Greyhound USA operates a bus from Pittsburgh to Columbus 4 times a day. Tickets cost $24 - $60 and the journey takes 3 h 57 min. Alternatively, Southwest Airlines, Delta and 2 other airlines fly from Pittsburgh to Columbus hourly.
From Pittsburgh, PA bus to Columbus, OH. 3 h 57 min $42. From Pittsburgh drive to Columbus. 3 h 7 min $22. From Seventh Ave At Smithfield St bus to Pittsburgh airport, fly to Columbus airport, then bus to Columbus. 5 h 26 min $416.