Rome2Rio

How to get fromPoplar Bluff to Buffaloby car, plane, bus, train (Amtrak) or train

Find Transport to Buffalo

See all options

There are 7 ways to get from Poplar Bluff to Buffalo by car, plane, bus, train (Amtrak), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Barkley Regional Airport, fly

    best
    1. Drive from Poplar Bluff to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Buffalo Niagara International Airport (BUF)plane plane PAH - BUF
    10h 9m
    $381–2,029

  2. Drive, bus

    cheapest
    1. Drive from Poplar Bluff to Flying J - Matthewscar car
    2. Take the bus from Flying J - Matthews to Tornado Bus Co - Chicagobus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    22h 13m
    $148–347

  3. Train (Amtrak)

    1. Take the train from Poplar Bluff Station to Chicago Union Stationtrain train Texas Eagle
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    23h 44m
    $252–623

  4. Drive 850.6 mi

    1. Drive from Poplar Bluff to Buffalocar car 850.6 mi
    14h 31m
    $156–225

  5. Train to Lambert–St. Louis International Airport, fly

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    10h 53m
    $307–1,596

  6. Drive to Cape Girardeau Municipal Airport, fly

    1. Drive from Poplar Bluff to Cape Girardeau Municipal Airport (CGI)car car
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Buffalo Niagara International Airport (BUF)plane plane CGI - BUF
    8h 29m
    $285–1,520

  7. Train, bus

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh to Buffalobus bus
    27h 31m
    $182–461

Poplar Bluff to Buffalo by train (Amtrak)

Calendar10Weekly Trains
Duration23h 44mAverage Duration
Ticket$252Cheapest Price
See schedules

Questions & Answers

What companies run services between Poplar Bluff, MO, USA and Buffalo, NY, USA?

You can take a train from Poplar Bluff Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 23h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Poplar Bluff

Trips to Buffalo

Popular routes