Rome2Rio

How to get fromPittsburgh to Depewby bus (Greyhound), train (Amtrak), car, plane or bus

Find Transport to Depew

See all options

There are 5 ways to get from Pittsburgh to Depew by bus (Greyhound), train (Amtrak), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Erie

    best
    1. Take the bus from Pittsburgh Intermodal Station to EriebusGreyhound US0440s
    2. Take the bus from Erie, PA to Buffalo, NYbusCinncinati,OH-Buffalo
    7h 54m
    $40–103

  2. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Cleveland AmtraktrainFloridian
    2. Take the train from Cleveland Amtrak to Buffalo Depew StationtrainLake Shore Limited
    8h
    $63–163

  3. Drive 218.8 mi

    1. Drive from Pittsburgh to Depewcar218.8 mi
    3h 47m
    $40–58

  4. Fly

    1. Fly from Pittsburgh International Airport (PIT) to Buffalo Niagara International Airport (BUF)planePIT - BUF
    5h 40m
    $200–1,097

  5. Bus

    1. Take the bus from Pittsburgh to BuffalobusFab510
    9h 49m
    $46–176

Pittsburgh to Depew by bus

Calendar7Weekly Buses
Duration7h 54mAverage Duration
Ticket$40Cheapest Price
See schedules

Questions & Answers

What companies run services between Pittsburgh, PA, USA and Depew, NY, USA?

You can take a bus from Pittsburgh Intermodal Station to Broadway & Elwood Avenue via Erie, Erie, PA, and Ellicott Street & MTC Static in around 7h 54m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Broadway & Canton Street via Cleveland Amtrak, Buffalo Depew Station, and Broadway & Dick Road in around 8h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Pittsburgh

Trips to Depew

Popular routes