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There are 7 ways to get from Port St. Lucie to Florida Keys by bus, car, plane or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  8 h 39 min

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take the bus from Miami, Fl to Big Pine Key 3715 / ...

$48 - $108

6 alternative options

Bus via Fort Lauderdale Airport Station  •  9 h 7 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station 1100 / ...
  2. Take the bus from Miami, Fl to Big Pine Key 3715 / ...

$51 - $113

Drive  •  4 h 59 min

  1. Drive from Port St. Lucie to Florida Keys 258.7 miles

$25 - $40

Bus to Miami, fly  •  5 h 49 min

  1. Take the bus from Fort Pierce to Miami Airport
  2. Fly from Miami (MIA) to Key West (EYW) MIA - EYW

$129 - $453

Bus to Fort Lauderdale, fly  •  6 h 3 min

  1. Take the bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
  2. Fly from Fort Lauderdale (FLL) to Key West (EYW) FLL - EYW

$114 - $403

Shuttle to Orlando, fly  •  6 h 35 min

  1. Take a shuttle bus from Port St. Lucie, FL - Sunoco to Orlando Airport
  2. Fly from Orlando (MCO) to Key West (EYW) MCO - EYW

$196 - $518

Bus, shuttle  •  7 h 40 min

  1. Take the bus from Fort Pierce to Miami Airport RedCoach / ...
  2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL To the Keys

$109 - $158

Questions & Answers

The cheapest way to get from Port St. Lucie to Florida Keys is to drive which costs $25 - $40 and takes 4 h 59 min.

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The quickest way to get from Port St. Lucie to Florida Keys is to drive which costs $25 - $40 and takes 4 h 59 min.

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The distance between Port St. Lucie and Florida Keys is 199 miles. The road distance is 258.7 miles.

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The best way to get from Port St. Lucie to Florida Keys without a car is to bus which takes 8 h 39 min and costs $45 - $110.

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It takes approximately 8 h 39 min to get from Port St. Lucie to Florida Keys, including transfers.

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The quickest flight from Miami Airport to Key West Airport is the direct flight which takes 52 min.

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Yes, the driving distance between Port St. Lucie to Florida Keys is 259 miles. It takes approximately 4 h 59 min to drive from Port St. Lucie to Florida Keys.

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American Airlines offers flights from Miami Airport to Key West Airport.

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There are 22+ hotels available in Florida Keys. Prices start at $100 USD per night.

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The best way to get from Port St. Lucie to Orlando Airport is to shuttle which takes 2 h 18 min and costs $84.

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Map of how to get from Port St. Lucie to Florida Keys.
Launch map view
  • Distance: 199.1 miles
  • Duration: 8 h 39 min

What companies run services between Port St. Lucie, FL, USA and Florida Keys, FL, USA?

You can take a bus from Port St. Lucie to Florida Keys via Miami Airport, Mia@Lower Level Ramp, Airport Station, Miami, Fl, Big Pine Key, Lower Keys Shuttle, and Sugarloaf Key, FL in around 8 h 39 min.

Airlines
American Airlines
Website
aa.com
Flights from Miami to Key West
Ave. Duration
56 min
When
Every day
Estimated price
$170 - $650
Flights from Orlando to Key West via Miami
Ave. Duration
3 h 17 min
When
Every day
Estimated price
$180 - $650
Silver Airways
Website
silverairways.com
Flights from Fort Lauderdale to Key West
Ave. Duration
1 h 10 min
When
Every day
Estimated price
$95 - $650
Flights from Orlando to Key West
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$160 - $800
Bus operators
Red Coach
Phone
+1 877 733 0724
Email
webtickets@redcoachusa.com
Website
redcoachusa.com
Bus from Fort Pierce to Miami Airport
Ave. Duration
2 h 10 min
Frequency
5 times a day
Estimated price
$35 - $50
Book at
redcoachusa.com
First Class
$45 - $65
Business
$35 - $50
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Port St Lucie, FL - Travel Plaza to Miami Airport
Ave. Duration
2 h 15 min
Frequency
Twice daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Port St Lucie, FL - Travel Plaza to Fort Lauderdale, FL - Tri-Rail Station
Ave. Duration
1 h 35 min
Frequency
Every 4 hours
Estimated price
$27 - $60
More information at
American Bus Tickets
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Miami, Fl to Big Pine Key
Ave. Duration
3 h 35 min
Frequency
Twice daily
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$30 - $45
Smart Shuttle Line, Inc.
Phone
772-343-0217
Email
smartshuttleline@hotmail.com
Website
smartshuttleline.com
Shuttle from Port St. Lucie, FL - Sunoco to Orlando Airport
Ave. Duration
2 h 18 min
Frequency
5 times a day
Estimated price
$84
Schedules at
smartshuttleline.com
Keys Shuttle
Phone
+1 (888) 765-9997 | (305) 289-9997
Website
keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
Ave. Duration
3 h
Frequency
5 times a day
Estimated price
$80 - $95
Schedules at
keysshuttle.com

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