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There are 9 ways to get from Port St. Lucie to Key West by bus, car, plane or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus The Florida Express Bus  •  8h 36m

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Miami, FL - Airport Regency Hotel 102
  2. Take the bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum 400

$56 - $123

Cheapest option

Bus Greyhound USA  •  9h 1m

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take the bus from Miami, Fl to Key West, Fl 3715 / ...

$50 - $113

7 alternative options

Bus via Fort Lauderdale Airport Station  •  9h 44m

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station 1100 / ...
  2. Take the bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum 400

$62 - $131

Drive  •  5h 20m

  1. Drive from Port St. Lucie to Key West 274.3 miles

$26 - $40

Bus to West Palm Beach/Palm Beach, fly  •  4h 28m

  1. Take the bus from Port St Lucie, FL - Travel Plaza to West Palm Beach - Travel Plaza
  2. Fly from West Palm Beach/Palm Beach (PBI) to Key West (EYW) PBI - EYW

$170 - $417

Bus to Miami, fly  •  5h 13m

  1. Take the bus from Fort Pierce to Miami Airport
  2. Fly from Miami (MIA) to Key West (EYW) MIA - EYW

$129 - $453

Bus to Fort Lauderdale, fly  •  5h 25m

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
  2. Fly from Fort Lauderdale (FLL) to Key West (EYW) FLL - EYW

$114 - $403

Shuttle to Orlando, fly  •  5h 57m

  1. Take a shuttle bus from Port St. Lucie, FL - Sunoco to Orlando Airport
  2. Fly from Orlando (MCO) to Key West (EYW) MCO - EYW

$196 - $518

Bus, shuttle  •  8h 8m

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take a shuttle bus from Miami, FL - International Airport to Key West, FL To the Keys

$119 - $173

Questions & Answers

The cheapest way to get from Port St. Lucie to Key West is to drive which costs $26 - $40 and takes 5h 20m.

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The quickest way to get from Port St. Lucie to Key West is to bus and fly which costs $170 - $420 and takes 4h 28m.

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No, there is no direct bus from Port St. Lucie to Key West. However, there are services departing from Port St Lucie, FL - Travel Plaza and arriving at Flagler & Grinnell via Miami, FL - Airport Regency Hotel and Emma & Petronia. The journey, including transfers, takes approximately 8h 36m.

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The distance between Port St. Lucie and Key West is 210 miles. The road distance is 274.3 miles.

Get driving directions

The best way to get from Port St. Lucie to Key West without a car is to bus which takes 8h 36m and costs $55 - $130.

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It takes approximately 8h 36m to get from Port St. Lucie to Key West, including transfers.

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Port St. Lucie to Key West bus services, operated by The Florida Express Bus, depart from Port St Lucie, FL - Travel Plaza station.

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The quickest flight from West Palm Beach/Palm Beach Airport to Key West Airport is the direct flight which takes 1h 20m.

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Port St. Lucie to Key West bus services, operated by The Florida Express Bus, arrive at Key West, FL - Mel Fisher Museum station.

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Yes, the driving distance between Port St. Lucie to Key West is 274 miles. It takes approximately 5h 20m to drive from Port St. Lucie to Key West.

Get driving directions

Map of how to get from Port St. Lucie to Key West.
Launch map view
  • Distance: 210.3 miles
  • Duration: 8h 36m

What companies run services between Port St. Lucie, FL, USA and Key West, FL, USA?

You can take a bus from Port St. Lucie to Key West via Miami, FL - Airport Regency Hotel, Key West, FL - Mel Fisher Museum, and Emma & Petronia in around 8h 36m.

Airlines
American Airlines
Website
aa.com
Flights from Miami to Key West
Ave. Duration
56m
When
Every day
Estimated price
$170 - $650
Flights from Orlando to Key West via Miami
Ave. Duration
3h 10m
When
Every day
Estimated price
$180 - $650
Silver Airways
Website
silverairways.com
Flights from Fort Lauderdale to Key West
Ave. Duration
1h 10m
When
Every day
Estimated price
$95 - $650
Flights from Orlando to Key West
Ave. Duration
1h 30m
When
Every day
Estimated price
$160 - $800
Flights from Orlando to Key West via Fort Lauderdale
Ave. Duration
3h 40m
When
Every day
Estimated price
$160 - $800
Southern Airways Express
Website
iflysouthern.com
Flights from West Palm Beach/Palm Beach to Key West
Ave. Duration
1h 20m
When
Every day
Estimated price
$120 - $330
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami, FL - Airport Regency Hotel
Ave. Duration
2h 15m
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum
Ave. Duration
4h
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Port St Lucie, FL - Travel Plaza to Miami Airport
Ave. Duration
2h 15m
Frequency
Twice daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
Ave. Duration
1h 35m
Frequency
Every 4 hours
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Port St Lucie, FL - Travel Plaza to West Palm Beach - Travel Plaza
Ave. Duration
45m
Frequency
Every 4 hours
Estimated price
$27 - $60
More information at
American Bus Tickets
Red Coach
Phone
+1 877 733 0724
Email
webtickets@redcoachusa.com
Website
redcoachusa.com
Bus from Fort Pierce to Miami Airport
Ave. Duration
2h 10m
Frequency
5 times a day
Estimated price
$35 - $50
Book at
redcoachusa.com
First Class
$45 - $65
Business
$35 - $50
Bus from Fort Pierce to West Palm Beach
Ave. Duration
45m
Frequency
5 times a day
Estimated price
$26 - $40
Book at
redcoachusa.com
First Class
$35 - $55
Business
$26 - $40
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Miami, Fl to Key West, Fl
Ave. Duration
4h 30m
Frequency
Twice daily
Estimated price
$21 - $50
Website
greyhound.com
Economy
$21 - $35
Flexible
$35 - $50
Smart Shuttle Line, Inc.
Phone
772-343-0217
Email
smartshuttleline@hotmail.com
Website
smartshuttleline.com
Shuttle from Port St. Lucie, FL - Sunoco to Orlando Airport
Ave. Duration
2h 18m
Frequency
5 times a day
Estimated price
$84
Schedules at
smartshuttleline.com
Keys Shuttle
Phone
+1 (888) 765-9997 | (305) 289-9997
Website
keysshuttle.com
Shuttle from Miami, FL - International Airport to Key West, FL
Ave. Duration
3h 45m
Frequency
Every 4 hours
Estimated price
$90 - $110
Schedules at
keysshuttle.com

Want to know more about travelling around United States

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More Questions & Answers

Southern Airways Express offers flights from West Palm Beach/Palm Beach Airport to Key West Airport.

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There are 338+ hotels available in Key West. Prices start at $165 USD per night.

More details

The best way to get from Port St. Lucie to Orlando Airport is to shuttle which takes 2h 18m and costs $84.

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