There are 8 ways to get from Pittsburgh to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport
best- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)PIT - MDW
4h 16mBus
cheapest- Take the bus from Pittsburgh Intermodal Station to Chicago Bus StationGreyhound US0164
10h 20m$55–160Train (Amtrak)
- Take the train from Pittsburgh Amtrak Station to Chicago Union StationFloridian
9h 46m$70–200Drive 460 mi
- Drive from Pittsburgh to Chicago460 mi
7h 30m$84–122Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport
- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)PIT - ORD
4h 43mTrain to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport
- Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Station
- Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)JST - ORD
5h 40m$80–314Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport
- Take the train from Pittsburgh Amtrak Station to Cleveland Amtrak
- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)CLE - MDW
6h 53m$104–494Bus via Chicago (Flixbus)
- Take the bus from Pittsburgh Intermodal Station to ChicagoFlixBus N2640
11h 21m$64–107
Pittsburgh to Chicago by train (Amtrak)
Questions & Answers
The cheapest way to get from Pittsburgh to Chicago is to bus which costs $55 - $160 and takes 10h 20m.
The fastest way to get from Pittsburgh to Chicago is to train and fly which takes 5h 40m and costs $80 - $320.
Yes, there is a direct bus departing from Pittsburgh Intermodal Station station and arriving at Chicago Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 10h 20m.
Yes, there is a direct train departing from Pittsburgh Amtrak Station station and arriving at Chicago Union Station station. Services depart once daily, and operate every day. The journey takes approximately 9h 46m.
The distance between Pittsburgh and Chicago is 438 miles. The road distance is 462.7 miles.
The best way to get from Pittsburgh to Chicago without a car is to train which takes 9h 46m and costs $70 - $200.
It takes approximately 4h 16m to get from Pittsburgh to Chicago, including transfers.
Pittsburgh to Chicago bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Chicago train services, operated by Amtrak, depart from Pittsburgh Amtrak Station.
The best way to get from Pittsburgh to Chicago is to train which takes 9h 46m and costs $70 - $200. Alternatively, you can bus, which costs $55 - $160 and takes 10h 20m.
What companies run services between Pittsburgh, PA, USA and Chicago, IL, USA?
Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $70–200 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $55–160 and the journey takes 10h 20m. Flixbus USA also services this route once daily.
- Website
- southwest.com
Flights from Pittsburgh International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $65–390
Flights from Pittsburgh International Airport to Chicago Midway International Airport via St. Louis
- Ave. Duration
- 4h
- When
- Saturday
- Estimated price
- $90–470
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $65–410
- Website
- united.com
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- $45–290
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $65–350
Flights from Johnstown-Cambria County Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 11m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $45–270
- Website
- aa.com
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 58m
- When
- Every day
- Estimated price
- $45–290
- Website
- delta.com
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 3h 37m
- When
- Every day
- Estimated price
- $50–300
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- $65–410
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $70–200
- Website
- https://www.amtrak.com/home.html
Train from Pittsburgh Amtrak Station to Johnstown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $18–22
- Website
- https://www.amtrak.com/home.html
Train from Pittsburgh Amtrak Station to Cleveland Amtrak
- Ave. Duration
- 2h 54m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 412-442-2000
- Website
- rideprt.org
Bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Ave. Duration
- 49 min
- Frequency
- Hourly
- Website
- https://www.rideprt.org
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Pittsburgh Intermodal Station to Chicago Bus Station
- Ave. Duration
- 10h 20m
- Frequency
- Twice daily
- Estimated price
- $55–160
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Pittsburgh Intermodal Station to Chicago Bus Station
- Ave. Duration
- 11h 25m
- Frequency
- Once daily
- Estimated price
- $60–130
- Schedules at
- flixbus.com
Bus from Pittsburgh Intermodal Station to Chicago
- Ave. Duration
- 10h 55m
- Frequency
- Once daily
- Estimated price
- $60–110
- Schedules at
- flixbus.com
- Adult
- $60–110
Want to know more about travelling around United States
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More Questions & Answers
Pittsburgh to Chicago bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Chicago is 1h behind Pittsburgh. It is currently 5:59 PM in Pittsburgh and 4:59 PM in Chicago.
Pittsburgh to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Pittsburgh to Chicago is 463 miles. It takes approximately 7h 30m to drive from Pittsburgh to Chicago.
Book your Pittsburgh to Chicago train tickets online with Omio.
Book your Pittsburgh to Chicago bus tickets online with Omio and FlixBus.
There are 1245+ hotels available in Chicago.