There are 7 ways to get from Port St. Lucie to Key West by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus Go Buses  •  7 h 15 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Miami 1100 / ...
  2. Take the bus from Miami, FL to Key West, FL

$50

Cheapest option

Bus Greyhound USA  •  8 h 59 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station 1100 / ...
  2. Take the bus from Miami, Fl to Key West, Fl 3715 / ...

$46 - $79

5 alternative options

Bus  •  8 h 18 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Miami, FL - Airport Regency Hotel 102
  2. Take the bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum 400

$57 - $74

Drive  •  5 h 20 min

  1. Drive from Port St. Lucie to Key West 274.3 miles

$26 - $40

Bus to Fort Lauderdale, fly  •  5 h 3 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
  2. Fly from Fort Lauderdale (FLL) to Key West (EYW) FLL - EYW

$107 - $364

Bus to Miami, fly  •  5 h 14 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Miami Airport
  2. Fly from Miami (MIA) to Key West (EYW) MIA - EYW

$127 - $419

Fly from Orlando  •  5 h 57 min

  1. Fly from Orlando (MCO) to Key West (EYW) MCO - EYW

$196 - $518

What companies run services between Port St. Lucie, FL, USA and Key West, FL, USA?

You can take a bus from Port St. Lucie to Key West via Miami and Miami, FL in around 7 h 15 min. Alternatively, Silver Airways and American Airlines fly from Port St. Lucie to Key West every 4 hours.

Airlines
Silver Airways
Website
silverairways.com
Flights from Fort Lauderdale to Key West
Ave. Duration
1 h 8 min
When
Every day
Estimated price
$95 - $650
Flights from Orlando to Key West
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$160 - $800
Flights from Orlando to Key West via Fort Lauderdale
Ave. Duration
3 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $800
American Airlines
Website
aa.com
Flights from Miami to Key West
Ave. Duration
53 min
When
Every day
Estimated price
$170 - $650
Flights from Orlando to Key West via Miami
Ave. Duration
3 h 22 min
When
Every day
Estimated price
$180 - $650
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami
Ave. Duration
2 h 25 min
Frequency
5 times a day
Estimated price
$25
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami, FL - Airport Regency Hotel
Ave. Duration
2 h 15 min
Frequency
Once daily
Estimated price
$26
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum
Ave. Duration
4 h
Frequency
Once daily
Estimated price
$30 - $45
Schedules at
thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
Ave. Duration
1 h 35 min
Frequency
Every 4 hours
Estimated price
$20
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami Airport
Ave. Duration
2 h 15 min
Frequency
Twice daily
Estimated price
$25
Schedules at
webstore.thefloridaexpressbus.com
Book at
busticketreservations.com
Go Buses
Phone
1 855 888-7160
Email
gobuses@facebook.com
Website
gobuses.com
Bus from Miami, FL to Key West, FL
Ave. Duration
3 h 45 min
Frequency
Twice daily
Estimated price
$25
Schedules at
gobuses.com
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Miami, Fl to Key West, Fl
Ave. Duration
4 h 30 min
Frequency
Hourly
Estimated price
$21 - $50
Website
greyhound.com
Economy
$21 - $35
Flexible
$35 - $50

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Questions & Answers

The distance between Port St. Lucie and Key West is 336 km. The road distance is 439 km.

The cheapest way to get from Port St. Lucie to Key West is to drive which costs $26 - $40 and takes 5 h 20 min.

The quickest way to get from Port St. Lucie to Key West is to bus and fly which takes 5 h 3 min and costs $100 - $370.

No, there is no direct bus from Port St. Lucie to Key West. However, there are services departing from Port St Lucie, FL - Travel Plaza and arriving at Key West, FL via Miami, FL. The journey, including transfers, takes approximately 7 h 15 min.

It takes approximately 7 h 15 min to get from Port St. Lucie to Key West, including transfers.