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How to get fromPort Isabel to Key Westby plane, bus, ferry or car

Find Transport to Key West

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There are 6 ways to get from Port Isabel to Key West by plane, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Brownsville-South Padre Island International Airport

    best
    1. Fly from Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW)planeBRO - EYW
    6h 53m
    $133–615

  2. Bus, ferry

    1. Take the bus from Brownsville Bus Station to Houston - Harrisburg Blvdbus
    2. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry
    35h 18m
    $397–482

  3. Drive 1,687.6 mi

    1. Drive from Port Isabel to Key Westcar1,687.6 mi
    30h 4m
    $308–445

  4. Bus to Mcallen Miller International Airport, fly

    1. Take the bus from Brownsville to McAllen Central Stationbus
    2. Fly from Mcallen Miller International Airport (MFE) to Key West International Airport (EYW)planeMFE - EYW
    9h 39m
    $140–677

  5. Bus, ferry via Houston

    1. Take the bus from La Plaza at Brownsville to Houston Bus Stationbus
    2. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry
    36h 38m
    $367–482

  6. Bus, ferry via Arcadia

    1. Take the bus from Matamoros to Houstonbus
    2. Take the bus from Houston to Billar El Mexicano - Arcadiabus
    3. Take the bus from Arcadia to Fort Myersbus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry
    43h 13m
    $435–647

Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW) flights

Calendar21Weekly Planes
Duration7h 38mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

What companies run services between Port Isabel, TX, USA and Key West, FL, USA?

United Airlines and American Airlines fly from Brownsville-South Padre Island International Airport (BRO) to Key West International Airport (EYW) 3 times a day.

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