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How to get fromPort Isabel to Key Westby plane, bus, ferry or car

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There are 6 ways to get from Port Isabel to Key West by plane, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Brownsville-South Padre Island International Airport

    best
    1. Fly from Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW)plane plane BRO - EYW
    7h 3m
    $153–715

  2. Bus to Mcallen Miller International Airport, fly

    cheapest
    1. Take the bus from Brownsville to McAllen Central Stationbus bus
    2. Fly from Mcallen Miller International Airport (MFE) to Key West International Airport (EYW)plane plane MFE - EYW
    9h 17m
    $140–677

  3. Bus, ferry

    1. Take the bus from Brownsville Bus Station to Houston - Harrisburg Blvdbus bus
    2. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    35h 19m
    $397–482

  4. Drive 1,687.7 mi

    1. Drive from Port Isabel to Key Westcar car 1,687.7 mi
    30h 17m
    $308–445

  5. Bus, ferry via Houston

    1. Take the bus from La Plaza at Brownsville to Houston Bus Stationbus bus
    2. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    36h 39m
    $367–482

  6. Bus, ferry via Arcadia

    1. Take the bus from Matamoros to Houstonbus bus
    2. Take the bus from Houston to Billar El Mexicano - Arcadiabus bus
    3. Take the bus from Arcadia to Fort Myersbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    43h 13m
    $435–647

Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW) flights

Calendar9Weekly Planes
Duration6h 46mAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

What companies run services between Port Isabel, TX, USA and Key West, FL, USA?

United Airlines and American Airlines fly from Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW) once daily.

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