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How to get fromPittsburgh to Murphysboroby plane, car, bus (Greyhound, Amtrak, Flixbus), train (Amtrak), bus, train or bus (Flixbus)

Find Transport to Murphysboro

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There are 9 ways to get from Pittsburgh to Murphysboro by plane, car, bus (Greyhound, Amtrak, Flixbus), train (Amtrak), bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Barkley Regional Airport, drive

    best
    1. Fly from Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH)plane plane PIT - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    8h 43m
    $152–776

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    16h 5m
    $102–215

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to Carbondaletrain train City of New Orleans / ...
    16h 12m
    $118–295

  4. Drive 607 mi

    1. Drive from Pittsburgh to Murphysborocar car 607 mi
    10h 45m
    $111–160

  5. Fly Pittsburgh International Airport to Lambert–St. Louis International Airport, bus

    1. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    8h 11m
    $322–767

  6. Fly Pittsburgh International Airport to Nashville, bus

    1. Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)plane plane PIT - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    9h 40m
    $182–427

  7. Fly Pittsburgh International Airport to Williamson County Regional Airport

    1. Fly from Pittsburgh International Airport (PIT) to Williamson County Regional Airport (MWA)plane plane PIT - MWA
    7h 37m
    $122–482

  8. Train to Cleveland-Hopkins International Airport, fly to Lambert–St. Louis International Airport, bus

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3. Take the bus from St. Louis to Carbondalebus bus
    10h 39m
    $243–541

  9. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    2. Take the bus from Chicago to Carbondale Intermodal Stationbus bus FlixBus N2521
    20h 30m
    $131–185

Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH) flights

Calendar29Weekly Planes
Duration6h 6mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

What companies run services between Pittsburgh, PA, USA and Murphysboro, IL, USA?

You can take a bus from Pittsburgh Intermodal Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 16h 5m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Murphysboro via Chicago Union Station and Carbondale in around 16h 12m.

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