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How to get fromPittsburgh to Depewby train (Amtrak), bus (Greyhound), car, plane, or bus

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There are 5 ways to get from Pittsburgh to Depew by train (Amtrak), bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train Floridian
    2. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    7h 1m
    $106–217

  2. Bus via Erie

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Eriebus bus Greyhound US0440s
    2. Take the bus from Erie, PA to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    7h 53m
    $36–67

  3. Drive 218.8 mi

    1. Drive from Pittsburgh to Depewcar car 218.8 mi
    3h 49m
    $40–58

  4. Fly

    1. Fly from Pittsburgh International Airport (PIT) to Buffalo Niagara International Airport (BUF)plane plane PIT - BUF
    6h 5m
    $177–939

  5. Bus

    1. Take the bus from Pittsburgh to Buffalobus bus Fab510
    9h 48m
    $105–193

Pittsburgh to Depew by bus

Calendar7Weekly Buses
Duration7h 53mAverage Duration
Ticket$36Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Depew.ExpandLaunch map view
  • Distance: 326.4 mi
  • Duration: 7h 1m

What companies run services between Pittsburgh, PA, USA and Depew, NY, USA?

You can take a train from Pittsburgh Amtrak Station to Depew via Cleveland Amtrak and Buffalo Depew Station in around 7h 1m. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Broadway & Elwood Avenue via Erie, Erie, PA, and Ellicott Street & MTC Static in around 7h 53m.

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