 5 h 20 min to drive from Port St. Lucie to Key West.

Get driving directions

Map of how to get from Port St. Lucie to Key West.
Launch map view
  • Distance: 210.3 miles
  • Duration: 8 h 59 min

What companies run services between Port St. Lucie, FL, USA and Key West, FL, USA?

You can take a bus from Port St. Lucie to Key West via Fort Lauderdale, FL - Tri-Rail Station, Fort Lauderdale Airport Station, Miami Airport Station, Miami, Fl, Key West, Fl, and Airport/Beaches in around 8 h 59 min. Alternatively, Silver Airways and American Airlines fly from Port St. Lucie to Key West 4 times a day.

Airlines
American Airlines
Website
aa.com
Flights from Miami to Key West
Ave. Duration
55 min
When
Every day
Estimated price
$170 - $650
Flights from Orlando to Key West via Miami
Ave. Duration
3 h 8 min
When
Every day
Estimated price
$180 - $650
Silver Airways
Website
silverairways.com
Flights from Orlando to Key West
Ave. Duration
1 h 31 min
When
Every day
Estimated price
$160 - $800
Flights from Fort Lauderdale to Key West
Ave. Duration
1 h 8 min
When
Every day
Estimated price
$95 - $650
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
Ave. Duration
1 h 35 min
Frequency
Every 4 hours
Estimated price
$27 - $60
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami Airport
Ave. Duration
2 h 15 min
Frequency
Twice daily
Estimated price
$27 - $60
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to West Palm Beach - Travel Plaza
Ave. Duration
45 min
Frequency
Every 4 hours
Estimated price
$27 - $60
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Miami, Fl to Key West, Fl
Ave. Duration
4 h 30 min
Frequency
Hourly
Estimated price
$21 - $50
Website
greyhound.com
Economy
$21 - $35
Flexible
$35 - $50
Red Coach
Phone
+1 877 733 0724
Email
webtickets@redcoachusa.com
Website
redcoachusa.com
Bus from Fort Pierce to Miami Airport
Ave. Duration
2 h 10 min
Frequency
Hourly
Estimated price
$35 - $50
Book at
redcoachusa.com
First Class
$45 - $65
Business
$35 - $50
Bus from Fort Pierce to West Palm Beach
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$26 - $40
Book at
redcoachusa.com
First Class
$35 - $55
Business
$26 - $40
Bus from West Palm Beach to Fort Lauderdale
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$25 - $35
Book at
redcoachusa.com
First Class
$35 - $55
Business
$25 - $35
Keys Shuttle
Phone
+1 (888) 765-9997 | (305) 289-9997
Website
keysshuttle.com
Shuttle from Miami, FL - International Airport to Key West, FL
Ave. Duration
3 h 25 min
Frequency
Every 4 hours
Estimated price
$90 - $110
Schedules at
keysshuttle.com

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