There are 7 ways to get from Pittsburgh to Buffalo–Depew Station by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  6 h 50 min

  1. Capitol Limited
  2. Lake Shore Limited

$76 - $176

Cheapest option

Bus Greyhound USA  •  7 h 3 min

  1. 4646 / ...
  2. 4178 / ...

$37 - $84

5 alternative options

Bus Fullington Trailways  •  9 h 48 min

  1. 710 Pittsburgh / ...
  2. 510 DuBois

$69 - $124

Drive  •  3 h 47 min

  1. 220.2 miles

$21 - $35

Fly to Buffalo  •  6 h 52 min

  1. PIT - BUF

$94 - $554

Fly to Bradford, bus  •  7 h 54 min

  1. PIT - BFD

$170 - $380

Fly to Toronto, train  •  10 h 27 min

  1. PIT - YYZ

$136 - $472

What companies run services between Pittsburgh, PA, USA and Buffalo–Depew Station, NY, USA?

You can take a train from Pittsburgh to Buffalo–Depew Station via Cleveland Amtrak in around 6 h 50 min. Alternatively, you can take a bus from Pittsburgh to Buffalo–Depew Station via Erie, Pa, Buffalo, Ny, Ellicott St & North Division St, and Walden Ave & Thruway Transit Center in around 7 h 3 min.

Airlines
United Airlines
Website
united.com
Flights from Pittsburgh to Buffalo via Washington Dulles
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$170 - $850
Flights from Pittsburgh to Buffalo via Chicago O'Hare
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$200 - $950
Flights from Pittsburgh to Buffalo via Newark
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$180 - $900
Flights from Pittsburgh to Toronto
Ave. Duration
1 h 8 min
When
Every day
Estimated price
$150 - $800
American Airlines
Website
aa.com
Flights from Pittsburgh to Buffalo via Reagan Washington
Ave. Duration
3 h 41 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $850
Flights from Pittsburgh to Buffalo via Philadelphia
Ave. Duration
4 h 1 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Pittsburgh to Buffalo via Charlotte
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$190 - $900
Flights from Pittsburgh to Buffalo via Chicago O'Hare
Ave. Duration
4 h 34 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $900
Southern Airways Express
Website
iflysouthern.com
Flights from Pittsburgh to Bradford
Ave. Duration
55 min
When
Every day
Estimated price
$65 - $190
Delta
Website
delta.com
Flights from Pittsburgh to Buffalo via Detroit
Ave. Duration
3 h 41 min
When
Every day
Estimated price
$150 - $800
Flights from Pittsburgh to Buffalo via New York JFK
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$160 - $850
Flights from Pittsburgh to Buffalo via New York La Guardia
Ave. Duration
4 h 29 min
When
Monday to Friday
Estimated price
$160 - $850
Air Canada
Website
aircanada.com
Flights from Pittsburgh to Buffalo via Chicago O'Hare
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$200 - $950
Flights from Pittsburgh to Toronto
Ave. Duration
1 h 8 min
When
Every day
Estimated price
$150 - $800
Southwest Airlines
Website
southwest.com
Flights from Pittsburgh to Buffalo via Chicago Midway
Ave. Duration
3 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $850
OneJet
Website
onejet.com
Flights from Pittsburgh to Buffalo via Albany
Ave. Duration
4 h
When
Monday to Friday
Estimated price
$90 - $550
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Pittsburgh Amtrak to Cleveland Amtrak
Ave. Duration
2 h 54 min
Frequency
Once daily
Estimated price
$35 - $85
Website
amtrak.com
Coach Seat
$35 - $55
Flexi Coach Seat
$60 - $90
Business Coach Seat
$55 - $85
Room
$180 - $250
Train from Cleveland Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
2 h 56 min
Frequency
Twice daily
Estimated price
$40 - $95
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $100
Business Coach Seat
$65 - $95
Room
$190 - $270
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Toronto to Buffalo
Ave. Duration
5 h 11 min
Frequency
Every 3 hours
Estimated price
$30 - $90
Website
viarail.ca
Escape
$30 - $45
Economy
$40 - $60
Economy Plus
$65 - $90
Business
$60 - $85
Business Plus/Sleeper
$100 - $150
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Pittsburgh, Pa to Erie, Pa
Ave. Duration
3 h 19 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Bus from Erie, Pa to Buffalo, Ny
Ave. Duration
1 h 50 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Fullington Trailways
Phone
+1 800.942.8287
Website
fullingtontours.com
Bus from Pittsburgh, PA to Dubois, PA
Ave. Duration
2 h 30 min
Frequency
Twice daily
Estimated price
$27 - $50
Schedules at
fullingtontours.com
Book at
fab.tdstickets.com
Bus from Dubois, PA to Buffalo, NY
Ave. Duration
4 h 40 min
Frequency
Once daily
Estimated price
$40 - $75
Schedules at
fullingtontours.com
Book at
fab.tdstickets.com
Bus from Bradford, PA to Buffalo, NY
Ave. Duration
2 h 40 min
Frequency
Once daily
Estimated price
$27 - $65
Schedules at
fullingtontours.com
Book at
fab.tdstickets.com

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Questions & Answers

The distance between Pittsburgh and Buffalo–Depew Station is 294 km. The road distance is 352 km.

The cheapest way to get from Pittsburgh to Buffalo–Depew Station is to drive which costs $21 - $35 and takes 3 h 47 min.

The quickest way to get from Pittsburgh to Buffalo–Depew Station is to drive which takes 3 h 47 min and costs $21 - $35.

No, there is no direct train from Pittsburgh to Buffalo–Depew Station. However, there are services departing from Pittsburgh Amtrak and arriving at Buffalo Depew Station Amtrak via Cleveland Amtrak. The journey, including transfers, takes approximately 6 h 50 min.

No, there is no direct bus from Pittsburgh to Buffalo–Depew Station. However, there are services departing from Pittsburgh, Pa and arriving at Amtrak Station & Dick Rd via Erie, Pa, Ellicott St & North Division St and Walden Ave & Thruway Transit Center. The journey, including transfers, takes approximately 7 h 3 min.

It takes approximately 6 h 50 min to get from Pittsburgh to Buffalo–Depew Station, including transfers.