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How to get fromPittsburgh to Chicago, ILby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train or bus (Flixbus)

Find Transport to Chicago, IL

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There are 9 ways to get from Pittsburgh to Chicago, IL by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    5h

  2. Bus to Morgantown Municipal Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Pittsburgh Greyhound to Westover Terminalbus bus
    2. Fly from Morgantown Municipal Airport (MGW) to Chicago O'Hare International Airport (ORD)plane plane MGW - ORD
    7h 29m
    $51–306

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    9h 55m
    $60–200

  4. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    10h 20m
    $55–160

  5. Drive 460.5 mi

    1. Drive from Pittsburgh to Chicago, ILcar car 460.5 mi
    7h 30m
    $84–122

  6. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    4h 44m

  7. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    5h 47m
    $80–314

  8. Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    7h 13m
    $101–503

  9. Bus via Chicago (Flixbus)

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    11h 32m
    $66–112

Pittsburgh to Chicago, IL by train and foot (Amtrak)

Calendar7Weekly Services
Duration9h 55mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

What companies run services between Pittsburgh, PA, USA and Chicago, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $60–200 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $55–160 and the journey takes 10h 20m. Flixbus USA also services this route once daily.

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