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How to get fromPittsburgh to Murphysboroby plane, car, bus (Greyhound, Amtrak, Flixbus), train (Amtrak), bus, train or bus (Flixbus)

Find Transport to Murphysboro

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There are 9 ways to get from Pittsburgh to Murphysboro by plane, car, bus (Greyhound, Amtrak, Flixbus), train (Amtrak), bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Barkley Regional Airport, drive

    best
    1. Fly from Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH)planePIT - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar
    8h 47m
    $139–664

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to St Louis Bus StationbusGreyhound US0421
    2. Take the bus from St. Louis to CarbondalebusAmtrak Thruway Connecting Service
    16h 5m
    $108–265

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union StationtrainFloridian
    2. Take the train from Chicago Union Station to CarbondaletrainCity of New Orleans / ...
    16h 12m
    $139–369

  4. Drive 607 mi

    1. Drive from Pittsburgh to Murphysborocar607 mi
    10h 39m
    $111–160

  5. Fly Pittsburgh International Airport to Lambert–St. Louis International Airport, bus

    1. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)planePIT - STL
    2. Take the bus from St. Louis to Carbondalebus
    7h 42m
    $169–720

  6. Fly Pittsburgh International Airport to Williamson County Regional Airport

    1. Fly from Pittsburgh International Airport (PIT) to Williamson County Regional Airport (MWA)planePIT - MWA
    6h 55m
    $123–465

  7. Fly Pittsburgh International Airport to Nashville, bus

    1. Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)planePIT - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus
    9h 45m
    $174–456

  8. Train to Cleveland-Hopkins International Airport, fly to Lambert–St. Louis International Airport, bus

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)planeCLE - STL
    3. Take the bus from St. Louis to Carbondalebus
    10h 24m
    $250–646

  9. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Pittsburgh Intermodal Station to ChicagobusFlixBus N2640
    2. Take the bus from Chicago to Carbondale Intermodal StationbusFlixBus N2521
    20h 30m
    $126–220

Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH) flights

Calendar29Weekly Planes
Duration6h 7mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

What companies run services between Pittsburgh, PA, USA and Murphysboro, IL, USA?

You can take a bus from Pittsburgh Intermodal Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 16h 5m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Murphysboro via Chicago Union Station and Carbondale in around 16h 12m.

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